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Transporters in Drug Discovery and Development
Detailed Concepts and Best Practice
1st Edition - October 31, 2013
Author: Yurong Lai
Language: English
Hardback ISBN:9781907568213
9 7 8 - 1 - 9 0 7 5 6 8 - 2 1 - 3
eBook ISBN:9781908818287
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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are th…Read more
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Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments.
A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development
Balanced coverage of molecular biology aspects and functional outcomes
State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity
Scientists working in biopharmaceutical science, drug discovery/development in understanding the principles and techniques for testing drug candidates
Membrane transporters and the diseases corresponding to functional defects; P-glycoprotein (P-gp/MDR1)/ABCB1; Multidrug resistance- associated protein 2 (MRP2/ABCC2); Breast cancer resistance protein (BCRP)/ABCG2; The bile salt export pump (BSEP/ABCB11); Organic anion- transporting polypeptides (OATPs/SLCOs); Organic anion, organic cation and zwitterion transporters of the SLC22 and SLC47 superfamily (OATs, OCTs, OCTNs and MATEs); Drug transporters in drug discovery and development; Transporter study methodologies.
No. of pages: 780
Language: English
Edition: 1
Published: October 31, 2013
Imprint: Woodhead Publishing
Hardback ISBN: 9781907568213
eBook ISBN: 9781908818287
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Yurong Lai
Yurong Lai is a senior principal scientist at a US-based pharmaceutical company. He received his M.D. from Fujian Medical University in China and a Ph.D. (Toxicology) from Sapporo Medical University in Japan. From 1998 to 2001, he was a research fellow of Japanese Society for Promotion (JSPS) in Department of Physiopathology, Graduate School of Medicine of Hokkaido University, followed by a position as Research Associate in Department of Pharmaceutics, University of Washington
Affiliations and expertise
A major US pharmaceutical company, USA
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