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Advances in Polyurethane Biomaterials
1st Edition - January 23, 2016
Editors: Stuart L. Cooper, Jianjun Guan
Language: English
Hardback ISBN:9780081006146
9 7 8 - 0 - 0 8 - 1 0 0 6 1 4 - 6
eBook ISBN:9780081006221
9 7 8 - 0 - 0 8 - 1 0 0 6 2 2 - 1
Advances in Polyurethane Biomaterials brings together a thorough review of advances in the properties and applications of polyurethanes for biomedical applications. The first set…Read more
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Advances in Polyurethane Biomaterials brings together a thorough review of advances in the properties and applications of polyurethanes for biomedical applications. The first set of chapters in the book provides an important overview of the fundamentals of this material with chapters on properties and processing methods for polyurethane. Further sections cover significant uses such as their tissue engineering and vascular and drug delivery applications
Written by an international team of leading authors, the book is a comprehensive and essential reference on this important biomaterial.
Brings together in-depth coverage of an important material, essential for many advanced biomedical applications
Connects the fundamentals of polyurethanes with state-of-the-art analysis of significant new applications, including tissue engineering and drug delivery
Written by a team of highly knowledgeable authors with a range of professional and academic experience, overseen by an editor who is a leading expert in the field
materials scientists, chemists, engineers, R&D managers in industry and academia
Related titles
List of contributors
Woodhead Publishing Series in Biomaterials
Preface
Part One. Chemistry, processing and applicationsof polyurethane biomaterials
1. Hierarchal structure–property relationships of segmented polyurethanes
1.1. Introduction
1.2. Structure of segmented polyurethanes
1.3. Soft segment chemistry
1.4. Hard segment chemistry
1.5. Microphase separation
1.6. Compositional effects on mechanical properties
1.7. Compositional effects on degradation rate
1.8. Summary and future perspectives
2. Surface characterization techniques for polyurethane biomaterials
2.1. Friction measurement
2.2. Contact angle
2.3. X-ray photoelectron spectroscopy
2.4. Secondary ion mass spectrometry
2.5. Scanning electron microscopy
2.6. Protein adsorption test
2.7. Hemocompatability measurement
2.8. Antimicrobial efficacy test
2.9. Antibiofilm efficacy
3. Design of biodegradable polyurethanes and the interactions of the polymers and their degradation by-products within in vitro and in vivo environments
3.1. Fundamentals of polyurethane degradation
3.2. Design of new degradable polyurethanes inspired by biodegradation mechanisms
3.3. In vivo testing of polyurethanes from 2005 to 2015
3.4. Coculture using degradable polyurethanes from 2005 to 2015
3.5. Degradable polyurethanes cultured with stem cells for tissue engineering applications
3.6. Degradable polyurethanes used in drug delivery systems
3.7. Physical forms and processing of degradable polyurethanes
3.8. Monomers and oligomers used in degradable polyurethanes
3.9. Summary
4. Novel applications of urethane/urea chemistry in the field of biomaterials
4.1. Introduction
4.2. Citrate-based urethane-doped polyesters
4.3. Waterborne polyurethane biomaterials
4.4. Functionalization of polyurethanes and novel applications of urethane/urea chemistry
4.5. Conclusions and outlook
5. 3D printing of polyurethane biomaterials
5.1. Polyurethane as a candidate material for 3D printing
5.2. Applications of polyurethanes in 3D printing
5.3. Applications of biodegradable polyurethanes in 3D printing
5.4. Low-temperature printing process of waterborne biodegradable polyurethanes
5.5. Conclusion
6. Nanoparticle-induced phenomena in polyurethanes
6.1. Introduction
6.2. Preparation of composites
6.3. Morphology
6.4. Structure
6.5. Nanoparticle-induced self-assembly
6.6. Mechanical behavior
6.7. Thermal behavior
6.8. Flame retardancy
6.9. Antimicrobial activity
6.10. Biomedical application of nanocomposites
6.11. Conclusions
7. Polyurethane nanoparticles, a new tool for biomedical applications?
7.1. Introduction
7.2. Synthesis of polyurethane nanoparticles
7.3. Polyurethane nanoparticles as drug delivery systems
7.4. Polyurethane nanoparticles as diagnosis tools
7.5. Polyurethane nanoparticles as theranostic tools
7.6. Future trends
8. Polyurethanes for controlled drug delivery
8.1. Introduction
8.2. Chemistry of polyurethanes
8.3. Use in drug delivery
8.4. Conclusion and future directions
Abbreviations
9. Antibacterial polyurethanes
9.1. Introduction
9.2. Antiadhesive polyurethanes
9.3. Bactericidal polyurethanes
9.4. Other strategies of antibacterial polyurethanes and future perspectives
Part Two. Polyurethanes for vascular applications
10. Regulating blood cell adhesion via surface modification of polyurethanes
10.1. Introduction
10.2. Blood–material interactions
10.3. Surface–liquid interactions
10.4. Chemical surface modification
10.5. Physical surface modification
10.6. Conclusion
11. Enhancing polyurethane blood compatibility
11.1. Introduction
11.2. Structural characteristics of segmented polyurethanes as blood-compatible materials
11.3. Utilizing bioactive molecules for surface modification to prevent thrombus formation
11.4. Modification of PU with functional groups
11.5. Blending of a polymer with a PC group to improve blood compatibility
11.6. Concluding remarks
12. Antimicrobial polyurethanes for intravascular medical devices
12.1. Introduction
12.2. PUs in intravascular applications
12.3. Infections associated with intravascular devices
12.4. Pathogenesis of intravascular device–related infections
12.5. Prevention of intravascular device–related infections
12.6. Future perspectives
13. Polyurethanes for cardiac applications
13.1. Introduction: cardiovascular diseases
13.2. Polyurethanes in cardiovascular applications
13.3. Polyurethanes in heart valve replacement
13.4. Cardiac tissue engineering/regenerative medicine
13.5. Polyurethane devices for drug delivery in cardiovascular applications
17.2. Techniques for constructing polyurethanes scaffolds
17.3. Strategies to impart antibacterial activity to polyurethanes
17.4. Conclusions and future directions
18. Interaction of cells with polyurethane scaffolds
18.1. Introduction
18.2. Interaction of cells with fibrous polyurethane scaffolds
18.3. Interaction of stem cells with microporous polyurethane scaffolds
18.4. Interaction of cells with other types of polyurethane scaffolds
18.5. Current challenges to understanding the effect of polyurethane scaffold properties on cell fate
18.6. Future perspectives
19. Electrospun fibrous polyurethane scaffolds in tissue engineering
19.1. Introduction
19.2. Electrospinning technique and apparatus
19.3. Factors that affect the electrospinning process
19.4. Methods to enhance cellular infiltration of electrospun scaffolds
19.5. Electrospun polyurethane scaffolds in tissue engineering applications
19.6. Summary and future trends
20. Embolic applications of shape memory polyurethane scaffolds
20.1. Introduction
20.2. Embolization and occlusion
20.3. Why shape memory polymer scaffolds?
20.4. The future of shape memory polymer scaffolds
21. Scaffolds of biodegradable block polyurethanes for nerve regeneration
21.1. Introduction
21.2. Experimental procedures
21.3. Results and discussion
21.4. Conclusions
22. The use of biodegradable polyurethane in the development of dermal scaffolds
22.1. Introduction
22.2. Why are dermal substitutes necessary?
22.3. Skin structure and function
22.4. The ideal dermal substitute
22.5. Development history of NovoSorb™ biodegradable temporizing dermal matrix for major burn injury
22.6. Proof of concept of cultured composite skin on biodegradable temporizing dermal matrix
22.7. Human trials
22.8. The first use of biodegradable temporizing dermal matrix in moderate to severe burn repair
22.9. Conclusions
Index
No. of pages: 718
Language: English
Edition: 1
Published: January 23, 2016
Imprint: Woodhead Publishing
Hardback ISBN: 9780081006146
eBook ISBN: 9780081006221
SC
Stuart L. Cooper
Research interests: Polymer Science and Engineering, Properties of Polyurethanes and Ionomers, Polyurethane Biomaterials, Blood-Material Interactions, Tissue Engineering. Recently awarded AIChE Founders Award for Outstanding Contributions to the Field of Chemical Engineering
Affiliations and expertise
Professor, Chemical & Biomolecular Engineering, Ohio State University