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Biotechnology and the Environment
 
 

Biotechnology and the Environment, 1st Edition

Research Needs

 
Biotechnology and the Environment, 1st Edition,Gilbert S. Omenn,Albert H. Teich,ISBN9780815511052
 
 
 

  &      

William Andrew

9780815511052

179

229 X 152

Proceedings from an EPA workshop on research needs involving biotechnology.

Print Book

Hardcover

In Stock

Estimated Delivery Time
USD 72.95
 
 

Description

Proceedings from an EPA workshop on research needs involving biotechnology.

Readership

Environmental engineers and scientists.

Gilbert S. Omenn

Albert H. Teich

Biotechnology and the Environment, 1st Edition

Part I Workshop Summary
Worshop Summary
Gilbert S. Omenn and Albert H. Teich
Introduction and Background
Key Concerns and Recommendations
Environmental Effects
Health Effects
Monitoring and Quality Assurance
Control Technologies
Part II Papers
Research Plan for Test Methods Development For Risk Assessment of Novel Microbes Released Into Terrestrial and Aquatic Ecosystems
Al Bourquin and Ramon Seidler
I. Introduction
A. Goal
B. Risk Assessment
C. Two Major Approaches
1. Data Base Development
2. Research
D. Short and Long Term Needs
E. Relevance to EPA Needs
II. Novel Organisms
III. Development of Test Methods for the Detection, Identification, and Enumeration of Novel Organisms
A. Statement of Research Problems
B. Availability of Data Base
C. Approaches
1. Conventional Techniques
2. Molecular Techniques
D. Short Term Products
E. Long Term Products
IV. Developments of Test Methods for Assessing Fate of Novel Organisms
A. Statement of Research Problems
B. Availability of Data Base
C. Approaches
1. The Microcosm Approach
2. Rationale for Selecting Ecosystems
a. Terrestrial Research
b. Aquatic Research
D. Short Term Products
E. Long Term Products
V. Development of Test Methods for Assessing Genetic Stability of Novel Organisms
A. Statement of Research Problems
B. Availability of Data Base
C. Approaches
1. Naked Plasmid DNA in Novel Organisms
2. Stability of Plasmid DNA in Novel Organisms
3. Approaches
D. Short Term Products
E. Long Term Products
VI. Development of Test Methods for Assessing Hazards of Released Novel Organisms
A. Statement of Research Problems
B. Availability of Data Base
C. Approaches
D. Short Term Products
E. Long Term Products
VII. Summary
VIII. Acknowledgements
IX. Literature Cited

Biotechnology Health Assessment Research Plan
Marvin Rogul and John R. Fowle III
I. Introduction
II. Health Effects Work Group Panel Recommendations
A. Data Gathering and Information Management
B. Selection of Organisms for Validating Subpart M Test Approach
C. Protocol Development for Infectivity, Pathogenicity, and Metabolic Characteristics of Recombinant Microorganisms
D. Bacterial Pathogenicity Categories
E. Establishment and Management of a Data Base of Characteristics of the Potential Hazards of Genetically Modified Materials
F. Selection and Assessment of Safe Hosts
G. Development of Molecular Probes
III. Discussion
A. Risk Assessment
B. Foundation Laid by the NIH Recombinant DNA Advisory Committee
1. E. coli Studies Which Influenced the Development of the RAC Guidelines
2. Experiments Simulating High Risk Conditions, Promoting and Detecting Genetic Interchange
IV. References

Environmental Engineering Research Support Proposal
John Burckle and Albert D. Venosa
I. Legislation
II. Regulatory Needs
III. Overall Program Approach
IV. Summary of Proposed Environmental Engineering Efforts Related to Regulatory Needs
A. Regulatory Needs
B. Program Structure
C. Proposed Approach
D. Development of Engineering Information and Methodology for Risk Assessment, Reduction and Management for Genetically Engineered Microorganisms in Biologically Based Manufacturing Processes and Deliberate Environmental Release
1. Accidental and Deliberate Release from Biologically Based Manufacturing Processes
2. Deliberate Release Into the Environment

Monitoring Techniques For Genetically Engineered Microorganisms
David Glaser, Tim Keith, Peg Riley, Geoff Chambers, John Manning, Susan Hattingh and Ralph Evans
I. Introduction
II. Sampling Considerations
A. Introduction
B. Qualitative Sampling
C. Desorption from Sediments
D. Enrichment
E. Partitioning in the Environment
F. Issues in Sampling Methods
III. Monitoring Techniques
A. Conventional Microbiological Techniques
B. Immunological Techniques
1. Standard Methods of Antibody Production
2. Monoclonal Methods of Antibody Production
C. The Use of Genetic Markers
D. Molecular Techniques
1. Restriction Enzyme Mapping
2. DNA Probes
3. DNA-DNA Hybridization
4. Genomic Sequencing
IV. Microcosm Test for Monitoring Techniques
A. Microcosm Construction
B. Microcosm Methodology
C. Sample Protocol
D. Containment
E. Points to Consider
V. Quality Assurance
A. Introduction
B. Testing for Sensitivity and Specificity
C. Testing for Linkage Between Markers and rDNA
D. Summary
VI. Conclusion
A. Monitoring Techniques
B. Scenarios for Protocol Development
C. Research Needs
VII. Literature Cited
Appendix: List of Participants
 
 
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