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Advances in Medicinal Chemistry

  • 1st Edition, Volume 5 - December 27, 1999
  • Editors: A.B. Reitz, S.L. Dax
  • Language: English
  • Hardback ISBN:
    9 7 8 - 0 - 7 6 2 3 - 0 5 9 3 - 3
  • eBook ISBN:
    9 7 8 - 0 - 0 8 - 0 5 2 6 7 7 - 5

Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relati… Read more

Advances in Medicinal Chemistry

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Volume 5 of Advances in Medicinal Chemistry contains four intriguing and detailed accounts of the close interface between synthetic chemistry, structure-activity relationships, biochemistry, and pharmacology. In Chapter 1, there is a comprehensive survey of the immunophilin area specifically focussing on neuroregenerative applications in the central nervous system. In Chapter 2, there is an overview of the development of a potent analgesic compound that works via modulation of neuronal nicotinic acetylcholine receptors. In Chapter 3, there is a description of dopamine D-2 autoreceptor partial agonists as potential therapy for the treatment of schizophrenia. In Chapter 4, there is a summary of the successful program in which potent non-peptide inhibitors of HIV protease from the AIDS virus were developed.