Dopamine

Preface

1: Thalamostriatal synapses—another substrate for dopamine action?
Abstract

1 The “Other” Striatal Input

2 Thalamostriatal Targets

3 Formation and Function of Thalamostriatal Synapses

4 Impact of Thalamic Changes in Parkinson's Disease on the Motor System

5 Spine Loss in Striatal Neurons After Dopamine Removal
Acknowledgments

2: Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior
Abstract

1 Introduction

2 Effects of Juvenile Methylphenidate + Fluoxetine Treatment on Gene Regulation in the Striatum

3 Effects of Juvenile Methylphenidate + Fluoxetine Treatment on Molecular Signaling in the Midbrain and Behavior

4 Discussion and Conclusions
Acknowledgments

3: The role of learning-related dopamine signals in addiction vulnerability
Abstract

1 Background

2 Model-free and Model-based Learning from Rewards

3 Phasic Dopamine Signals Represent Model-free Prediction Errors

4 Behavioral Characteristics of Model-free and Model-based Choices

5 Individual Variability

6 Addiction
Acknowledgments

4: Dopaminergic function in relation to genes associated with risk for schizophrenia: translational mutant mouse models
Abstract

1 Introduction

2 Mice Mutant for Dopamine-Related Genes

3 Mice Mutant for DTNBP1 (dysbindin-1)

4 Mice Mutant for NRG1/ErbB

5 Gene × Environment and Gene × Gene Interactions

6 Conclusions
Acknowledgments

5: Dopamine D2 heteroreceptor complexes and their receptor–receptor interactions in ventral striatum: novel targets for antipsychotic drugs
Abstract

1 Introduction

2 Allosteric Receptor–Receptor Interactions in Heteroreceptor Complexes

3 On the Interface of Receptor Heteromers

4 Adenosine A2AR–DA D2R Heteroreceptor Complexes

5 DA D2–neurotensin NTS1 Heteroreceptor Complexes

6 DA D2–5-HT2A Heteroreceptor Complexes

7 5-HT2A–mGluR2 Heteroreceptor Complexes

8 D2–oxytocinR Heteroreceptor Complexes

9 Summary and Future Directions
Acknowledgments

6: The multilingual nature of dopamine neurons
Abstract

1 The Particular Nature of Dopamine Neurons

2 Discovery of Cotransmitters in DA Neurons

3 Localization of Glutamatergic and Mixed Phenotype DA Neurons in the Brain

4 Synaptic Connectivity and Plasticity of Glutamate Release by DA Neurons

5 Developmental Role of Glutamate Release by DA Neurons

6 Possible Contribution of VGLUT2 in DA Neurons to Vesicular Synergy

7 Does Glutamate Corelease Mediate a Reward-Relevant Signal?
Acknowledgments

7: Imaging dopamine neurotransmission in live human brain
Abstract

1 Molecular Imaging Techniques

2 Basic Principles and Receptor Kinetic Models

3 Single-Scan Dynamic Molecular Imaging Technique

4 Use of Multiple Kinetic Models

5 Study of Pathophysiology of Psychiatric Conditions

6 Limitations and Future Directions

7 Summary
Acknowledgments

8: Dopamine receptor heteromeric complexes and their emerging functions
Abstract

1 Introduction

2 The Dopamine D1 Receptor and D2 Receptor Heteromer

3 The Dopamine D2 Receptor and Ghrelin Receptor Heteromer

4 The Dopamine D2 Receptor and Adenosine Receptor Heteromer

9: Alcohol: mechanisms along the mesolimbic dopamine system
Abstract

1 The Reward Systems in the Brain

2 The Mesolimbic Dopamine System

3 The Cholinergic–Dopaminergic Reward Link

4 Addictive Behaviors

5 The Role of Dopamine in Reward

6 The Effects of the Dopamine Stabilizer (−)-OSU6162 on Alcohol Consumption in Rodents

7 The Role of Different Reward Nodes for Alcohol Reward

8 The Role of the Cholinergic–Dopaminergic Reward Link for Reward Induced by Addictive Drugs and Behavior

9 Alcohol and Ligand-gated Ion Channels

10 A Possible Role of Gut–brain Peptides for Drug Dependence

11 Conclusions
Acknowledgments

10: The role of dopamine in huntington's disease
Abstract

1 Introduction

2 Striatal DA Innervation in the HD Postmortem Brain

3 Neurochemistry

4 DA Receptors

5 DA in Genetic Animal Models of HD

6 Synaptic Electrophysiology in HD Models

7 DA and Synaptic Plasticity in HD

8 DA and Excitotoxicity

9 Mechanisms of DA Dysregulation

10 DA Agonists and Antagonists as Treatments for HD

11 Conclusions and Future Directions
Acknowledgments

11: Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings
Abstract

1 Introduction

2 Behavioral Effects of D3 Blockade in Animal Model of Drug Addiction

3 Translating the D3 Hypothesis into Clinical Intervention

4 Conclusion

12: Effects of prenatal exposure to cocaine on brain structure and function
Abstract

1 Introduction

2 Results

3 Conclusions
Index
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