Nuclear Medicine and Biology

Nuclear Medicine and Biology

Official Journal of the Society of Radiopharmaceutical Sciences





Editor-in-Chief:William C. Eckelman, PhD





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Aims & Scope

Nuclear Medicine and Biology publishes original research addressing all aspects of radiopharmaceutical science: synthesis, in vitro and ex vivo studies, in vivo biodistribution by dissection or imaging, radiopharmacology, radiopharmacy, and translational clinical studies of new targeted radiotracers. The importance of the target to an unmet clinical need should be the first consideration. If the synthesis of a new radiopharmaceutical is submitted without in vitro or in vivo data, then the uniqueness of the chemistry must be emphasized.

These multidisciplinary studies should validate the mechanism of localization whether the probe is based on binding to a receptor, enzyme, tumor antigen, or another well-defined target. The studies should be aimed at evaluating how the chemical and radiopharmaceutical properties affect pharmacokinetics, pharmacodynamics, or therapeutic efficacy. Ideally, the study would address the sensitivity of the probe to changes in disease or treatment, although studies validating mechanism alone are acceptable. Radiopharmacy practice, addressing the issues of preparation, automation, quality control, dispensing, and regulations applicable to qualification and administration of radiopharmaceuticals to humans, is an important aspect of the developmental process, but only if the study has a significant impact on the field.

Contributions on the subject of therapeutic radiopharmaceuticals also are appropriate provided that the specificity of labeled compound localization and therapeutic effect have been addressed. Supplemental information on the Aims and Scope can be found in each print issue of the Journal and at www.nucmedbio.com.

Further Information on the Aims and Scope of Nuclear Medicine and Biology

Introduction: In keeping with the goal of translating the preclinical studies to the clinic, the introduction of your manuscript should contain the potential impact of the molecular probe on a particular disease.Materials and Methods: Given that validation of new targeted radiotracers is a primary goal of the journal, all new chemical entities should have radiochemical yield (RCY), radiochemical purity (RCP), specific activity (SA) and effective specific activity (ESA) at a stated time. Optional information includes organic volatiles, apyrogenicity and sterility. If not commercially available, the precursor should have identity and purity reported for the molecule. All metrics listed above should have an associated average value, standard deviation and number of studies. Dual-modality studies should follow the same criteria for both probes. For small-animal images, the amount injected, the anesthesia used and the image duration should be included in the figure caption so comparisons can be easily made. Correlation with tissue dissection data is recommended. Manuscripts on pharmacy including those on automation that focus on the apparatus and the computer program should present substantially improved RCY, RCP, SA or ESA; shorter reaction time; or improved analytical techniques compared to the present state of the art. All new pharmacy approaches should be referenced as complying with standard government regulations, or biocompatibility data should be included. Radiation-absorbed dose studies in humans should contain the full data set published as supplementary data. A comparison with small-animal dosimetry data is encouraged. Nuclear Medicine and Biology is the official journal of the Society of Radiopharmaceutical Sciences: http://www.srsweb.org.


Scientists in nuclear medicine, biomedicine, pharmacology, and medicinal chemistry.

Abstracting and Indexing

Applied Health Physiology Abstracts, BIOSIS, Cambridge Scientific Abstracts, Chemical Abstracts, Current Contents/BIOMED Database, Current Contents/Life Sciences, Current Contents/SciSearch Database, EMBASE, Elsevier BIOBASE, Health and Safety Science Abstracts, MEDLINE®, Research Alert, Scopus, Toxicology Abstracts
Editor-in-Chief: William C. Eckelman, PhD Bethesda, MD, USA, Editors: L. Aloj Intituto Nazionale Tumori, Naples, Italy, M. W. Brechbiel National Institutes of Health, Bethesda, MD, USA, H. H. Coenen Forschungszentrum Jülich GmbH, Jülich, Germany, C. S. Cutler Missouri Research Reactor Center, Columbia MO, E. Dadachova Albert Einstein College of Medicine, Bronx, NY, T. R. DeGrado Mayo Clinic, Rochester, MN, F. Dolle Service Hospitalier Frédéric Joliot, Orsay, France, A. Duatti University of Ferrara, Ferrara, Italy, Y. Fujibayashi Fukui Medical University, Fukui, Japan, C. Halldin Karolinska Institute, Stockholm, Sweden, R. Haubner Innsbruck Medical University, Innsbruck, Austria, A. G. Horti Johns Hopkins University, Baltimore, MD, G. D. Hutchins Indiana University School of Medicine, Indianapolis, IN, USA, J. M. Jeong Seoul National University College of Medicine, Seoul, Korea, S. S. Jurisson University of Missouri, Columbia, MO, USA, M. R. Kilbourn University of Michigan Medical School, Ann Arbor, MI, USA, L. Knight Temple University, Philadelphia, PA, USA, H. F. Kung University of Pennsylvania, Philadelphia, PA, K. J. Langen Forschungszentrum Jülich GmbH, Jülich, Germany, J. Link University of Washington, Seattle, WA, R Mairs Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow, Scotland, D. A. Mankoff University of Washington Medical Center, Seattle, WA, USA, C. A. Mathis Presbyterian University Hospital, Pittsburgh, PA, USA, E. Mishani Hadassah Hospital, Hebrew University, Jerusalem, Israel, R. D. Neumann National Institutes of Health, Bethesda, MD, C. Paik National Institutes of Health, Bethesda, MD, USA, B. E. Rogers Washington University School of Medicine, St. Louis, MO, USA, S. W. Schwarz Washington University School of Medicine, St. Louis, MO, M. L. Thakur Thomas Jefferson University, Philadelphia, PA, USA, J. F. Valliant McMaster University, Hamilton, Ontario, Canada, D. Vera University of California San Diego Medical Center, San Diego, CA, USA, W. A. Volkert H.S. Truman Memorial VA Medical Center, Columbia, MO, USA, M. R. Zalutsky Duke University Medical Center, Durham, NC, USA, J. Zubieta Syracuse University, Syracuse, NY, Founder Editor: J. Sternberg
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