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Biomaterials and Medical Device - Associated Infections
1st Edition - November 4, 2014
Editors: L Barnes, Ian Cooper
Language: English
Hardback ISBN:9780857095978
9 7 8 - 0 - 8 5 7 0 9 - 5 9 7 - 8
eBook ISBN:9780857097224
9 7 8 - 0 - 8 5 7 0 9 - 7 2 2 - 4
Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation…Read more
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Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection.
Provides analysis of biofilms and their relevance to implant associated infections.
Assesses technologies for controlling biofilms.
Considers advantages and disadvantages of in vivo infection studies.
Materials scientists and engineers concerned with producing infection resistant/antimicrobial materials, microbiologists and orthopaedic clinicians.
List of contributors
Woodhead Publishing Series in Biomaterials
Part One: Introduction to biomaterials and medical device-related infections
1: Introduction to biomaterials and medical device-associated infections
Abstract
1.1 History of biomaterials
1.2 Overview of current medical devices and applications
1.3 Overview of problems associated with medical devices
1.4 Introduction to the structure of this book
References
2: Biofilms and implant-associated infections
Abstract
2.1 Introduction
2.2 Microbial profile of implant-associated infections
2.3 Relevance of biofilms in implant-associated infections
2.4 Structure and composition of biofilms
2.5 Pathogenesis of biofilm infection
2.6 Future trends
2.7 Further information and advice
References
3: In vivo infection studies
Abstract
3.1 Introduction
3.2 Legitimacy of animal studies
3.3 Choosing the right animal model to study device-associated infections
3.4 Pros and cons of in vivo infection studies
3.5 Correlation of outcome between animal and clinical studies
3.6 Conclusion and future trends
3.7 Sources of further information and advice
Acknowledgments
References
4: Diagnosis of biofilm-associated infections in medical devices
Abstract
4.1 Introduction
4.2 Importance of detection of biofilm
4.3 Sites of biofilm formation
4.4 Collection of samples for biofilm detection
4.5 Examples of methods for the detection of biofilms associated with infections
4.6 Future trends
4.7 Conclusion
Acknowledgement
References
5: Diagnosis and treatment of implant-associated infections
Abstract
5.1 Introduction
5.2 Risk factors and prevention
5.3 Diagnosis
5.4 Treatment
5.5 Future trends
References
Part Two: Technologies and materials for controlling biofilms
6: Surface modification of biomaterials for biofilm control
Abstract
6.1 Introduction
6.2 Principles of bacterial cell–biomaterial surface interactions
6.3 Substrate specific biological response
6.4 Looking at nature for inspiration
6.5 Modifications to prevent initial stages of bacterial adhesion
6.6 Methods to prevent irreversible attachment of microorganisms
6.7 Mitigation of biofilm formation by attached organisms
6.8 Future trends
References
7: Surface nanoengineering for combating biomaterials infections
Abstract
7.1 Introduction
7.2 Modification of surface nano topography to inhibit bacterial adhesion
7.3 Surface functionalization with eluting antibacterial agent
7.4 Surface functionalization with anti-adhesive polymers
7.5 Immobilization of bactericidal moieties on surfaces
7.6 Conclusion and future trends
7.7 Sources of further information and advice
References
8: Bioactive biomaterials for controlling biofilms