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Apoptosis and Development
1st Edition, Volume 114 - October 5, 2015
Editor: Hermann Steller
Language: English
Hardback ISBN:9780124104259
9 7 8 - 0 - 1 2 - 4 1 0 4 2 5 - 9
eBook ISBN:9780124095984
9 7 8 - 0 - 1 2 - 4 0 9 5 9 8 - 4
Apoptosis and Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in th…Read more
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, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field.
This volume covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ line cell death in Drosophila.
Continues the legacy of this premier serial with quality chapters authored by leaders in the field
Includes descriptions of the most recent advances in the field
Covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ line cell death in Drosophila
Graduate students in developmental and cell biology; established nonexpert scientists in these fields who aim to get both a conceptual overview of new developments in the area and an up-to-date review of the literature.
Preface
Chapter One: Cell Death in C. elegans Development
Abstract
1 Introduction
2 Core Apoptosis Regulators in C. elegans
3 The Core Apoptotic Pathway of C. elegans
4 Regulating Apoptosis
5 The Engulfment Genes and Their Roles in Cell Death
6 Linker Cell Death
7 Looking Ahead
Acknowledgments
Chapter Two: Mitochondrial Cell Death Pathways in Caenorhabiditis elegans
Abstract
1 Introduction
2 Mitochondria: A Central Player in Mammalian Apoptosis
3 Programmed Cell Death in C. elegans
4 Mitochondrion Is an Important Component in C. elegans Programmed Cell Death
5 Concluding Remarks
Acknowledgments
Chapter Three: Autophagy in Cell Life and Cell Death
Abstract
1 Introduction
2 Autophagy Genes
3 Autophagy and Cell Survival
4 Autophagy and Cell Death
5 Conclusions
Acknowledgments
Chapter Four: The End of the Beginning: Cell Death in the Germline
Abstract
1 Overview of Cell Death Pathways
2 Death of Primordial Germ Cells
3 Germline Cell Death in the Adult Ovary
4 Cell Death in the Testis
5 Comparison of PCD in the Drosophila and Mammalian Ovary
6 Conclusion
Acknowledgements
Chapter Five: The HOX–Apoptosis Regulatory Interplay in Development and Disease
Abstract
1 Introduction
2 Hox Genes: Homeotic Genes with Master Regulatory Functions
3 Apoptosis: The Controlled Killing of Cells
4 Hox–Apoptosis Regulatory Interactions During Development
5 Interplay of Hox Genes and Apoptosis in the Disease Context
6 Concluding Remarks
Acknowledgments
Chapter Six: Programmed Cell Death and Caspase Functions During Neural Development
Abstract
1 Introduction
2 Neurotrophic Support for Neuronal or Glial Survival
3 Involvement in Morphogenesis
4 Elimination of Morphogen-Producing Cells
5 Intrinsic Regulation of the Number of Progeny from a Specific Cell Lineage
6 Canceling Developmental Errors
7 Neural Cell Death in Sensory System Development: The Visual System as a Model
8 The Role of Neural Cell Death in Tissue Remodeling
9 Glial Function in Controlling Neural Architecture by Elimination of Dead Cells
10 The Nonapoptotic Functions of Caspases in Neural Development
11 Neurite Pruning
12 Mechanisms that Control Nonapoptotic Caspase Activation
13 Transient or Weak Caspase Activation
14 Local Caspase Activation
15 Conclusion
Acknowledgments
Chapter Seven: Regulation of Cell Death by IAPs and Their Antagonists
Abstract
1 Introduction
2 IAP/Antagonist Interaction
3 Mitochondrial Association of IAP-Antagonists
4 The Role of Mammalian IAP-Antagonists
5 Transcriptional Regulation of Drosophila IAP-Antagonists
6 Posttranscriptional Regulation of IAP-Antagonists
7 The Role of IAP-Antagonists in Nervous System Development
8 IAPs and Their Antagonists in Sculpting Morphogenesis
9 Nonapoptotic Roles of IAPs in Morphogenesis, Cell Migration, and Proliferation
10 The Roles of IAPs in the Innate Immune Response
11 Concluding Remarks
Acknowledgments
Chapter Eight: Ubiquitin-Mediated Regulation of Cell Death, Inflammation, and Defense of Homeostasis
Abstract
1 Introduction
2 Ubiquitin as Mediator of Signaling Events
3 Ub as Arbiter of Life and Death—TNF Signaling as Paradigm
4 Ub-Dependent Regulation of RIPK1 and the Ripoptosome
5 IAP-Mediated Regulation of Caspases
6 Concluding Remarks
Acknowledgments
Chapter Nine: The Sound of Silence: Signaling by Apoptotic Cells
Abstract
1 Apoptosis: A Silent Death?
2 Apoptotic Signals Dictate Immunological Responses to Cell Death
3 Apoptotic Cells Directly Influence Tissue Homeostasis and Growth Control
4 Apoptosis: A Loud Death
Acknowledgments
Chapter Ten: Clearance of Apoptotic Cells and Pyrenocytes
Abstract
1 Introduction
2 Apoptosis and Signal Transduction
3 The Engulfment of Apoptotic Cells
4 The Engulfment of Pyrenocytes
5 DNA Degradation in Macrophages
6 Perspectives
Chapter Eleven: Apoptotic Cell Clearance in Development
Abstract
1 Introduction
2 Professional and Nonprofessional Phagocytes During Development
3 How Do Phagocytes “Sense” Apoptotic Cells?
4 How Do Phagocytes Recognize Apoptotic Cells?
5 Intracellular Phagocytic Machinery
6 How Do Phagocytes Become Phagocytic?
7 Why Are Living Cells Not Removed by Phagocytes?
8 Glial Phagocytosis of Apoptotic Neurons in the Developing CNS
9 Additional Examples of Apoptotic Cell Clearance During Development
10 Stress-Induced Upregulation of Phagocytosis During Development
11 Anti-Inflammatory Response Following Apoptotic Cell Clearance
12 Phagocytosis-Promoted PCD
13 Concluding Remarks
Acknowledgments
Chapter Twelve: The Morphogenetic Role of Apoptosis
Abstract
1 Introduction
2 Part I: Cytoskeletal Control of Apoptotic Cell Dynamics
3 Part II: Influence of Apoptotic Cells on Their Surroundings
4 Conclusion
Index
No. of pages: 388
Language: English
Edition: 1
Volume: 114
Published: October 5, 2015
Imprint: Academic Press
Hardback ISBN: 9780124104259
eBook ISBN: 9780124095984
HS
Hermann Steller
Howard Hughes Medical Institute, Strang Laboratory of Apoptosis and Cancer Biology, The Rockefeller University, USA
Affiliations and expertise
Howard Hughes Medical Institute, Strang Laboratory of Apoptosis and Cancer Biology, The Rockefeller University, USA