Fermentation and Biochemical Engineering Handbook

Fermentation and Biochemical Engineering Handbook, 3rd Edition

Fermentation and Biochemical Engineering Handbook, 3rd Edition,Celeste M. Todaro,Henry C. Vogel,ISBN9781455725533

Todaro   &   Vogel   

William Andrew




276 X 216

Complete and up-to-date coverage of the wide-ranging techniques and applications of fermentation in biochemical engineering, aimed at scientiests and engineers working in a diverse range of industry sectors: chemicals, pharmaceuticals, food, biofuels, etc.

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Key Features

  • Fully updated to cover the latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery, along with developments in instrumentation
  • Industrial contributors from leading global companies, including Merck, Eli Lilly, Amgen, and Bristol-Myers Squibb
  • Covers synthetic processes for both small and large molecules


A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, Fermentation and Biochemical Engineering Handbook emphasizes the operation, development and design of manufacturing processes that use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes-data collection, scale-up parameters, equipment selection, troubleshooting, and more. They also provide relevant perspectives for the different industry sectors utilizing fermentation techniques, including chemical, pharmaceutical, food, and biofuels.

New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes, and in situ real-time fermentation monitoring with wireless technology. It addresses topical environmental considerations, including the use of new (bio)technologies to treat and utilize waste streams and produce renewable energy from wastewaters. Options for bioremediation are also explained.


Engineers and scientists in the chemical and pharmaceutical industries who use fermentation techniques in production. Development, design, engineering and production personnel in the fermentation industry. 

Information about this author is currently not available.
Information about this author is currently not available.

Fermentation and Biochemical Engineering Handbook, 3rd Edition

Part I
1. Fermentation Pilot Plant
2. Mammalian Cell Culture System
3. Bioreactors for Plant Cell Tissue and Organ Cultures
4. Nutritional Requirements in Fermentation Processes
5. Fermentation for Biofuels and Bio-Based Chemicals

Part II
Equipment Design
6. Fermentation Design
7. Agitation

Part III
8. Filtration
9. Cross-Flow Filtration
10. Distillation for Recovery of Biofuels and Bio-Based Chemicals
11. Solvent Extraction
12. Evaporation
13. Centrifugation
14. Drying

Part IV
15. Crystallization
16. Chromatography

Part V
Plant Operations
17. Water Systems for Pharmaceutical Facilities
18. Sterile Formulation
19. Environmental Concerns
20. Instrumentation and Control Systems
21. Statistical Methods for Fermentation Optimization

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