Organic Synthesis

Organic Synthesis, 4th Edition

Organic Synthesis, 4th Edition,Michael Smith,ISBN9780128007204
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Academic Press



276 X 216

Using a synthesis-based approach to learning and teaching organic reactions, this book combines updated molecular modeling content, problems, and visualizations

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USD 112.50
USD 150.00

Key Features

  • Presents new content, reaction examples, and study problems from recent research
  • Features improved organization, new art, and new chapter content on process chemistry and green organic chemistry
  • Includes valuable study and teaching tools, including chapter review questions and homework problems for students, lecture presentations, and other useful materials for qualified course instructors


Organic Synthesis, Fourth Edition, provides a reaction-based approach to this important branch of organic chemistry. Updated and accessible, this eagerly-awaited revision offers a comprehensive foundation for graduate students coming from disparate backgrounds and knowledge levels, providing them with critical working knowledge on basic reactions, stereochemistry, and conformational principles.

This reliable resource uniquely incorporates molecular modeling content, problems, and visualizations, and includes reaction examples and homework problems drawn from the latest in the current literature. The organization of this new book has been improved to better serve students and professors, and to accommodate important updates in the field.

The first two chapters provide an introduction to functional group exchange reactions, and are followed by chapters reviewing protecting groups, strategies, and basic organic transformations such as oxidation and reduction. The book then covers the reactions required to actually complete a synthesis, exploring carbon-carbon bond formation reactions, pericyclic reactions, and methods to ‘disconnect’ a bigger molecule into simpler building blocks.

Finally, a chapter on combinatorial chemistry has been expanded to include valuable and forward-looking content on process chemistry and green organic chemistry. Slide presentations and answer keys are also available to support instructor use.


Graduate and postgraduate chemistry students and researchers

Michael Smith

Professor of Chemistry, University of Connecticut, USA

Affiliations and Expertise

Department of Chemistry, University of Connecticut, USA

Organic Synthesis, 4th Edition

Chapter 1. Retrosynthesis, Stereochemistry, and Conformations

Chapter 2. Acids, Bases and Functional Group Exchange Reactions

Chapter 3. Protecting Groups

Chapter 4. Synthetic Strategies

Chapter 5. Oxidation

Chapter 6. Reduction

Chapter 7. Hydroboration

Chapter 8. Stereocontrol and Ring Formation

Chapter 9. Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds

Chapter 10. Cd Disconnect Products: S and P Carbanions

Chapter 11. Cd Disconnect Products: Nucleophilic Species That Form Carbon-Carbon Bonds: Enolate Anions

Chapter 12. Pericyclic Reactions: The Diels-Alder Reaction

Chapter 13. Pericyclic Reactions: [m+n]-Cycoadditions, Sigmatropic Rearrangements, Electrocyclic and Ene reactions

Chapter 14. Ca Disconnect Products: Electrophilic Carbon-Carbon Bond Forming Reactions

Chapter 15. Carbon Radical Disconnect Products: Formation of Carbon-Carbon Bonds Via Radicals and Carbenes

Chapter 16. Metal-Mediated Reactions

Chapter 17. Process Chemistry and Combinatorial Chemistry

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