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Functional Neural Transplantation III
 
 

Functional Neural Transplantation III, 1st Edition

Primary and Stem Cell Therapies for Brain Repair, Part I

 
Functional Neural Transplantation III, 1st Edition,Stephen B. Dunnett,Anders Bjorklund,ISBN9780444595751
 
 
 

Progress in Brain Research

Dunnett   &   Bjorklund   

Elsevier

9780444595751

448

235 X 191

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Print Book

Hardcover

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USD 288.00
 
 

Key Features

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Description

This issue of Progress in Brain Research is split over 2 volumes, bringing together cutting-edge research on functional neural transplantation. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.

Readership

Neuroscientists, psychologists, neurologists

Stephen B. Dunnett

Affiliations and Expertise

Cardiff University, Cardiff, UK

Anders Bjorklund

Affiliations and Expertise

Lund University, Lund, Sweden

View additional works by Anders Bjorklund

Functional Neural Transplantation III, 1st Edition

Series Page

Contributors

Chapter 1. Introduction (Part I)

References

Chapter 2. Transplantation in the future

1. Constraints

2. Future directions

Chapter 3. Ethical challenges for using human cells in clinical cell therapy

1. Introduction

2. Challenges, ethical, and others

3. Scientific challenges and ethics

4. Societal concerns: legal and economic issues

5. Meeting ethical challenges and three theses

6. Stages and stage-related challenges

7. Concluding remarks

References

Chapter 4. Banking stem cells for research and clinical applications

Abbreviations

1. Introduction

2. What are cell banks and why are they important?

3. Banking cells for clinical application

4. Testing and characterization of cell banks

5. The international landscape and cell standardization

6. Conclusions and future perspectives

References

Chapter 5. Survival, differentiation, and connectivity of ventral mesencephalic dopamine neurons following transplantation

1. Introduction

2. Survival of DA neurons in VM grafts

3. Differentiation and composition of VM grafts

4. Connectivity of VM grafts

5. Closing remarks

References

Chapter 6. Electrophysiological investigations of synaptic connectivity between host and graft neurons

1. Introduction

2. The desired functional phenotype: Electrophysiological properties of A9 dopaminergic neurons

3. In vivo versus in vitro grafting schemes

4. Electrophysiological properties of stem cell-derived dopaminergic neurons

5. Maturation versus functional integration

6. Correlations between functional integration and behavioral recovery

7. Pitfalls of assessing functional integration in grafting experiments

8. Concluding remarks and future perspectives

References

Chapter 7. Nigral grafts in animal models of Parkinson’s disease. Is recovery beyond motor function possible?

1. Introduction

2. Nonmotor symptoms in PD: The role of DA

3. Nonmotor symptoms in PD: The restorative capacity of fetal transplants

4. Modeling PD in animals: What have we learned about the role of DA?

5. Nonmotor dysfunction and fetal tissue grafts in rodent models

6. Challenges in the field

7. Conclusions

References

Chapter 8. L-DOPA- and graft-induced dyskinesia following transplantation

1. Introduction

2. The clinical phenomena of LID

3. Graft-induced dyskinesia

4. Conclusion

References

Chapter 9. Current status of clinical trials of neural transplantation in Parkinson’s disease

1. Introduction

2. The proof of the concept: Previous trials of fetal neural transplants in PD

3. The state of the art: What have we learned from trials of neural grafting in PD?

4. State of the art: Further considerations in the design of the next generation of neural transplantation trials in PD

5. What do we need to look for? Defining outcome measures for future neural transplantation trials in PD

6. What do natural history studies tell us about relevant outcome measures and end points in clinical trials in PD?

7. The future: The clinical application of SC therapy in PD

8. Conclusion

References

Chapter 10. In vivo imaging of the integration and function of nigral grafts in clinical trials

Abbreviation

1. Introduction

2. Nigral graft survival and relevance to motor symptoms

3. Nigral graft function and DA release

4. Integration of nigral graft with the host brain

5. Graft-induced dyskinesias

6. Patient selection

7. Monoaminergic systems and nonmotor symptoms

8. Inflammatory and immune responses

9. Iron deposition

10. Conclusions and future directions

References

Chapter 11. Neuropathology in transplants in Parkinson’s disease

1. Introduction

2. Parkinson’s disease

3. Neural grafting in Parkinson’s disease

4. Postmortem studies of grafted Parkinson patients

5. Possible mechanisms underlying lewy pathology in grafts

6. Implications of Parkinson-like pathology in grafts for the cell therapy field

7. Concluding remarks

References

Chapter 12. Derivation of dopaminergic neurons from pluripotent stem cells

1. Introduction

2. Why a PSC source?

3. How to define mDA neuron identity from PSC sources?

4. Mouse PSCs

5. Human PSCs

6. Methods of neural induction

7. Rosette-based dopamine neuron differentiation

8. Floor plate-based dopamine neuron differentiation

9. Some of the remaining challenges

References

Chapter 13. Characterization and criteria of embryonic stem and induced pluripotent stem cells for a dopamine replacement therapy

1. Introduction

2. Characterizing human pluripotent stem cell quality and safety for cell therapy in PD

3. The relevance of pluripotent stem cell-derived DA neurons for cell therapy in PD

4. Embryonic stem cells and induced pluripotent stem cells

5. Prioritizing assays to monitor pluripotent stem cell quality

6. Examining chromosomal disruption in pluripotent stem cells

7. Determining genetic mutations in pluripotent stem cells that compromise safety and function of A9 DA neurons

8. Yield of differentiated A9 DA neurons to confirm pluripotent stem cell quality

9. Conclusion

References

Chapter 14. Skilled motor control for the preclinical assessment of functional deficits and recovery following nigral and striatal cell transplantation

Abbreviations

1. Introduction

2. Species similarities

3. Tests of skilled hand use

4. Skilled reaching in experimental models of PD

5. Effects of grafts in experimental models of PD

6. Skilled reaching in experimental models of HD

7. Effects of grafts in experimental models of HD

8. Conclusions

References

Chapter 15. Role of experience, training, and plasticity in the functional efficacy of striatal transplants

1. Introduction

2. Defining the key factors in the experimental model

3. Experimental support for the role of experience, training, and plasticity in the functional efficacy of striatal transplants

4. Do the experimental data have clinical relevance?

5. Conclusion

References

Chapter 16. In vivo imaging of integration and function of striatal grafts in rodent and nonhuman primate animal models

Abbreviation

1. Introduction

2. Magnetic resonance imaging principles

3. Positron emission tomography

4. Conclusion

References

Chapter 17. Clinical trials of neural transplantation in Huntington’s disease

1. Introduction

2. Studies leading to clinical transplantation of human striatal cells

3. Principles from preclinical work pertinent to interpreting clinical studies

4. Constraints and design issues of clinical neural transplant studies

5. What has emerged from clinical studies of neural transplantation in HD?

6. What have we learned from postmortem studies?

7. What is the current status of clinical neural transplantation and what are the next steps?

References

Chapter 18. Derivation of striatal neurons from human stem cells

Abbreviations

1. Introduction

2. The developing and adult striatum

3. Human stem cell sources for HD cell therapy

4. Telencephalic and striatal differentiation of human pluripotent stem cells

5. Stem cell-derived striatal neurons’ derivation, integration, and function

6. Conclusion

References

Combined Index

Other volumes in PROGRESS IN BRAIN RESEARCH

 
 
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