As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to measure insulin accurately by immunoasay, and the development of microchemical techniques for studying cells and their components, many research volumes, symposium reports, and original papers have been produced. This explosion of interest has probably had at least three stimuli:
1. the inherent scientific interest in understanding secretion of the pancreatic ß-cell
2. the ß-cells relevance to a very common disease
3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association.
As a result of all this activity, detailed scientific literature including research reviews are readily available.
Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.
The Biology of the Pancreatic &Bgr;-Cell, 1st Edition
Contents. List of Contributors. Preface (S.L. Howell). Section1 &Bgr;-CellCell Development, Replication, and Death. Developmental Biology of the &Bgr;-CellCell (J.M.W. Slack). Pancreatic &Bgr;-Cell Lines: Their Roles in &Bgr;-Cell Research and Diabetes Therapy (S.J. Persaud). &Bgr;-Cell Dysfunction and Death (D.L. Eizirik and A. Hoorens). Islet Proteins Implicated in Pathogenesis of Type 1 Diabetes Mellitus (M.R. Christie). Section II Cellular Mechanisms of Insulin Synthesis and Secretion. Insulin Gene Expression (K. Docherty). Proinsulin Processing and Insulin Storage (C. Wasmeier, J.W.M. Creemers, R.S. Jackson, and J.C. Hutton). Mechanism of Insulin Exocytosis (R. Regazzi). Section III Regulation of Insulin Secretion. Potentiators and Inhibitors of Insulin Secretion (B. Ahren). Signal Recognition: Glucose and Primary Stimuli (E. Van Schaftingen and F. Schuit). Ion Channel Signal Transduction in Pancreatic &Bgr;-Cells (A.S. Rajan and L. Aguilar-Bryan). Signal Transduction: Regulation of Insulin Secretion by Changes in Ca2+
Concentration and Action in Pancreatic &Bgr;-Cells (J. Henquin, J. Jonas, Y. Sato, P. Detimary, and P. Gilon). Roles of Phospholipids and Phospholipase Activiation in &Bgr;-Cell Function (S.A. Metz). Signal Transduction: Protein Phosphorylation and the Regulation of Insulin Secretion (P.M. Jones, S.J. Persaud, and T.E. Harris). Section IV Conclusion. Future Challenges in &Bgr;-Cell Research (S.L. Howell). Index.