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Clinical Neuroendocrinology
1st Edition, Volume 124 - August 28, 2014
Editors: Eric Fliers, Marta Korbonits, J.A. Romijn
Language: English
Hardback ISBN:9780444596024
9 7 8 - 0 - 4 4 4 - 5 9 6 0 2 - 4
eBook ISBN:9780444626127
9 7 8 - 0 - 4 4 4 - 6 2 6 1 2 - 7
Clinical Neuroendocrinology, a volume in the Handbook of Clinical Neurology Series gives an overview of the current knowledge in the field of clinical neuroendocrin…Read more
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Clinical Neuroendocrinology, a volume in the Handbook of Clinical Neurology Series gives an overview of the current knowledge in the field of clinical neuroendocrinology. It focuses on the pathophysiology, diagnosis, and treatment of diseases of the hypothalamus and the pituitary gland. It integrates a large number of medical disciplines, including clinical endocrinology, pediatrics, neurosurgery, neuroradiology, clinical genetics, and radiotherapy. Psychological consequences of various disorders and therapies, as well as therapeutic controversies, are discussed. It is the first textbook in the field to address all these aspects by a range of international experts.
All contributors are recognized experts in the different fields of clinical neuroendocrinology
The book provides expanded coverage on hypothalamic mechanisms in human pathophysiology
The book includes current perspectives, diagnosis and treatment of pituitary diseases
Researchers, clinicians and advanced students in the fields of neuroendocrinology, neurology and clinical neuroscience
Handbook of Clinical Neurology 3rd Series
Foreword
Preface
Section 1: Clinical aspects of hypothalamic function
Development
Chapter 1: Genetic aspects of hypothalamic and pituitary gland development
Abstract
Introduction
Development of the hypothalamo-pituitary axis
Congenital hypopituitarism and associated defects
Overlap between congenital hypopituitarism and midline defects with kallmann syndrome
Conclusion and future directions
Chapter 2: Neuroendocrinology of pregnancy and parturition
Abstract
Introduction
The hypothalamus–pituitary–target gland axes during pregnancy
The placenta: a neuroendocrine organ
Stress-related hormones: implications in physiologic pregnancy and parturition and in obstetric complications
Chapter 24: Long-term effects of treatment of pituitary adenomas
Abstract
Treatment of pituitary adenomas: The historical perspective
Mortality
Hypopituitarism and mortality
Cardiovascular morbidity and pituitary disease
Failure to mimic physiologic hormone secretion with substitution
Hypothalamic dysfunction
Quality of life
Cognitive function and psychopathology
Acromegalic arthropathy as a model for disease-specific persistent morbidity
Implications for treatment and follow-up
Chapter 25: Neuroendocrine mechanisms in athletes
Abstract
Introduction
Neuroendocrine alterations in athletes
Impact on bone metabolism of athletic activity and associated neuroendocrine changes
Impact on neurocognitive function
Impact on fertility
Conclusion
Acknowledgments
Chapter 26: Uncertainties in endocrine substitution therapy for central hypocortisolism
Abstract
Introduction
Clinical assessment for hypocortisolism
Dynamic tests of hypocortisolism
Standard treatments for hypocortisolism
Conclusions
Chapter 27: Uncertainties in endocrine substitution therapy for central endocrine insufficiencies: hypothyroidism
Abstract
Introduction
Facts and uncertainties in central hypothyroidism diagnosis
Facts and uncertainties in central hypothyroidism replacement therapy
Novel perspectives for therapy of central hypothyroidism
Chapter 28: Uncertainties in endocrine substitution therapy for central endocrine insufficiencies: growth hormone deficiency
Abstract
Introduction
Patients with isolated growth hormone deficiency (e.g., caused by treatment with prophylactic cranial radiotherapy for lymphoblastic leukemia in childhood)
Patients with growth hormone deficiency and multiple hormone deficiencies caused by nonsecreting pituitary macroadenomas treated by surgery
Patients with growth hormone deficiency and multiple hormone deficiencies and with hypothalamic involvement caused by a craniopharyngioma
General uncertainties of growth hormone therapy
Conclusion
Chapter 29: Autoimmune hypophysitis: new developments
Abstract
Introduction
Pituitary autoantibodies
IGG4-Related hypophysitis
ANTI-PIT-1 Antibody syndrome
Autoimmunity and metabolic disease
Conclusion
Abbreviations
Index
No. of pages: 456
Language: English
Edition: 1
Volume: 124
Published: August 28, 2014
Imprint: Elsevier
Hardback ISBN: 9780444596024
eBook ISBN: 9780444626127
EF
Eric Fliers
Eric Fliers is Professor of Endocrinology at the University of Amsterdam, serving as head of the Department of Endocrinology and Metabolism at the Academic Medical Center in Amsterdam since 2007. He received a PhD in Neuroscience on the functional neuroanatomy of the human hypothalamus, followed by his MD (with honors), both from the University of Amsterdam. He was subsequently trained as an internist-endocrinologist. Fliers was one of the founders of the Netherlands Brain Bank. His current research interests include the hypothalamus-pituitary-thyroid axis, and the neuro-endocrine response to illness. Eric Fliers is the current chair of the Dutch Endocrine Society.
Affiliations and expertise
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
MK
Marta Korbonits
Prof. Márta Korbonits is a clinical academic endocrinologist with special interest in pituitary tumorigenesis and as well as metabolic effects of hormones. She graduated in medicine at Semmelweis Medical School in Budapest and works in the Department of Endocrinology at Barts and the London School of Medicine at St. Bartholomew’s Hospital in London since 1991, where currently she is Co-Centre Head. She received an MD and a PhD from the University of London and was a recipient of a Medical Research Council Clinician Scientist Fellowship to study ghrelin physiology and genetics. Her current interests include hormonal regulation of the metabolic enzyme AMP-activated protein kinase, the physiology and pathophysiology of ghrelin and endocannabinoids and pituitary tumours including familial cases. She has a large collection of familial isolated pituitary adenoma families and works on both the clinical characterization as well as molecular aspects of this disease.
She has published over 160 papers, numerous book chapters, and edited two books in the field of Endocrinology and has been an invited speaker on medical conferences all over the world. She serves on the editorial board of several prestigious endocrine journals and serves as referee for numerous high-impact journals and grant-giving bodies. She was heading the Program Organizing Committee of the Society for Endocrinology for three years, served on the Executive Committee of the Pituitary Society and ENEA and currently the European Society of Clinical Investigation and is an elected member of the Association of Physicians of Great Britain and Ireland. She has received numerous awards including the Nicholas Zervas Lectureship at Massachusetts General Hospital, Harvard Medical School and the prestigious Society for Endocrinology Medal.
She shares her time between clinical patient care, clinical research and laboratory based research as well as teaching at undergraduate and postgraduate level.
Affiliations and expertise
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, UK
JR
J.A. Romijn
Johannes A. (Hans) Romijn was trained in internal medicine in the Academic Medical Center, University of Amsterdam, followed by fellowships in intensive care and clinical endocrinology. He was professor and chairman of Medicine and of Endocrinology at the Leiden University Medical Center, The Netherlands between 1998 and 2010. Since 2010 he serves as professor and chairman of the Division and Department of Medicine, Academic Medical Center, University of Amsterdam in The Netherlands. He is currently the Editor-in-Chief of the European Journal of Endocrinology, the leading journal of the European Society of Endocrinology. His research focuses on the pathophysiology of endocrine and metabolic regulation, with a special focus on clinical neuroendocrinology.
Affiliations and expertise
Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands