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Craniofacial Development
1st Edition, Volume 115 - November 16, 2015
Editor: Yang Chai
Language: English
Hardback ISBN:9780124081413
9 7 8 - 0 - 1 2 - 4 0 8 1 4 1 - 3
eBook ISBN:9780124166110
9 7 8 - 0 - 1 2 - 4 1 6 6 1 1 - 0
Craniofacial Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in th…Read more
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, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field.
This volume covers research methods in Craniofacial Development, and includes sections on such topics as microRNAs in craniofacial development and epigenetic regulation in craniofacial development.
Provides a comprehensive book on craniofacial development and tissue regeneration
Authored by leading experts in this field
Carefully organized to cover an array of topics critical in helping readers learn the most important aspects of craniofacial development and tissue regeneration
People who work on craniofacial development and tissue regeneration (researchers, instructors, and clinicians).
Preface
Introduction to Craniofacial Development
Acknowledgments
Part 1: Craniofacial Morphogenesis and Regeneration: From Cells to Tissues to Organs
Chapter One: Craniofacial Muscle Development
Abstract
1 Head Muscle Formation and Heterogeneity: Extraocular Muscles, Pharyngeal Mesoderm, and Neck Muscles
2 Overlap Between Cardiac and Pharyngeal Muscle Progenitors
3 FGF–ERK Signaling During Myogenesis
4 Head Muscle Regeneration
Chapter Two: Mandible and Tongue Development
Abstract
1 Early Development of the Mandibular Arch
2 Mandibular Bone Development
3 Tongue Development
4 Evolution of the Mandible and Tongue
5 Mechanical Relationship Between the Mandible and Tongue
6 Stem Cells in Mandible and Tongue Regeneration
7 Conclusion
Chapter Three: Cellular and Molecular Mechanisms of Palatogenesis
Abstract
1 Introduction
2 Regulation of Palatal Shelf Growth and Patterning
3 Proper Periderm Differentiation Is Critical for Normal Palatogenesis
4 Palatal Fusion: Formation and Dissolution of the Intershelf Epithelial Seam by Cell Convergence and Extrusion
5 Concluding Remarks
Acknowledgments
Chapter Four: Genetic Influences on Temporomandibular Joint Development and Growth
Abstract
1 Introduction
2 Normal Morphogenesis and Cell Biology of the TMJ
3 Genes That Affect Mandibular Condylar Cartilage
4 Genes Affecting the Mandibular Fossa
5 Genes Affecting the Articular Disc and Joint Cavitation
Chapter Eight: Stem Cells in Tooth Development, Growth, Repair, and Regeneration
Abstract
1 Stem Cells in Tooth Development
2 Stem Cells in Dentin Repair: Tertiary Dentinogenesis
3 The Continuously Growing Incisor
Acknowledgments
Chapter Nine: Development and Integration of the Ear
Abstract
1 Function and Anatomy of the Mammalian Ear
2 Development of the Pharyngeal Apparatus
3 Development of the Middle Ear
4 Development of the External Ear
5 Development of the Inner Ear
6 Mechanism and Defects of Integration During Development
7 Conclusion
Part 2: Craniofacial Patterning and Signaling Mechanisms
Chapter Ten: Zebrafish Craniofacial Development: A Window into Early Patterning
Abstract
1 Zebrafish Craniofacial Anatomy
2 Imaging Craniofacial Development
3 Genetic Analyses of Craniofacial Development
4 Future Directions
5 Conclusions
Chapter Eleven: Regulation of Jaw Length During Development, Disease, and Evolution
Abstract
1 Introduction: On Being the Right Jaw Size During Development and Evolution
2 Part 1: Early Determinants of Jaw Length
3 Part 2: Determinates of Jaw Length During Skeletal Differentiation
4 Part 3: Determinates of Jaw Length During Late-Stage Growth
Chapter Twelve: Facial Morphogenesis: Physical and Molecular Interactions Between the Brain and the Face
Abstract
1 Introduction
2 Relationship Between the Brain and the Face
3 Implications for Structural Diseases of the Face
4 The Role of Brain–Face Interactions in Generating Evolutionary Variation
5 Conclusions
Chapter Thirteen: Developmental Plasticity of Patterned and Regenerating Oral Organs
Abstract
1 Introduction and Background
2 The Continuum of Oral Organ Patterning and Regeneration
3 The Plasticity of Stem-Based Organ Regeneration
4 Cichlids Combine the Features of Renewing and Replacing Oral Organ Systems
Acknowledgments
Chapter Fourteen: Regulating Craniofacial Development at the 3′ End: MicroRNAs and Their Function in Facial Morphogenesis
Abstract
1 Introduction
2 Craniofacial Development: Cell Types and Tissue Interactions
3 miRNA Biogenesis, Structure, and Function
4 miR-140: The First Individual miRNA Associated with Facial Morphogenesis
5 miRNA Function in Craniofacial Development—Lessons from Deletion of Dicer1
6 The miR-17~ 92 Family: Complex and Compensating Actions During Vertebrate Development
7 miRNA Regulation of Bone and Cartilage Development
8 miRNAs and Odontogenesis
9 miRNAs and Salivary Gland Development
10 miRNAs: A Potential Tool for Correcting Craniofacial Defects
11 Summary
Chapter Fifteen: Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation
Abstract
1 Introduction
2 Signaling Pathways Regulating Craniofacial Development
3 Families of Transcription Factors
4 Questions for the Future
Part 3: Disease Models, Human Genetics, Genomics and Dynamic Imaging
Chapter Sixteen: Mouse Models of Rare Craniofacial Disorders
Abstract
1 Introduction
2 Ribosomopathies
3 Ciliopathies
4 Syngnathia
5 Conclusions and Perspectives
Acknowledgments
Chapter Seventeen: From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models
Abstract
1 Models to Uncover Genetics of Cleft Lip and Palate
2 Treacher Collins: Proof of Concept of a Nonsurgical Therapeutic for a Craniofacial Syndrome
3 RASopathies: Understanding and Developing Treatment for Syndromes of the RAS Pathway
4 Craniosynostosis: Pursuing Genetic and Pharmaceutical Alternatives to Surgical Treatment
5 XLHED: Developing Treatment Based on Knowledge Gained from Mouse and Canine Models
6 Concluding Thoughts
Acknowledgments
Chapter Eighteen: Signaling Pathways in Craniofacial Development: Insights from Rare Skeletal Disorders
Abstract
1 Rare Skeletal Disorders and Their Classification
2 Building the Skeleton
3 Signaling Pathways in Skeletal Development and Their Associated Skeletal Disorders
4 Hedgehog
5 Parathyroid Hormone-Related Protein
6 WNT
7 NOTCH
8 Transforming Growth Factor Beta Superfamily
9 Fibroblast Growth Factor
10 Future Directions
Acknowledgments
Chapter Nineteen: Clinical and Genomic Approaches for the Diagnosis of Craniofacial Disorders
Abstract
1 Introduction
2 Clinical Evaluation and Dysmorphology
3 Chromosomal Aberrations
4 Evolution of Copy Number Detection
5 Single-Candidate Gene and Panel-Based Testing
6 Next-Generation Sequencing
7 Whole-Exome Sequencing and Whole-Genome Sequencing
8 Future Perspectives
Chapter Twenty: Morphometrics, 3D Imaging, and Craniofacial Development
Abstract
1 Introduction
2 Morphometrics and Morphospaces
3 Approaches to Morphometrics
4 Landmarks and Homology
5 Quantifying Variation
6 3D Imaging for Morphometrics
7 Future Directions—Integrating Molecular and Anatomical Imaging
Acknowledgments
Chapter Twenty-one: Imaging the Cell and Molecular Dynamics of Craniofacial Development: Challenges and New Opportunities in Imaging Developmental Tissue Patterning
Abstract
1 Introduction
2 Challenge of Temporal and Spatial Scales in Imaging of Craniofacial Development
3 Perspective
No. of pages: 668
Language: English
Edition: 1
Volume: 115
Published: November 16, 2015
Imprint: Academic Press
Hardback ISBN: 9780124081413
eBook ISBN: 9780124166110
YC
Yang Chai
Dr. Yang Chai is the George and MaryLou Boone Professor at the University of Southern California. He serves as the Director of the Center for Craniofacial Molecular Biology (CCMB) and Associate Dean of Research at the Ostrow School of Dentistry University of Southern California. He is most noted for his research on the molecular regulation of cranial neural crest cells during craniofacial development and malformations. Over the years, his laboratory has developed multiple genetically engineered mouse models in order to investigate how craniofacial organs, such as tooth, palate, mandible, maxilla, tongue and calvaria are formed and how tissue-tissue interactions control patterning and morphogenesis. He is also interested in stem cells and craniofacial tissue regeneration. More recently, his laboratory has significantly expanded their effort in linking animal models with human birth defects and has successfully rescued craniofacial malformations by manipulating signaling pathways during embryogenesis.
Dr. Chai has authored more than 120 scientific papers and numerous book chapters. His work has earned him multiple awards including the 2011 IADR (International Association of Dental Research) Distinguished Scientist Award. He is an elected member of the American Academy of Arts and Sciences (AAAS). He serves on the editorial board of Developmental Biology and Journal of Bone and Mineral Research. He also serves on the Board of Scientific Counselors at the National Institute of Dental and Craniofacial Research, National Institute of Health. He also serves on NIH study sections and reviews grant applications for the Welcome Trust and other international research organizations. Dr. Chai earned a DMD degree from Peking University School of Stomatology as well as DDS and PhD in Craniofacial Biology from the University of Southern California.
Affiliations and expertise
University of Southern California, Los Angeles, CA, USA