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Neuroendocrine Perspectives Neuroendocrine Perspectives Volume 3 1st Edition - January 1, 1984
Editors: Eugenio E. Müller, Robert M. MacLeod
eBook ISBN: 9781483278131 9 7 8 - 1 - 4 8 3 2 - 7 8 1 3 - 1
Neuroendocrine Perspectives, Volume 3 provides information on amine and peptide biochemistry. This book discusses the availability of specific biochemical and histochemical… Read more
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Neuroendocrine Perspectives, Volume 3 provides information on amine and peptide biochemistry. This book discusses the availability of specific biochemical and histochemical techniques that have greatly advanced knowledge of central nervous system neurotransmitter and neuropeptide systems. Organized into nine chapters, this volume begins with an overview of the structure of corticotropin releasing hormone. This text then examines the possible role of the cerebrospinal fluid in the regulation of pituitary function. Other chapters consider the importance of cerebrospinal fluid as a route for the hypothalamic regulation of pituitary function. This book discusses as well the available information concerning the neuroendocrine mechanisms involved in the onset of female puberty in primate and subprimate species. The final chapter deals with pineal indole metabolism and its controlling mechanisms as well as information on the interactions of the pineal hormones with neuroendocrine-reproductive axis. This book is a valuable resource for pharmacologists, research workers, and students.
Contents Introduction Contributors Chapter 1 Topography of Chemically Identified Neurons in the Central Nervous System: Progress in 1981-1983 Introduction Amino Acids 1. GABA 2. Glycine 3. Glutamate 4. Aspartate 5. Taurine Acetylcholine Biogenic Amines 1. Dopamine 2. Norepinephrine 3. Epinephrine 4. Histamine 5. Serotonin 6. Minor Biogenic Amines Neuropeptides 1. Hypothalamic Neuropeptides 2. Brain-Borne Pituitary Peptides 3. Opioid Peptides 4. Brain-Borne Gastro-Intestinal Peptides 5. Other Neuropeptides Conclusions Chapter 2 Hypothalamic Organization of Corticotropin Releasing Factor (CRF) Producing Structures Introduction The Hypophysiotropic Neurons Location of Hypothalamic CRF-Producing Structures Early Studies Reevaluation The Role of The Hypothalamic Paraventricular Nucleus Is The Neural Lobe Involved in the Control of ACTH Secretion? What Is CRF? The 41-Residue CRF (CRF-41) 1. Effects in Vitroand in Vivo 2. Functional Studies 3. Hypothalamic Distribution of Ocrf-41i 4. Conclusions The Neurohypophyseal Peptides Vasopressinand Oxytocin 1. Effects in Vitroand in Vivo 2. Functional Studies 3. Hypothalamic Distribution of Vasopressinand Oxytocin 4. Conclusions Angiotensin II 1. Effects in Vitroand in Vivo 2. Functional Studies 3. Hypothalamic Distribution of Angiotensin II 4. Conclusions Epinephrineand Norepinephrine 1. Effects in Vitroand in Vivo 2. Functional Evidence 3. Hypothalamic Distribution of Epinephrineand Norepinephrine 4. Conclusions Other Substances With CRF Activity Perspectives of CRF Chapter 3 Neuropeptides in the Cerebrospinal Fluid Introduction Hypophysiotropic Function Mechanisms By Which Neural Peptides Might Reach The CSF 1. Trans-Median Eminence Transport 2. Circumventricular Organs 3. Diffusion From Nerve Cells 4. Transport Across The Blood-Brain Barrier Biologic Action 1. Hypophysiotropic Effects 2. Biologic Effects of Neural Peptides Other Than Pituitary Regulation 3. Evidence Favoring the Specificity For Biologic Responses of Neural Peptides Placed in the CSF Endogenous Neural Peptides in the CSF 1. TRH 2. LH-RH 3. Somatostatin 4. Opioid Peptides 5. Neurohypophyseal Peptides 6. Other 'Neural' Peptides 7. Adenohypophyseal Hormones 8. Sleep Factors Summaryand Conclusions Chapter 4 Neuropeptides in Shockand Traumatic Injury: Sitesand Mechanisms of Action Introduction Multiple Forms of Endogenous Opioidsand Their Localizations 1. Neuronal Localization 2. Hormonal Localization Regulation of Endogenous Opioid Release 1. Pituitary Gland 2. Adrenal Gland Multiple Opioid Receptors 1. Opioid Antagonists Endogenous Opioid Systems in the Pathophysiology of Shock 1. Endotoxic Shock 2. Hemorrhagic Shock 3. Spinal Shockand Trauma 4. Other Forms of Circulatory Shock Neuroendocrine-Endogenous Opioid Relationships in Experimental Shock 1. Sites of Action For Naloxone 2. Neuroendocrineand Autonomic Mechanisms That May Mediate Naloxone Responses 3. Which Endogenous Opioids Are Involved? 4. Multiple Opioid Receptors: Studies With Selective µand Δ Antagonists Thyrotropin Releasing Hormone As A Physiological Antagonist of Opioid Systems 1. TRH-Opioid Interactions 2. TRH in Shockand Spinal Trauma 3. TRHand Analogs: Sites of Action Conclusionsand Perspectives 1. Endogenous Opioids As Neuroendocrine Substances 2. Speculation On Endogenous Opioidsand TRH in Shockand Trauma 3. Which Is Better: Opioid Antagonists Or TRH? Chapter 5 Ectopic Hormone Production By Tumors: Growth Hormone-Releasing Factor Introductionand Historical Background Clinical Studies Suggesting Ectopic Production of GRF Biologic Characterization of Ectopic GH-Releasing Factor Isolationand Characterization of Ectopic GRF Clinical Effects of Synthetic GRF Radioimmunoassay of GRF Clinical Implications of Endogenous GRF Possible Role of Hypothalamic GRF in the Etiology of GH-Secreting Pituitary Tumors Chapter 6 The Onset of Female Puberty: Underlying Neuroendocrine Mechanisms Introduction The Initiation of Gonadotropin Release The Initiation of Ovarian Steroid Secretion The Neonatal-Infantile Period 1. The Infantile Hypothalamic-Pituitary Unit 2. The Infantile Ovary 3. Infantile Hypothalamic-Pituitary-Ovarian Interactions The Juvenile Period (Childhood) 1. The Juvenile Hypothalamusand Its Control of Pituitary Function 2. The Juvenile Ovary. Hormonaland Neurogenic Control 3. Juvenile Ovarian Regulation of Gonadotropin Release The Onset of Puberty 1. Gonadostat 'Resetting', Loss of A Central 'Restraint', Or Activation of Facilitory Mechanisms? 2. The Supportive Role of Pituitary Somatomammotropic Hormones 3. Metabolic Signals Influencing Puberty Onset The First Preovulatory Surge of Gonadotropins 1. Development of Estradiol Positive Feedback. The Central Component 2. The Ovary As A Trigger. Acquisition of Preovulatory Competence 3. The Cascade of Events Chapter 7 Prolactinand Ovarian Function Introduction Prolactinand The Normal Ovarian Cycle 1. Normal Follicular Growthand Development 2. Changes in Blood Concentrations of Prolactin 3. Changes in Ovarian Follicular Fluid Levels of Prolactin 4. Prolactin Receptors On The Ovary 5. Effect of Prolactin On Gonadotropin Receptors 6. Prolactinand Steroidogenesis in the Corpus Luteum 7. Prolactinand Steroidogenesis in the Follicle 8. Prolactinand Ovarian Interstitium 9. Prolactinand The Oocyte 10. Prolactin-Prostaglandin Interaction At The Ovary Prolactinand Puberty Lactationand Ovarian Activity 1. Suckling, Prolactinand The Suppression of Ovarian Activity 2. Pituitaryand Plasma Gonadotropinsand Response To LHRHand Estrogen 3. Role of Prolactin in Suppressing Gonadotropin Secretion 4. Changes Associated With The Resumption of Follicle Growthand Ovulation 5. Evidence For Direct Inhibition of Ovarian Function By Prolactin 6. Direct Effects of Prolactin On Gonadotropin Secretion Conclusions Chapter 8 Antimitotic Actions of Dopaminergic Drugs On Human Pituitary Tumors Introduction Effects On The Synthesisand Secretion of Prolactin Effects On Cell Division Data From Experimental Rat Pituitary Tumor Studies Studies in Man 1. Tumor Shrinkage? 2. Studies On The Pathology of Tumor Tissue 3. (Partial) Unresponsiveness To Dopamine Agonists Conclusions Chapter 9 Pineal Indoles: Producton, Secretionand Actions Introduction Pineal Indole Metabolism Control of Pineal Indole Metabolism 1. Extracellular Events 2. Intracellular Events Pineal Indoles in Bodily Fluids Reproductive Effects of Pineal Indoles 1. Melatonin 2. 5-Methoxytryptophol 3. 5-Methoxytryptamine Commentary Author Index Subject Index
Published: January 1, 1984
eBook ISBN: 9781483278131
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