Organic Synthesis

Organic Synthesis, 3rd Edition

Organic Synthesis, 3rd Edition,Michael Smith,ISBN9781890661403


Academic Press




A synthesis-based approach to learning and teaching organic reactions.

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Key Features

    • New publisher, new edition; extensively updated and corrected
    • Over 950 new references with more than 6100 references in total
    • Over 600 new reactions and figures replaced or updated
    • Over 300 new homework problems from the current literature to provide nearly 800 problems to test reader understanding of the key principles
    • Free molecular modeling software to explore 60 new synthesis-oriented molecular modeling problems; designed to aid visualisation and understanding of organic synthesis


    A reactions oriented course is a staple of most graduate organic programs, and synthesis is taught either as a part of that course or as a special topic. Ideally, the incoming student is an organic major, who has a good working knowledge of basic reactions, stereochemistry and conformational principles. In fact, however, many (often most) of the students in a first year graduate level organic course have deficiencies in their undergraduate work, are not organic majors and are not synthetically inclined.

    To save students much time catching up this text provides a reliable and readily available source for background material that will enable all graduate students to reach the same high level of proficiency in organic chemistry. Produced over many years with extensive feedback from students taking an organic chemistry course this book provides a reaction based approach. The first two chapters provide an introduction to functional groups; these are followed by chapters reviewing basic organic transformations (e.g. oxidation, reduction). The book then looks at carbon-carbon bond formation reactions and ways to ‘disconnect’ a bigger molecule into simpler building blocks.

    Most chapters include an extensive list of questions to test the reader’s understanding. There is also a new chapter outlining full retrosynthetic analyses of complex molecules which highlights common problems made by scientists.

    The book is intended for graduate and postgraduate students, scientific researchers in chemistry


    advanced undergraduates, post graduates, postdocs in organic chemistry and organic synthesis

    Michael Smith

    Affiliations and Expertise

    Department of Chemistry, University of Connecticut, USA

    Organic Synthesis, 3rd Edition

    Retrosynthesis, Stereochemistry, and Conformations

    Acids, Bases and Functional Group Exchange Reactions




    Stereocontrol and Ring Formation

    Protecting Groups

    Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds

    Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds: Enolate Anions

    Synthetic Strategies

    Pericyclic Carbon-Carbon Bond Forming Reactions: Multiple Bond Disconnections

    Ca Disconnect Products: Electrophilic Carbon-Carbon Bond Forming Reactions

    Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds Via Radicals and Carbenes

    Student Syntheses: The First Synthetic Problem

    Disconnection Index

    General Index

    Instructions and code to access Spartan software

    Discount on all Earth,Environment and Energy Titles | Use Promo Code EARTH
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