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Recent Advances in Medicinal Chemistry, Volume 1
1st Edition - June 2, 2015
Editors: Atta-ur Rahman, Muhammad Iqbal Choudhary, George Perry
Language: English
Paperback ISBN:9780128039618
9 7 8 - 0 - 1 2 - 8 0 3 9 6 1 - 8
eBook ISBN:9780128039625
9 7 8 - 0 - 1 2 - 8 0 3 9 6 2 - 5
Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in…Read more
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Originally published by Bentham and now distributed by Elsevier,Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.
Edited and written by leading experts in medicinal chemistry research
Reviews recent advances in the field, including the characterization of inorganic nanomaterials as therapeutic vehicles
Covers a variety of topical areas, such as HPLC and in the analysis of tricyclic antidepressants in biological samples, and tannins and their influence on health
Medicinal Chemistry and Pharma researchers
Foreword
Preface
List of Contributors
Chapter 1: New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs
Abstract
1 Introduction
2 Principal Functions of NSAIDs and Aureolic Acid Anticancer Antibiotics and their Mechanism of Action
3 Other Functions of these Drugs and Mechanism of Actions
4 Chemical Dissection of the Drugs to Understand Alternate Functions
5 Conclusion
Acknowledgements
Conflict of Interest
Disclosure
Chapter 2: Updated Report on a Novel Mercaptopyruvate Sulfurtransferase Thioredoxin-Dependent Redox-Sensing Molecular Switch: A Mechanism for the Maintenance of Cellular Redox Equilibrium
Abstract
Introduction
A Redox-Sensing Molecular Switch Formed via an Intermolecular Disulfide Bond
Low Redox Potential Sulfenate Formation At A Catalytic Site Cysteine: Another Mechanism By Which Mst Serves As An Anti-Oxidant Protein
Conclusions
Acknowledgements
Conflict Of Interest
Disclosure
Chapter 3: Characterization of Inorganic Nanomaterials as Therapeutic Vehicles
Abstract
Introduction
Concluding Remarks
Acknowledgements
Conflict of Interest
Disclosure
Chapter 4: Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women
Abstract
Introduction
Conclusions
Acknowledgements
Conflict of Interest
Disclosure
Chapter 5: Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics
Abstract
Introduction
Bacterial Type II FAS the Biological Process
FabH as a Drug Target Differences and Advantages
Three Dimensional Structure of FabH
Substrate Binding and Specificity
Catalytic Mechanism and Substrate Binding
Molecular Modeling Studies of FabH
Concluding Remarks
Acknowledgements
Conflict of Interest
Disclosure
Chapter 6: Tannins and their Influence on Health
Abstract
1 Introduction
2 Classification of Tannins
3 Absorption and Metabolism of Tannins
4 Biological Activity
5 Human Intervention Studies
6 Adverse and Undesirable Effects
7 Conclusions
Acknowledgements
Conflict of Interest
Disclosure
Abbreviations
Chapter 7: Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors?
Abstract
Introduction
Role of RhoA in Normal and Tumor Cells
Statins Inhibit RhoA Activity
Statins and Tumor Growth/Apoptosis
Statins and Angiogenesis
Statins and Metastasis
Statins, Chemotherapy Efficacy and Multidrug Resistance
Statins and Chemoprevention of Tumors
Statins in Cancer Treatment
Acknowledgements
Conflict of Interest
Disclosure
Chapter 8: Carotenoids that are Involved in Prostate Cancer Risk
Abstract
Introduction
Types of Carotenoids and their Distribution in Diets
Conclusions
Acknowledgements
Conflict of Interest
Disclosure
Chapter 9: Preclinical Studies of Saponins for Tumor Therapy
Abstract
Diverse Structures and Functions of Saponins
Saponins as Anti-Cancer Agents
Dioscins
Saikosaponins
Julibrosides
Soy Saponins
Ginseng Saponins
Avicins
Knowledge, Gaps and Future
Combinations of Saponins and Other Anti-Cancer Agents
Conclusions
Acknowledgements
Conflict of Interest
Disclosure
Abbreviations
Chapter 10: Pharmacological Neuroprotection for Acute Spinal Cord Injury
Abstract
1 Introduction
2 Epidemiology
3 Pathophysiology
4 Search Criteria
5 Current Treatment of Acute Spinal Cord Injuries
6 Promising Future Pharmacological Therapies
Conclusions
Acknowledgements
Conflict of Interest
Disclosure
Chapter 11: HPLC and its Essential Role in the Analysis of Tricyclic Antidepressants in Biological Samples
Abstract
1 Introduction
2 Chemistry and Activity
3 Analytical Methods
4 Conclusions
Acknowledgements
Conflict of Interest
Disclosure
Abbreviations
Chapter 12: Gene Expression Profiles in Breast Cancer to Identify Estrogen Receptor Target Genes
Abstract
Introduction
Estrogen Receptors
Mechanisms of ER Action
Global Gene Expression Profiling of ER Action
Future Considerations
Acknowledgements
Conflict of Interest
Disclosure
Chapter 13: Trans-Plasma Membrane Electron Transport in Human Blood Platelets: An Update
Abstract
Plasma Membrane Redox System
Medicinal Effects on Platelet PMR System
Acknowledgements
Conflict of Interest
Abbreviations
Chapter 14: Role of Intermediate States in Protein Folding and Misfolding
Abstract
Introduction
Acknowledgements
Conflict of Interest
Disclosure
Index
No. of pages: 486
Language: English
Edition: 1
Published: June 2, 2015
Imprint: Bentham Science Publishers
Paperback ISBN: 9780128039618
eBook ISBN: 9780128039625
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan
MC
Muhammad Iqbal Choudhary
Muhammad Choudhary, PhD, is a Professor of the International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan. He is a member of the Royal Society of Chemistry, London; American Chemical Society; International Union of Pure and Applied Chemistry (IUPAC); American Society of Pharmacology; New York Academy of Sciences; Federation of Asian Chemical Societies (FACS); and he serves on the executive board of the Asian Network of Research on Anti Diabetic Plants (ANRAP). He is a recipient of the National Book Foundation's Prize for Chemistry and the Economic Cooperation Organization (ECO) Award in Education, 2006, given by the President of Azerbaijan. He has published 24 books, more than 570 papers, and 20 patents.
Affiliations and expertise
Professor, International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Karachi, Pakistan
GP
George Perry
Dr. George Perry, Ph.D. Professor of Biology and Chemistry
Semmes Foundation Distinguished University Chair in Neurobiology
He is a neuroscientist known for his work on neuronal oxidation of nucleic acids in Alzheimer's disease. He is distinguished as one of the top Alzheimer’s disease researchers with over 1000 publications, won numerous awards, and is one of the top 100 most-cited scientists.
Affiliations and expertise
Department of Biology, The University of Texas at San Antonio, University of Texas, San Antonio, TX, USA
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