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Studies in Natural Products Chemistry
 
 

Studies in Natural Products Chemistry, 1st Edition

 
Studies in Natural Products Chemistry, 1st Edition,Atta-ur- Rahman,ISBN9780444595300
 
 
 

A Rahman   

Elsevier

9780444595300

9780444595386

544

229 X 152

A valuable resource for researchers and engineers working in natural product and medicinal chemistry

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Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural product and medicinal chemistry

Description

Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry

Atta-ur- Rahman

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan. Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions. He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003-06), and was again elected President of Pakistan Academy of Sciences in January 2011. He was the Federal Minister for Science and Technology (14 March 2000 - 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions. Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University. He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.

Affiliations and Expertise

University of Karachi, Pakistan

View additional works by Atta-ur- Rahman

Studies in Natural Products Chemistry, 1st Edition

Contributors

Preface

Studies in Natural Products Chemistry edited by Atta-ur-Rahman

Chapter 1 Phytoestrogens: “Estrogene-Like” Phytochemicals

Introduction

Phytoestrogens

Absorption and Bioavailability of Phytoestrogens

Phytoestrogens “Estrogen-Like” Activities

Health and Phytoestrogens

Dietary Supplements

Safety Aspects

Conclusion

Chapter 2 The Discovery and Synthesis of Brevisamide

Introduction

Total Syntheses of Brevisamide

Formal Total Syntheses of Brevisamide

Biosynthesis of Brevisamide

Summary

Chapter 3 Recent Asymmetric Syntheses of Tetrahydroisoquinolines Using “Named” and Some Other Newer Methods

Asymmetric Bischler–Napieralski Cyclization–Reduction Syntheses

Asymmetric Pomeranz–Fritsch and Related Reactions

Asymmetric Pictet–Spengler Syntheses

Metal-Catalyzed Cyclizations

Conclusions

Chapter 4 1-Methoxy-Canthin-6-One and Related ß-Carbolines: From Natural Compound to Synthesis and Biological Activities

Introduction

1-Methoxy-Canthin-6-One: Extraction from Natural Source

1-Methoxy-Canthin-6-One: Synthetic Procedures

Biological Properties of 1-Methoxy-Canthin-6-One and Related ß-Carbolines

Conclusion

Chapter 5 Fern Acylphloroglucinols: Structure, Location, and Biological Effects

Introduction

Structural Features of Fern Acylphloroglucinols

Acylphloroglucinols from Dryopteris and Related Genera

Monomers

Dimers and Polymers

Terpenylated Acylphloroglucinols

Elaphoglossum Acylphloroglucinols

Phytochemical and Botanical Considerations

Improvement of Detection and Isolation Procedures

Final Remarks

Chapter 6 Mitogen-Activated Protein Kinase and Natural Phenolic Compounds in Cardiovascular Remodeling

Introduction

Cardiac Remodeling

Vascular Remodeling

MAPK Pathways

ERK Subfamily

p38 Subfamily

c-Jun Kinase

Upstream Activators of MAPK Families, GPCR and Small G-Proteins

Angiotensin Receptors

Epidermal Growth Factor Receptor

Endothelin System

Mitochondrial ROS Production and MAPK Pathway

NADPH and MAPK Pathway

Phenolic Compounds as New Therapeutic Agents for Targeting MAPKs

Conclusion

Chapter 7 Chemistry and Biological Activity of Diterpenoid Alkaloids

Introduction

Results and Discussion

Material and Methods

Chapter 8 Novel Plant-Derived Biomedical Agents and Their Biosynthetic Origin

Introduction

Chapter 9 Histone Deacetylases as Cancer Chemoprevention Targets for Natural Products

Introduction

The Role of HDACs in Carcinogenesis

HDACi from Natural Sources

The Role of Sirtuins in Carcinogenesis

Modulators of Sirtuins from Natural Sources

Biological Assays

Chapter 10 Natural Products: Strategic Tools for Modulation of Biofilm Formation

Introduction

Surface Active Natural Products

Natural Products in Biofilm Regulation Mechanisms

Microbial Natural Products

Marine Organisms

Plants

Animals

Conclusion

Chapter 11 Medicinal Herbs and Plant Extracts for Influenza: Bioactivity, Mechanism of Anti-influenza Effects, and Modulation of Immune Responses

Introduction

Bioactivity

Mechanisms of Antiviral Effects Against Influenza

Modulation of Immune Responses

Conclusion

Chapter 12 Bioactive Compounds from Marine Gorgonian Corals

Introduction

Bioactive Compounds from Marine Gorgonians

Conclusion

Acknowledgments

Chapter 13 Natural Herbicides as a Safer and More Environmentally Friendly Approach to Weed Control: A Review of the Literature Since 2000

Introduction

Agriculture and Weeds

Agricultural Uses

Nonagricultural Uses

Conclusions

Chapter 14 Recent Approaches Towards Selected Lamiaceae Plants for Their Prospective Use in Neuroprotection

Introduction

Rosmarinus officinalis L.

Scutellaria baicalensis Georgi

Salvia L.

Conclusion

Chapter 15 Phytochemicals

Introduction

An Ancient Scourge: Tuberculosis

The Next Catastrophe: TB Tsunami

The Culprit: Mtb

Current Drugs

Need for Alternative and Integrative Forms of Treatment

Drug Targets of Current Drugs

Structure–Activity Relationships

Synergism

Conclusion

Index

Quotes and reviews

"There is a good mix of chemistry, structure elucidation, synthesis, and biology in the various chapters, thereby appealing to a diverse readership. The diagrams are clear and the writing excellent. In summary, this is another excellent volume in a very valuable series on natural products for which Professor Atta-ur-Rahman is to be congratulated...... an important and essential asset for those libraries supporting the efforts of natural product research groups." --Geoffrey A. Cordell, University of Illinois, Chicago, USA, PHYTOCHEMISTRY, Vol.65, 2004

 
 
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