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Studies in Natural Products Chemistry
1st Edition, Volume 45 - February 24, 2015
Editor: Atta-ur Rahman
Language: English
Hardback ISBN:9780444634733
9 7 8 - 0 - 4 4 4 - 6 3 4 7 3 - 3
eBook ISBN:9780081000519
9 7 8 - 0 - 0 8 - 1 0 0 0 5 1 - 9
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the mi…Read more
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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry.
The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Focuses on the chemistry of bioactive natural products
Contains contributions by leading authorities in the field
Presents sources of new pharmacophores
Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry
Preface
Chapter 1. Fabrication of Cellulose Hydrogels and Characterization of Their Biocompatible Films
Introduction
Fabrication of Cellulose Films and Their Properties
Cellulose Hydrogel Bioactivity
Concluding Remarks
List of Abbreviations
Chapter 2. Cannabis and Bioactive Cannabinoids
Cannabis
The Endocannabinoid System
Cannabinoids
The Therapeutic Potential of Cannabinoids
Concluding Remarks
List of Abbreviations
Chapter 3. Electrochemical Monitoring of the Pharmacological Activity of Natural Products
Introduction
General Aspects
Materials and Techniques
Correlation between Electrochemical Data and Activity
Final Considerations
List of Abbreviations
Chapter 4. Structural Elucidation of Saponins: A Combined Approach Based on High-Resolution Spectroscopic Techniques
Introduction
Saponin Classification
Saponin Structural Elucidation
Nuclear Magnetic Resonance Spectroscopy
Structural Elucidation of the Aglycone Portion
Structural Elucidation of the Sugar Portion
Glycosylation Site and Sugar Chain Branching
Further Structural Features
Advances in Structural Elucidation of Saponins Using MS
Tandem MS
NMR and MS at Work in Saponin Structural Elucidation
List of Abbreviations
Chapter 5. Ecdysteroids in Plants and their Pharmacological Effects in Vertebrates and Humans
Introduction
Chemical Structure of Phytoecdysteroids
Occurrence of Ecdysteroids in Plants
Biosynthesis and Metabolism of Phytoecdysteroids
Function of Ecdysteroids in Plants
Pharmacological Effects of Phytoecdysteroids
Concluding Remarks
List of Abbreviations
Chapter 6. Drimane-Related Merosesquiterpenoids, a Promising Library of Metabolites for Drug Development
Introduction
Occurrence, Classification, and Biosynthesis of Polyketide-MSRDs
Occurrence, Classification, and Biosynthesis of Shikimate-MSRDs
Occurrence, Classification, and Biosynthesis of Amino Acid-MSRDs
Biological Activities
Conclusions
Structural Abbreviations Used in the Chapter
Chapter 7. The Structure–Activity Relationships of Plant Secondary Metabolites with Antimicrobial, Free Radical Scavenging and Inhibitory Activity toward Selected Enzymes
Introduction
SARS for Compounds with Inhibitory Activity Against Selected Enzymes
Inhibitors of MMPS
Antibacterial and Antifungal Mechanism of Action of Selected Secondary Plant Metabolites
Structure–Free Radical Scavenging Activity Relationships for Selected Secondary Plant Metabolites
Antioxidant–Activity Relationship for Polyphenols
Antioxidant–Activity Relationship for Non-Phenolics
Mono- Di- and Sesquiterpenes
Carotenoids
Concluding Remarks
List of Abbreviations
Chapter 8. Marine Polyacetylenes: Distribution, Biological Properties, and Synthesis
Introduction
Marine Organisms as Source of Polyacetylenes
Synthesis of Polyacetylenes
Conclusion
List of Abbreviations
Chapter 9. Bioactive Natural Products from Marine-Derived Fungi: An Update
Alkaloids Isolated from Marine-Derived Fungi
Polypeptides Isolated from Marine-Derived Fungi
Polyketides and Polyketide Derivative Compounds Isolated from Marine-Derived Fungi
Lactones and Macrolides-Based Polyketides Isolated from Marine-Derived Fungi
Steroids Isolated from Marine-Derived Fungi
Terpenoids Isolated from Marine-Derived Fungi
Miscellaneous Metabolites Isolated from Marine-Derived Fungi
Chapter 10. Mushrooms: A Source of Exciting Bioactive Compounds
Introduction
Isolated Bioactive Compounds
Conclusion
List of Abbreviations
Chapter 11. Natural Bioactive Molecules: Mechanism of Actions and Perspectives in Organ Pathophysiology
Introduction
Role of Small Bioactive Molecules in Organ Pathophysiology
Beneficial Role of Macromolecules in Organ Pathophysiology
Conclusion
List of Abbreviations
Chapter 12. Oxindole Alkaloids of Uncaria (Rubiaceae, Subfamily Cinchonoideae): A Review on Its Structure, Properties, and Bioactivities
Background
Phytochemistry of Uncaria: Oxindole Alkaloids
Biogenesis of Oxindole Alkaloids in Uncaria
Biological and Pharmacological Studies on Oxindoles of Uncaria
Conclusion
Index
No. of pages: 554
Language: English
Edition: 1
Volume: 45
Published: February 24, 2015
Imprint: Elsevier
Hardback ISBN: 9780444634733
eBook ISBN: 9780081000519
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan
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