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Eukaryotic Transcription Factors
5th Edition - September 12, 2007
Author: David S. Latchman
Language: English
Hardback ISBN:9780123739834
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eBook ISBN:9780080561035
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Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease…Read more
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Transcription, or the process by which DNA produces RNA, is a central aspect of gene expression. Transcription factors regulate transcription during development and in disease states. As such, it is critical for researchers to gain a good understanding of the relationship between the structure of various families of transcription factors and their function, as well as roles in human disease. Since publication of the Fourth Edition, there have been major advances, notably in the areas of chromatin remodeling and genome-scale analyses. This complete update includes all new coverage of the latest developments, from enabling genomic technologies to studies on the importance of post-translational modifications beyond phosphorylation events.
Potential of transcription factors as therapeutic targets in human disease
Importance of histone modifications
Use of genome-based sequence analysis and high-throughput methods
Applications of the chromatin immunoprecipitation (ChIP) assay
Transcriptional elongation
Regulation by post-translational modifications
Regulatory networks and bioinformatics
A mandatory resource for any researcher or student in the life sciences
DNA sequences, transcription factors and chromatin structureMethods for studying transcription factorsRNA polymerases and the basal transcriptional complexFamilies of DNA binding transcription factorsActivation of gene expression by transcription factorsRepression of gene expression by transcription factorsRegulation of transcription factor synthesisRegulation of transcription factor activityTranscription factors and human disease
No. of pages: 488
Language: English
Edition: 5
Published: September 12, 2007
Imprint: Academic Press
Hardback ISBN: 9780123739834
eBook ISBN: 9780080561035
DL
David S. Latchman
Affiliations and expertise
Master of Birkbeck, University of London, Professor of Genetics, Birkbeck and University College London, UK
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