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Regenerative Biology and Medicine
1st Edition - August 28, 2006
Author: David L. Stocum
Language: English
eBook ISBN:9780080493022
9 7 8 - 0 - 0 8 - 0 4 9 3 0 2 - 2
The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and…Read more
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The purpose of the book is to bring together in one place the different facets of regenerative biology and medicine while providing the reader with an overview of the basic and clinically-oriented research that is being done. Not only does the content cover a plethora tissues and systems, it also includes information about the developmental plasticity of adult stem cells and the regeneration of appendages.As part of its balanced presentation, Regenerative Biology and Medicine does address the biological/bioethical issues and challanges involved in the new and exciting field of regenerative biology and medicine.
*Tissues covered include skin, hair, teeth, cornea, and central neural types *Systems presented are digestive, respiratory, urogenital, musculoskeletal, and cardiovascular *Includes amphibians as powerful research models *Discusses appendage regeneration in amphibians and mammals
Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators
Chapter 1: An Overview of Regenerative Biology and Medicine
Introduction
A Brief History of Regenerative Biology and Medicine
The Biology of Regeneration
1. Regeneration Takes Place at all Levels of Biological Organization
2. Mechanisms of Regeneration at the Tissue Level
3. Epimorphosis and Morphallaxis
4. Evolutionary Significance of Regeneration and Fibrosis
Strategies of Regenerative Medicine
1. Cell Transplantation
2. Bioartificial Tissues
3. Induction of Regeneration In Situ
Summary
References
Chapter 2: Repair of Skin Wounds by Fibrosis
Introduction
Structure of Adult Mammalian Skin
The Effect of Wound Type and Extent on Dermal Repair
Phases of Repair in Excisional Wounds
1. Hemostasis and Clot Formation
2. Inflammation
3. Structural Repair
4. The Role of Wound Contraction in Dermal Repair
Molecular Comparison of Wounded vs. Unwounded Skin
Fetal Skin Heals Without Scarring
1. Cellular and ECM Differences Between Fetal and Adult Wound Healing
2. Fetal Wounds have a Minimal Inflammatory Response
Summary
References
Chapter 3: Regeneration of Epidermal Tissues
Introduction
Regeneration of Epidermis and Hair
1. Maintenance Regeneration
2. Injury-Induced Regeneration of the IFE
Regeneration of Nails
Regeneration of Dental Tissues
Regeneration of the Lens
1. Structure of the Eye and Lens
2. Cellular Events of Lens Regeneration in the Newt Eye