»
Cell Press Reviews: Core Concepts in Cell Biology
 
 

Cell Press Reviews: Core Concepts in Cell Biology, 1st Edition

 
Cell Press Reviews: Core Concepts in Cell Biology, 1st Edition,ISBN9780124201934
 
 
 

AP Cell

9780124201934

9780127999180

484

235 X 191

Collates topical review articles recently published in Cell Press journals to offer a broad overview of the recent research developments in cell biology

Print Book + eBook

USD 35.94
USD 59.90

Buy both together and save 40%

Print Book

Paperback

In Stock

Estimated Delivery Time
USD 34.95

eBook
eBook Overview

DRM-free included formats : EPUB, Mobi (for Kindle), PDF

USD 24.95
Add to Cart
 
 

Key Features

  • Provides timely, comprehensive coverage across a broad range of cell biological topics
  • Offers foundational knowledge and expert insights to students and others new to the field
  • Features reviews from leaders in cell biology research and discussion of future directions for the field
  • Includes articles originally published in Cell, Current Biology, Developmental Cell, and Trends in Cell Biology

Description

Written by leading cell biologists and curated by Cell Press editors, reviews in the Cell Press Reviews: Core Concepts in Cell Biology publication informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field including:

  • Signaling mechanisms and membrane biology
  • Cytoskeletal self-organization and cell polarity
  • Organelle dynamics and biogenesis
  • Morphogenesis and cell motility
  • Chromatin and genome organization in nuclear function

Contributions come from leading voices in cell biology, who are defining the future of their field, including:
- Tom Misteli, National Cancer Institute
- Galit Lahav, Harvard Medical School
- Scott D. Emr, Cornell University
- David G. Drubin, University of California, Berkeley
- Tom Rapoport, Harvard Medical School
- Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden

This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals.

Readership

Academic, medical researchers and students across cell biology, molecular biology, developmental biology, stem cells

Cell Press Reviews: Core Concepts in Cell Biology, 1st Edition

About Cell Press

Contributors

Preface

Chapter 1. The Cell Biology of Genomes: Bringing the Double Helix to Life

Acknowledgments

Summary

Introduction

The Stochastic Genome

Epigenetics—and When Epigenetics is not Epigenetics

Genome Organization as a Modulator of Genome Function

Facing the Complexity

References

Chapter 2. Condensin, Chromatin Crossbarring and Chromosome Condensation

Acknowledgements

Summary

Introduction

Molecular Architecture of Condensin

Differential Contributions of Condensin I and II to Chromosome Structure

Cell-Cycle Regulation of Chromosome Condensation

Towards a Mechanistic Understanding of Chromosome Condensation

A Model for Mitotic Chromosome Condensation

References

Chapter 3. Nuclear Positioning

Acknowledgments

Summary

Introduction

The Nuclear Positioning Toolbox

Initiation of Nuclear Movement

Characteristics of Nuclear Movements

MT-Mediated Nuclear Movement

Actin-Mediated Nuclear Movement

Nuclear Positioning and Disease

Cellular Significance of Nuclear Positioning: Hypotheses and Perspectives

Conclusions

References

Chapter 4. Evolution and Function of the Mitotic Checkpoint

Acknowledgments

Summary

Mitosis, Kinetochores, and the Mitotic Checkpoint

Evolution of the MC and its Auxiliary Proteins

The Inhibitor and its Target: MCC and Cdc20

Evolution, Function, and Regulation of Cdc20

Feedback Control of the MC: Ubiquitination of Cdc20 by the APC/C

Catalyzing MCC Production

The APC/C Pseudosubstrate Inhibitor within the MCC

The Fate of a Paralog: Evolution and Function of Bub1

Kinetochore Scaffolds for the Mitotic Checkpoint

Regulating the MCC: Essential and Conserved Contributions of Mitotic Kinases

Auxiliary MC Proteins: The RZZ Complex

Releasing the Brake: MC Silencing

Concluding Thoughts and Future Directions

Supplemental Information

References

Chapter 5. Cell Division Orientation in Animals

Summary

Introduction

Shaping Tissues and Organs

Generating Cellular Diversity

Switching the Division Axis to Generate Cellular Diversity

Mechanism of Cell Division Orientation: Extracellular Cues

Mechanism of Cell Division Orientation: Intrinsic Cues

Connecting Extrinsic and Intrinsic Polarity Cues to Control Oriented Cell Division

PCP Control of Cell Shape and Cell Division Orientation

NuMA- and PCP-Independent Spindle Orientation Pathways

Developmental Consequences of Altered Cell Division Orientation

Conclusion

References

Chapter 6. Cell Polarity: Mechanochemical Patterning

Acknowledgments

Summary

Ubiquity and Universality During Cell Polarization

Symmetry Breaking and Pattern Formation in Chemical Systems

Mechanically Polarizing Systems

Coupled Mechanochemical Systems

Concluding Remarks

References

Chapter 7. Encoding and Decoding Cellular Information through Signaling Dynamics

Acknowledgments

Summary

Introduction

Quantifying Dynamics in Living Systems

Impact of Identity and Strength of Upstream Stimuli

Dynamics Associated with Specific Downstream Responses

Targeted Perturbations of Signaling Dynamics

Linking Dynamics with Network Structure

Functions Achieved through Modulation of Signaling Dynamics

Conclusions and Future Directions

References

Chapter 8. Directed Cytoskeleton Self-Organization

Acknowledgments

Summary

Setting Boundaries

Actin Network Self-Organization

MT Network Self-Organization

Cellular Self-Organization

Tissue self-organization

Concluding Remarks

References

Chapter 9. Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

Acknowledgments

Summary

Introduction

Bcl-2 Family Members

Mechanisms of Activation of Proapoptotic Bcl-2 Family Members

How Does Bax or Bak Permeabilize the Outer Mitochondrial Membrane?

Mechanistic Link between Mitochondrial Dynamics and MOMP: The Role of Membrane Hemifusion/Hemifission Intermediates

The Role of Mitochondria in Drosophila Cell Apoptosis

Apoptosis in the Worm

Bcl-2 Family Proteins and Mitochondrial Dynamics

Concluding Remarks

References

Chapter 10. Golgi Membrane Dynamics and Lipid Metabolism

Acknowledgements

Summary

Introduction

Ptdins-4-Phosphate and TGN Function

The Yin and Yang of Lipid Transfer Proteins and TGN Functions

Metazoan Lipid Transfer Proteins and the Golgi System

Sac1 Phosphoinositide Phosphatases and the Golgi System

Diacylglycerol and the Transport Carrier Cycle

Phosphatidic Acid Metabolism and Golgi Membrane Trafficking

PtdOH Remodeling Enzymes and Golgi Dynamics

Genetic Models for PLD Function

Genetic Models for BARS Function

Amino-Phospholipids and Membrane Trafficking

Sterols and the Golgi Complex

Glycolipid Transfer Proteins

Concluding Thoughts

References

Chapter 11. Weaving the Web of ER Tubules

Acknowledgments

Summary

Introduction

The Cytoskeleton

Curvature-Stabilizing Proteins

Atlastin GTPase-Mediated Homotypic ER Fusion

Mechanism of ATL-Mediated Fusion

Homotypic ER Fusion in Yeast and Plants

Perspective

References

Chapter 12. The ESCRT Pathway

Acknowledgments

Summary

Introduction

The ESCRT Complexes

Cargo: ESCRT-Mediated Cargo Recognition and Sorting

ESCRT-Mediated Membrane Deformation and Scission

Closing

References

Chapter 13. Mechanisms of Autophagosome Biogenesis

Acknowledgements

Summary

Introduction

Autophagosome Formation

Membrane Sources for Phagophores

Transition from Autophagosome Precursor to Phagophore

Transition from Phagophore to Autophagosomes — Roles of Atg8 Proteins

Synthesis, Challenges and Future Questions

References

Chapter 14. Organelle Growth Control through Limiting Pools of Cytoplasmic Components

Acknowledgements

Summary

Introduction

How Can the Cytoplasm Provide Dynamic Size Control?

Control of Centrosome Size

Centriole Duplication

Nuclear Size Control — Limiting Component or Active Control?

Cell Polarity — Global Control of Size and Number

Flagellar Length Control — Competition for Limiting Components

Concluding Remarks

References

Chapter 15. Curvature, Lipid Packing, and Electrostatics of Membrane Organelles: Defining Cellular Territories in Determining Specificity

Acknowledgments

Summary

Introduction

Biochemistry on Lipid Membrane Surfaces

Recognition of Organelles by Peripheral Proteins

Membrane Electrostatics

Lipid-Packing Defects

Membrane Curvature

Changing Membrane Properties

Phagocytosis: Decrease in Electrostatics Drives Membrane Maturation

Feedback Loops Linking Membrane Curvature and Vesicle Biogenesis

Barkor: Interplay between Curvature and PI(3)P Synthesis for Autophagosome Formation

Lipid-Packing Defects as an Index of Lipid Droplet Expansion

Membrane Contact Sites: When Lipid Territories Meet

Dangerous Combinations

Limits of the Two Territories Model and Perspectives

References

Chapter 16. Clathrin-Mediated Endocytosis in Budding Yeast

Acknowledgements

Summary

Endocytosis in Yeast: Past, Present and Future

Early Stages of Endocytosis, Including Cargo Selection

Coat Maturation

WASP/Myosin Recruitment

Actin Polymerization

Scission and Uncoating

Phosphorylation, Ubiquitination and Lipid Modification

Ultrastructural Analysis

Theoretical Modeling

Relationship to Mammalian Endocytosis

Concluding Remarks

References

Glossary

Chapter 17. Life at the Leading Edge

Acknowledgments

Summary

Introduction

Lamellipodia

Filopodia

Invadopodia

Blebs

Collective Cell Migration

Conclusions and Perspectives

References

Chapter 18. Use the Force: Membrane Tension as an Organizer of Cell Shape and Motility

Acknowledgments

Summary

Introduction

Feedback between PM Tension and Cellular Processes

Role of Cytoskeletal Tension Versus PM Tension

Sensing PM Tension

Global Versus Local Membrane Tension

Future Directions

References

Chapter 19. Thinking Outside the Cell: How Cadherins Drive Adhesion

Acknowledgments

Summary

The Classical Cadherin Family

Extracellular Cadherin Domains Drive Adhesion from Outside the Cell

Mechanism of Adhesive Binding Between Single Cadherin Molecules from Apposed Cells

Speed Dating: The X-dimer Intermediate

From Bonds to Junctions

Non-Classical Cadherin Subfamilies Suggest Diversity of Adhesive Mechanism

Concluding Remarks

References

Chapter 20. Actin Cortex Mechanics and Cellular Morphogenesis

Acknowledgments

Summary

The Actomyosin Cortex Controls Animal Cell Shape

Structure and Composition of the Cortical Network

Mechanical Properties of the Cortex

Physical Descriptions of the Cortex

Cortex Contractility and Cell Shape Control

Dysregulation in Disease

Concluding Remarks

References

Glossary

Index

Quotes and reviews

"…collates topical review articles recently published in Cell Press journals…informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field…" --Anticancer Research 34, 2014

 
 
Free Shipping
Shop with Confidence

Free Shipping around the world
▪ Broad range of products
▪ 30 days return policy
FAQ

Contact Us