11th International Symposium on Process Systems Engineering - PSE2012, 1st Edition

Preface

PSE2012 Committees

A Perspective on Energy and Sustainability

1 Introduction

2 Carbon Management

3 Emissions Reduction

4 Smart Manufacturing

5 Fuel Switching

6 Biofuel

7 Conclusions

Optimizing the end-to-end value chain through demand shaping and advanced customer analytics

1 Introduction

2 Related Literature

3 Customer Choice Model

4 Demand Shaping Optimization

5 Numerical Experiments

6 Conclusion

Bio-based Value Chains of the Future - An Opportunity for Process Systems Engineering

1 Introduction

2 Designing bio-based processes - need for a paradigm shift?

3 Toward an incremental strategy for integrated design of value chains

4 Conclusions

Process Systems Engineering

Process Intensification in Water and Wastewater Treatment Systems

1 Introduction

2 Surface Water Treatment

3 Desalination

4 Wastewater Treatment and Reuse

5 Waste-to-value

6 Zero Liquid Discharge

7 Integrated System Design Framework

8 Conclusion

Applications of Technology Roadmapping to Planning and Building Systems for Medicine and Vaccine Manufacturing

1 Introduction

2 Global Operations Level Systems Views

3 Stakeholder maps, trends, drivers and key performance indicators

4 Technology inventories

5 Technology Management Process

6 The Technology and PSE portfolio and network management

7 Conclusion

Multi-scale Optimization for Advanced Energy Processes

1 Introduction and Motivation

2 Paradigm for Reduced Order Models

3 ROM-based Optimization with Detailed Model Gradients

4 ROM-based Optimization without Detailed Model Gradients

5 Conclusions and Future Work

PSE in China

1 Introduction

2 Retrospect on 20 years of PSE developments in China

3 Challenges for future development of PSE

4 Future Prospects

Recent Developments on Pse Education and Research in Malaysia

1 Introduction

2 PSE Education in Malaysia

3 Showcase Innovation in PSE Education - Co-operative Problem-Based Learning (CPBL) Approach in Process Control

4 Research and Development in PSE in Malaysia

5 Conclusion

Opportunities for Energy Savings in Azeotropic Separation Processes

1 Introduction

2 Azeotropic Separation Processes via Distillation

3 Two Industrial Examples via Different Separation Methods

4 Further Energy Savings via Heat Integration

5 Conclusions

6 Acknowledgment

Process Systems Engineering Approach to Synthesis of Batch Chemical Processes

1 Introduction

2 A brief description of problems addressed

3 Solution procedure

4 Case study I

5 Case study II

6 Conclusion

The Role of PSE Community in Meeting Sustainable Freshwater Demand of Tomorrow’s World via Desalination

1 Introduction

2 State of the Art: MSF Desalination Process

3 State of the Art: RO Desalination Process

4 State of the Art: Hybrid MSF/RO Desalination Process

5 State of the Art: Use of Renewable Energy in MSF and RO Process

6 State of the Art & Future Challenge: Environmental Impact Modelling

7 Opportunities for the PSE Community

LNG Processing

1 Introduction

2 Natural Gas Liquefaction

3 LNG Storage and Regasification

4 Process systems engineering in LNG processing

5 Future challenges

6 Conclusion

Research Challenges in Alarm Management for Safe and Stable Plant Operations in Chemical Process Industries

1 Introduction

2 Alarm system evaluation by event correlation analysis

3 Alarm system evaluation by a virtual subject

4 Conclusion

Uncertainty propagation in condensate stabilization column

1 Introduction

2 Uncertainty propagation

2.1 Monte Carlo Sampling

2.2 Latin Hypercube Sampling

2.3 Emulator

3 Results

4 Conclusion

A multi-scale model of naphtha pyrolysis process

1 Introduction

2 Establishment of multi-scale model

3 The information communications between different scales

4 Conclusions

Simulation and Optimization of Saponification Process in Propylene Oxide Plant

1 Introduction

2 Process Description

3 Process Optimization

4 Conclusions

Simulation Studies and Sensitivity Analysis of Methyl Tert-butyl Ether Reactive Distillation

1 Introduction

2 Description of the MTBE Column

3 Results and Discussion

4 Conclusion

Optimal Design of HMX recrystallization process using supercritical carbon dioxide as antisolvent

1 Introduction

2 GAS process

3 Base-case design and optimization of the entire process

4 Concluding Remark

5 Acknowledgement

Thermal integration of a hot process stream on distillation columns through a side-reboiler

1 Introduction

2 Available heat duty of a hot process stream

3 Calculation procedure

4 Conclusions

Forecasting Naphtha Price Crack Using Multiple Regression Analysis

1 Introduction

2 Problem statement

4 Modeling

4 Results

6 Conclusion

Model-based development of optimal reaction concepts for plant wide process intensification

1 Introduction and methodological approach

2 Example process: Oxygen based ethylene oxide synthesis

3 Modeling

4 Results

5 Conclusion

6 Acknowledgments

Hierarchical simulation of integrated chemical processes with a web based modeling tool

1 Introduction into hierarchical simulation

2 Workflow for hierarchical modeling in MOSAIC

3 Case studies

4 Conclusion

Modeling and Simulation of a Catalytic Distillation Process for Production of Ethylene Glycol Monobutyl Ether

1 Introduction

2 Process characteristic

3 Modeling of CD column

4 Results and discussions

5 Conclusion

Use of reactive distillation for triacetin production from crude glycerol

1 Introduction

2 Process Description

3 Simulation Results

4 Conclusions

Dynamic modeling of direct contact membrane distillation processes

1 Introduction

2 Dynamic modeling of a plate-and-frame direct contact MD module

3 Case study

4 Conclusions

2-D Population Balance Modelling of Nucleation and Growth of Needle-shape Crystals

1 Introduction

2 2-D PBE Model Incorporating Crystal Growth and Nucleation Kinetics

3 A Constant Crystal Growth Rate Case

4 A Constant Nucleation and Crystal Growth Rate Case

5 A Nonlinear Crystallization Kinetics Case

6 Conclusions

Dynamic analysis of reaction kinetics of carton packaging pyrolysis

1 Introduction

2 Methodology

3 Results and Discussion

Conclusions

A simultaneous synthesis method for combined heat and mass exchange networks

1 Introduction

2 Problem Statement

3 Proposed Method

4 Case study

5 Conclusion

6 Acknowledge

A New Method To Determine The Optimum Heat Exchanger Network Approach Temperature

1 Introduction

2 Methodology

3 Case Study 1

4 Conclusion

Product Driven Process Design Method

1 Introduction

2 A Product-driven Process Synthesis (PDPS) Approach in Foods

3 Conclusions

Sensitivity of Process Design due to Uncertainties in Property Estimates

1 Introduction

2 Methodology

3 Case Study: Sensitivity of extractive distillation design

4 Conclusions

An integrated quantitative index of stable steady state points in chemical process design

1 Introduction

2 Process design approach

3 Case study

4 Conclusion

Applicability of product-driven process synthesis to separation processes in food

1 Introduction

2 Applications of PDPS in the food industry

3 Applicability of PDPS for a separation process

4 Case study: Separation of isoflavones from okara

5 Conclusion

Simultaneous optimization of hydrogen network with desulfurization processes embedded

1 Introduction

2 Novel modeling and optimization approach

3 Case study

4 Conclusions

A Systematic Methodology for Design of Emulsion Based Chemical Products

1 Emulsion Based Chemical Product Design – An Introduction

2 A Systematic Methodology for Emulsified Product Design

3 A Conceptual Case Study - A Sunscreen Lotion

4 Conclusions and Future Work

Molecular Design using Three-Dimensional Signature Descriptors

1 Theoretical Background

2 Signature Descriptors for Molecular Design

3 Case Study - Design of Alkyl Substituent for Rice Plant Fungicide

4 Conclusions

Optimization design of RO system for water purification

1 Introduction

2 RO unit model

3 RO network representation

4 Solution methodology

5 Illustrative example

6 Conclusions

Retrofit of Heat Exchanger Networks Including the Detailed Equipment Design

1 Introduction

2 Development

3 Example

4 Conclusions

Production of Cylohexane from Hydrogenation of Benzene using Microreactor Technology

1 Introduction

2 Reactor design for Production of Cyclohexane

3 Process Improvement (i.e Optimization) Studies

4 Results and Discussion

Synthesis Framework of Biorefinery Systems for Lignocellulosic Biorenewables

1 Introduction

2 Literature Review

3 Superstructure for a General Biorefinery

4 Mathematical Formulation

Conclusions

Heat-integrated reactive distillation for biodiesel production from Jatropha oil

1 Introduction

2 Biodiesel production from Jatropha oil

3 Simulation results

4 Conclusions

5 Acknowledgement

Functional modeling applied to HAZOP automation

1 Introduction

2 D-higraphs: merging function and structure

3 D-higraphs environment and HAZOP Assistant

4 Kerosene recovery unit (case study)

5 Comparison with other methodologies

6 Conclusions and further work

Dynamic Flexibility Analysis with Differential Quadratures

1 Introduction

2 Applications

3 Conclusions

A Method of Designing Plant Alarm Systems with Hierarchical Cause-Effect Model

1 Introduction

2 Hierarchical CE Model

3 Design of Plant Alarm System using Hierarchical Cause-Effect Model

4 Conclusion

Computer Aided Assessment of Occupationally Healthier Processes during Research and Development Stage

1 Introduction

2 Occupational Health Assessment Methods

3 The Inherent Occupational Health Index

4 Development of Systematic Computer Aided IOHI Tool

5 Case Study on Methyl Methacrylate

6 Conclusion

A Performance Assessment Method for Feedback Control Loops in Chemical Processes with Distribution Outputs

1 Introduction

2 Modeling of Chemical Processes with Distribution Outputs

3 PDF of the Individual Distribution Values

4 PDF of the Distribution Output

5 Case Study

6 Conclusions

Fault Diagnosis based on DPCA and CA

1 Motivation

2 Fundamentals

3 Experimental Setup

4 Analysis of the Tuning Parameters.

5 Conclusions

Design Method of Alarm System for Identifying Possible Malfunctions in a Plant Based on Cause-Effect Model

1 Introduction

2 Cause-effect model

3 Alarm variable selection method

4 Case study

5 Conclusion

Real-time application of CAPE-OPEN for PTA process monitoring and optimization*

1 Introduction

2 Rigorous Model Validation

3 Online Process Monitoring and Modeling Platform Deployment

4 Conclusion

Towards Holistic Decision Support Systems

1 Introduction

2 Holistic vs reductionist approach — including systematically HOF

3 The importance to move to an experimental approach

4 Performance assessment

5 An industrial use case

6 Conclusions

Sensor Location for water systems

1 Introduction

2 Sensor Network Design Problem

3 Stochastic Approach

4 Application Examples

5 Conclusions

Quantitative Risk Analysis of New Energy Stations by CFD-Based Explosion Simulation

1 Introduction

2 Comparison of explosion simulation models

3 Explosion scenario

4 Results

5 Conclusions

Knowledge-based attributes generation for data-driven fault diagnosis in process systems

1 Introduction

2 Method

3 Case Study

4 Conclusions

5 Acknowledgements

Pattern Recognition using Multivariate Time Series for Fault Detection in a Thermoeletric Unit

1 Introduction

2 Application Scenario

3 The methodology

4 Results

5 Conclusion

Compressive Strength Prediction of Concrete Recycled Aggregates made from Ceramic Tiles using Feedforward Artificial Neural Network (FANN)

1 Introduction

2 Methodology

3 Result and Discussion

4.0 Conclusion

5.0 Acknowledgement

Control of integrated unit operations

1 Main Text

2 Energy integration in distillation

3 Control strategies for Divided-Wall Columns

4 Process studied

5 Conclusions

Nonlinear Control Strategies for a Micro-Aerobic, Fermentation Process

1 Introduction

2 Modeling and Controller Design

3 Simulation Results

4 Conclusion

Real Time Model Predictive Control of a Four Tank Interacting Storage System

1 Introduction

2 Model of Four Tank Liquid Storage System

3 Derivation of DMC controller for Liquid Storage System

4 Derivation of Nonlinear DMC

5 Results and Discussion

6 Conclusion

Approximate Dynamic Programming based control for Water Gas Shift reactor

1 Introduction

2 Mathematical model and simulation of WGS Reactor

3 Online Control using Approximate Dynamic Programming (ADP)

4 Conclusion

Comparison of MIMO MPC and PI Decoupling in Controlling Methyl Tert-butyl Ether Process

1 Introduction

2 MTBE Reactive distillation

3 Control Development

4 Results and Discussion

5 Conclusion

MPC for LPV systems using perturbation on control input strategy

1 Introduction

2 Problem Description

3 The proposed MPC algorithm for LPV systems

4 Example

5 Conclusions

Systematic Specification of a Logic Controller for a Delayed Coking Drum1

1 Introduction

2 Systematic Logic Controller Design

3 Example Process

4 Conclusions

A Mixed Integer Quadratic Reformulation of the Quadratic Assignment Problem with Rank-1 Matrix

1 Introduction

2 Problem formulation

3 Testproblems

4 Results

5 Conclusions

Uncertainty evaluation for multivariate industrial processes

1 Introduction

2 Methods

3 *Uncertainty* module

4 Case Study: a CSTR

5 Conclusions

Frequency and Identification

1 The issue

2 A simple case to illustrate

3 Discussion

4 Conclusions

Real-time optimization of energy systems in sugar and ethanol facilities

1 Introduction

2 Real-Time Optimization

3 Sugar and ethanol energy system model

4 Results

5 Conclusions

On the Stability and Feasibility of Model Predictive Control

1 Introduction

2 Criteria for feasibility and stability

2.1 Computational Schemes for stability parameter

3.Numerical results

4 Conclusion

Studying Various Optimal Control Problems in Biodiesel Production in a Batch Reactor under Uncertainty

1 Introduction

2 Optimal Control Problem:

3 Result and discussion

4 Conclusions

Neural Network Predictive Control of a Tubular Solid Oxide Fuel Cell

1 Introduction

2 Model description

3 Results and discussion

4 Control of the SOFC System

5 Conlusion

Novel MILP-based optimization method for heat exchanger network retrofit considering stream splitting

1 Introduction

2 MILP-based iterative method for HEN retrofit

3 Case study

4 Conclusions

Simulation based Heuristics Approach for Plantwide Control of Propane Precooled Mixed Refrigerant in Natural Gas Liquefaction Process

1 Introduction

2 Description of C_{3}MR Process Plant

3 Dynamic Simulation and Heuristic Methods

Studying the effect of feed composition variation on typical natural gas liquid (NGL) recovery processes

1 Introduction

2 Case study

Conclusion

Techno-Economic Analysis for the Synthesis of Downstream Processes from the Oxidative Coupling of Methane Reaction

1 Introduction

2 Brief description of the processes

3 Results and discussions

4 Conclusions

Targeting industrial heat pump integration in multi-period problems

1 Introduction

2 Methodology

3 Example and conclusions

4 Acknowledgements

Thermodynamic analysis of homogeneous non-isothermal mixing influence on the water-using networks’ energy target

1.Introduction

2 The classification of streams and of stream mixing

3 The influences of homogeneous stream mixings on water-using network's energy target

4 An application example

5 Conclusions

Optimal Process Configurations of Bioethanol Dehydration for Different Ethanol Inlet Concentrations and Throughputs

1 Introduction

2 Process Description

3 Results

4 Conclusion

A comparison between the two balancing regimes of the natural gas market in the Netherlands

1 Introduction into the Dutch gas market and its balancing regime

2 The old and new balancing regime

3 Modeling the two balancing regimes of the natural gas market

4 Model results and insights

5 Final remarks

6 Acknowledgements

Model predictive control for BioPower combined heat and power (CHP) plant

1 Introduction

2 Description of the process and model predictive control strategy for Biopower 5 CHP plant

3 Test results of MPC control strategy of BioGrate boiler

4 Conclusions

Exergetic optimization of a refrigeration cycle for natural gas liquefaction

1 Introduction

2 Materials and Methods

3 Results and Discussion

4 Results and Discussion

Theoretical analysis ofa multi-stage membrane reactor for oxidative coupling of methane

1 Introduction

2 Theory

3 Results and Discussion

4 Conclusions

5 Acknowledgement

Optimal synthesis for the feed-water-heater network of a Pulverized Coal (PC) power to minimize water consumption

1 Introduction

2 Process Description

3 Optimization under uncertainty

4 Heat Exchange Network synthesis for water management

5 Conclusion

Techno-economic analysis of coal gasification based co-production systems

1 Introduction

2 Conceptual structure of the co-production system

3 Modeling and simulation of the co-production system

4 Analyses of the co-production system

5 Conclusion

A Process Integration Technique for Steam System Synthesis Involving Multiple Levels

1 Introduction

2 Problem Statement

3 Flowrate Targeting

4 HEN Layout

5 Illustrative Example

6 Conclusion

Modeling the dissolution of carbonate minerals utilized in Flue Gas Desulfurization scrubbers. A stepwise titration technique applied to low Grashof-Reynolds ratio.

1 Introduction

Modeling

3 Materials and methods

5 Conclusions

6 Acknowledgements

Optimal Multi-Objective Planning of Distributed Biorefinery Systems Involving Economic, Environmental and Social Aspects

1 Introduction

2 Problem Statement

3 Model Formulation

4 Case Study

5 Conclusions

Bi-objective MINLP optimization of an industrial water network via benchmarking

1 Introduction

2 Benchmarking in bi-objective optimization

3 Case study

4 Conclusion

A Graphical Approach to Optimal Source-Sink Matching in Carbon Capture and Storage Systems with Reservoir Capacity and Injection Rate Constraints

1 Introduction

2 Problem Statement

3 Methodology

4 Case Study

5 Conclusion

Fugitive Emission Reduction through Optimization

1 Introduction

2 Development of fugitive emissions mitigation model

3 Results and Discussions

4 Conclusion

Process modeling and economic analysis of microalgal systems for CO2 capture and production of chemicals

1 Introduction

2 Model Development and Analytical Methodology

3 Results and Discussion

4 Conclusions

Sustainability Assessment of CO2 Capture Process in the Preliminary Process Design

1 Introduction

2 Sustainability Assessments

3 Conclusions

Characterization of moisture and free air space effects and the optimal operation of a composting process for minimal waste and energy use

1 Introduction

2 Process Description

3 Emission of Exhaust Gases

4 Conclusion

Post-Combustion CO2 Capture Process with Aqueous MEA

1 Introduction

2 Typical CO_{2} Capture Process using Aqueous MEA

3 Advanced MEA Process using a Phases Separation Heat Exchanger

4 Simulation Results

5 Conclusion

6 Acknowledgement

A superstructure model of water-using network synthesis with multiple contaminants for batch processes and its solution

1 Introduction

2.Model Establishment and Solution

3 Case study

4 Conclusions

Effects of greenhouse gas emission on decentralized wastewater treatment and reuse system

1 Introduction

2 Methodology

3 Case Study

4 Conclusions

Nomenclature

Optimal Membrane Desalination Network Synthesis with Detailed Water Quality Information

1 Introduction

2 Synthesis Approach

3 Accounting multiple water quality parameters

4 Accounting for boron removal requirements

5 Enhanced economical assessment considerations

6 Mathematical Formulation & Implementation

7 Case Study

7 Conclusions

Modeling and Simulation of CO2 Absorption with Amine Component Solvent

1.1 Introduction

2 Thermodynamic Model

3 Process simulation

4 Conclusions

Life cycle assessment of coal-based methanol

1 Introduction

2 Goal and scope definition

3 Inventory analysis

4 Impact assessment

5 Conclusion

Information integration

1 Introduction

2 D-higraph functional modeling methodology

3 Information integration tool

4 Application

5 Conclusions

Nonlinear Design of Stimulus Experiments for Optimal Discrimination of Biochemical Systems

1 Introduction

2 Approach

3 Numerical Analysis

4 Conclusion

Multi-scale modeling for prediction of distributed cellular properties in response to substrate spatial gradients in a continuously run microreactor

1 Introduction

2 Case Study

3 Model Description

4 Results and Discussion

5 Conclusions

Development of an integrated model for cobalt solvent extraction using Cyanex 272

1 Solvent Extraction modelling background

2 Experimental

3 Model Construction

4 Future work

Fast simulation of annual optical efficiency of solar tower power plant

1 Introduction

2 The numerical model of the optical efficiency

3 Implementation details

4 Simulation Results

5 Conclusion

A Numerical Analysis for Total Site Sensitivity

1 Introduction

2 Methodology

3 Demonstration **Case Study**

4 Conclusion

Study on a New type of Gas–liquid Cyclone used in COIL

1 Introduction

2 Device structure and simulation conditions

3 Result and discussion

4 Reaction research

5 Conclusion

Trend analysis for studies of knowledge flow in research on polymeric materials

1 Introduction

2 Method

3 Results

4 Summary

Multidimensional Monte Carlo Cell Population Dynamics in Virus Replication Systems

1 Introduction

2 Model Formulation

3 Simulation Results

4 Conclusion

CFD Analysis of Cavitation in a Crude Oil Pipeline to an Oil Tanker

1 Introduction

2 Experiment

3 CFD Analysis

4 Results

5 Conclusions

Utilisation of Computer Science Design Patterns in Chemical Engineering

1 Computational chemical engineering

2 Software considerations

3 Conclusions

NGL Recovery from CO2-EOR Streams

1 Purpose

2 Introdution

3 Methods

4 Results

5 Conclusions

Integrated Platform at ICES Kilo-Lab for Process Quality by Design

1 Introduction

2 Methodological Framework for Integrated Platform

3 Implementing an Integrated Platform at the Kilo-Lab Facility of the Institute of Chemical and Engineering Sciences (ICES)

Multiphase CFD simulation of an F-T airlift external loop slurry reactor

1 1 Introduction

2 2 Setup and CFD-Approach

3 3 Optimization of gas distribution

4 4 Gas–liquid-solid CFD simulation

5 5 Conclusion

Multi-scale process and supply chain modelling: from feedstock to process and products

1 Introduction

2 Multiscale Process Modelling and the Supply Chain

3 Conclusion

Performance Assessment of Water Gas Shift Membrane Reactors by a Two-dimensional Model

1 Introduction

2 Mathematical Model

3 Results and Comments

4 Conclusions

A Hybrid Meta-heuristic Method for Optimizing Logistic Networks Subject to Operational Conditions in Practice

1 Introduction

2 Problem Statements and Basic Idea for Solution

3 Modified VRP Method with Time Window

4 Numerical Experiment

5 Conclusion

Application of bee colony algorithm for optimization of CCR reforming process

1 Introduction

2 Bee Colony Optimization Algorithm

3 CCR process modeling

4 CCR process optimization

5 Results and discussion

6 Conclusion

A scatter search algorithm for the twin roll caster scheduling problem in aluminum industry

1 Introduction

2 Mathematical model

3 The proposed scatter search algorithm

4 Computational experiments

5 Conclusions

Hydrogen Network Integration with both Pressure and Impurity Constraints

1 Introduction

2 The Method with Pressure Cascade Use and Impurity Diverted Path

3 Case study

4 Conclusion

Modeling and Solving Batch Scheduling Problems with Various Storage Policies and Operational Policies using Timed Automata

1 Introduction

2 Timed Automata Based Modeling

3 Modeling Storage Policies

4 Blocking Reduction

5 Modeling Operational Policies

6 Numerical Results

7 Conclusions

Optimal design of batch-storage network under sporadic operating time loss

1 Introduction

2 Problem Formulation

Steady-state optimization of an industrial high-density polyethylene slurry process based on an equation-oriented molecular weight distribution model

1 Introduction

2 Model development

3 Results and discussion

4.Conclusion

Cyclic Scheduling of Cracking Furnaces System with Real Operational Characters

1 Introduction

2 Problems Statement

3 MINLP Formulations

4 Solution Algorithm

5 Computational Results

6 Conclusions

Thermodynamic analysis and modeling for typical feed-preheating and fractionating processes in delayed cokers

1 Introduction

2 Comparison and thermodynamic analysis of three processes

3 HEN optimization principle through integrating fractionating processes

4 Case study

5 Conclusions

On an Operational Model and a Computer Support Environment for Batch Plants Based on Adaptive Scheduling -Application of simulators to obtain initial conditions for rescheduling-

1 Introduction

2 Basic Concept of the Operational Model

3 Class of Target Production System

4 Operational Method

5 Experiments

6 Conclusions

A Comparison Study of Adjoint-Based Gradient Search Technique and Mathematical Programming for Optimal Well-Placement

1 Introduction and Previous Research

2 Problem Definition

3 Formulation

4 Algorithm

5 Case Study

6 Conclusion

Minimization of storage requirement in a batch process using pinch analysis

1 Introduction

2 Problem definition

3 Minimum storage algorithm (MSA)

4 Mathematical proof

5 Illustrative example: batch water network

6 Conclusion

Targeting Minimum Heat Transfer Fluid Flow for Multiple Heat Demands

1 Introduction

2 Minimum HTF flow rate targeting

3 Illustrative example

4 Conclusions

A Study of Complex Distillation Arrangements for Improved Depropanizing, Debutanizing and Deisobutanizing Fractionation of NGL

1 Introduction

2 Conventional column sequence

3 Proposed base sequence

4 Conclusions

Water condensate collection system by using MINLP model

1 Introduction

2 Water condensate collection with an intermediate heating by using MINLP model

3 Case study

4 Conclusions

Pressure Drop Consideration in Cooling Water Systems with Multiple Cooling Towers

1 Introduction

2 Model development

3 Solution Procedure

4 Case Study

5 Conclusion

New method for large-scale heat exchanger network synthesis

1 Introduction

2 Formulation of the optimization problem

3 New synthesis method

4 Conclusion

Dynamic characteristics of self-heat recuperative distillation process

1 Introduction

2 Self-Heat Recuperative Separation Process

3 Dynamic Characteristics of Self-Heat Recuperative Process

4 Conclusion

Model-Based Optimal Design of Experiments for Determining Reaction Network Structures

1 Problem Statement

2 Methodology

3 Results

4 Conclusion

A continuous hydroformylation process in a miniplant scale

1 Introduction

2 Systematic analysis of the micro emulsion mixture for process and equipment design

3 Mini-plant Design

4 Conclusion

Acknowledgement:

A generic process template for continuous pharmaceutical production

1 Introduction

2 A conceptual generic nitro reduction process template

3 Substrate Adoption Methodology (SAM)

4 Conceptual case study

5 Conclusions

Probabilistic design approach to build the litheness in an integrated process scheme

1 Introduction

2 Case Study

3 Probabilistic Design

4 Conclusions and Path Forward

Integrated optimization of the adsorption of theaflavins from black tea on macroporous resins

1 Introduction

2 Experimental

3 Results and discussion

4 Future work

5 Conclusions

Influence of the organic phase fraction in the biphasic organic-aqueous reactor feed stream on the enzymatic hydrolysis of FAME in a packed bed

1 Introduction

2 Theoretical Approach

3 Experimental Procedure

4 Results and Discussion

5 Conclusions

Statistical Monitoring of Water Systems

1 Introduction

2 Methodology

3 Application Results for the WWTP Benchmark

4 Conclusions

Next-Generation, Integrated Fire Detection and Diagnosis Built Upon the Recent Advances in the Abnormal Situation Management

1 Introduction

2 Fault Detection, Monitoring and Diagnosis System for CNG Stations

3 Fire Detection System Design Based on Multi-sensor Information for Improved Reliability

4 Conclusion: Integrated fire detection and diagnosis

Hierarchical proficiency evaluation system of plant operation for effective operator training

1 Introduction

2 Hierarchical proficiency evaluation

3 Example

4 Conclusions

Simulation study of alternatives for the efficient start-up of dividing-wall distillation column sequences

1 Introduction

2 Dividing-wall distillation column system

3 Simulation of the start-up process

4 Comparison of start-up strategies

5 Conclusion

Model-based system identification and PI controller tuning using closed-loop set-point response

1 Introduction

2 Problem Statement

3 New system identification strategy

4 Case Study

5 Conclusions

Optimization and control of polystyrene batch reactor using hybrid based model

1 Introduction

2 Modeling of polystyrene batch reactors.

3 Results & Discussion

4 Conclusion

Modeling and stochastic dynamic optimization for optimal energy resource allocation

1 Introduction

2 Problem description and model formulation

3 ADP-based approach for deriving an optimal policy

4 Concluding Remarks

Seawater Desalination Processes

1 Introduction

2 Optimization Problem

3 Assumptions and mathematical model

4 Results

5 Conclusions and future work

An Inverse Optimization Approach to Inducing Resource Conservation in Eco-Industrial Parks

1 Introduction

2 Problem Statement

4 Case Study

5 Conclusion

Techno-economic analysis of ethanol production from marine biomass

1 Introduction

2 Process description

3 Materials and methods

4 Results and discussions

Acknowledgement

Modeling and Simulation of Ship Transport of CO2

1 Introduction

2 Description of ship transport chain of CO_{2}

3 Simulation Results and Discussions

4 Concluding Remarks

Design Modification Study on DME direct synthesis technology

1 Introduction

2 Process Simulation Details

3 Result

4 Conclusion

Simulation of an Off-shore Natural Gas Purification Process for CO2 Removal with Gas-Liquid Contactors Employing Aqueous Solutions of Ethanolamines

2 Introduction

3 Model Description

4 Model Performance Evaluation

5 Conclusions

A Comparative Economical Analysis of Technologies for CO2 Removal from Offshore Natural Gas

1 Introduction

2 Methodology

3 Results and Discussion

4 Conclusions

6 Acknowledgement

A Systematic Approach for Optimization of an Algal Biorefinery Using Fuzzy Linear Programming

1 Introduction

2 Fuzzy Linear Programming

3 Case Study

Environmental Metrics

4 Case Study Results and Discussion

5 Conclusion

Process Analysis Using Umberto Carbon Footprint Tool

1 Introduction

2 Process simulator approach

3 Chemical Plant Data aproach

4 Conclusions

Efficient configuration/design of solvent-based post-combustion carbon capture

1 Introduction

2 Process simulation

3 Simulation Results

4 Conclusion

Effect of the microfiltration phase on pervaporation of ethanol produced from banana residues

1 Introduction

2 Materials and methods

3 Results and discussion

4 Conclusions

Virtual and Augmented Reality as Viable Tools to Train Industrial Operators

1 Introduction

2 OTS extension to FOPs through virtual reality

3 Accident events simulation in OTS

4 Augmented Virtual Reality

6 Conclusions

Semantic similarity for case-based reasoning in the context of GMP

1 Introduction

2 Semantic similarity

3 Proposed approach

4 Case Study

5 Conclusions

Computational Fluid Dynamics at work - Design and Optimization of Microfluidic Applications

1 Introduction

2 Materials and Methods

3 Results and Discussion

4 Conclusions

Modeling the Superovulation stage in IVF

1 Introduction

2 In-vitro fertilization:

3 Superovulation:

4 Model details

5 Results:

6 Conclusion

Computational fluid dynamics simulation of the feed distribution system of a falling film distillation device

1 Introduction

2 Methodology

3 Results and Discussions

4 Conclusions

5 Acknowledgements

Author Index

Integration of market dynamics into the design of biofuel processes

1 Introduction

2 Modeling approach

3 Case study: the production of MTHF from deciduous wood

4 Conclusions

Design methodology for bio-based processing

1 Introduction

2 Methodology

3 Case study

4 Conclusions

5 Acknowledgement

Multi-objective Optimization of a Fermentation Process Integrated with Cell Recycling and Inter-stage Extraction

1 Introduction

2 Integrated Fermentation Process and its Model

3 Multi-objective Optimization Problem Formulation

4 Multi-objective Differential Evolution Algorithm

5 Results and Discussion

6 Conclusions

Integrated Design of High Temperature Steam Electrolysis and Biomass to Liquid Fuel Process

1 Introduction

2 Process description

3 Criteria and preliminary results

4 Conclusion

Model-based assessment of algal ponds for biomass production under temperate climates

1 Introduction

2 Mathematical Model

3 Selected Locations and Climate Conditions

4 Simulation Results and Discussion

5 Conclusion

PSE opportunities in biocatalytic process design and development

1 Introduction

2 The development procedure

3 Operating windows

4 Property prediction

5 Micro-scale reactors and Computational Fluid Dynamics (CFD)

6 Economic assessment

7 Future perspectives

Optimal Design of an Algae Oil Transesterification Process

1 Introduction

2 Process Analysis

3 Conclusion

Potential for Bio-based Chemicals Production in Singapore’s Petrochemical Cluster

1 Introduction

2 Bio-based chemicals production

3 PLA production

4 PLA supply chain economic and environmental assessment

5 Conclusions

Multi-Objective, Multi-Period Optimization of Renewable Technologies and storage system Using Evolutionary Algorithms and Mixed Integer Linear Programming (MILP)

1 Introduction

2 Methodology

3 Storage optimisation model

4 Conclusion

5 Acknowledgments

Improved Strains for Biological Treatment of Wastewater

1 Introduction

3 Model Validation

4 Model Analysis

5 Conclusion

In silico Simulation for Enhancing Production of Organic Acids in Zymomonas mobilis

1 Introduction

2 Materials and Methods

3 Results and Discussion

4 Concluding Remarks and Future Work

CFD simulation of cracking tube with internal twisted slices

1 Introduction

2 Modeling Approach

3 Result and discussion

4 Conclusion and prospect

CFD-Based Optimization of a Flooded Bed Bioreactor for Algae Production

1 Introduction

2 Algae Growth Model

3 Optimization Models

4 Nomenclature

5 Acknowledgments

CPFD Simulation for Particle Deposit Formation in Reactor Cyclone of RFCC

1 Introduction

2 CPFD governing equations

3 Simulation conditions

4 Result and discussion

5 Conclusion

CFD-Mass transfer Simulation of an RDC Column

1 Introduction

2 Numerical Background

3 Droplet Size Calculation

4 Mesh Generation and Simulation Setup

5 Simulation Results and Discussion

6 Conclusion and Outlook

Estimation of Primary Variables from Combination of Secondary Measurements

1 Introduction

2 Loss method for estimation

3 Partial Least Square (PLS) Method

4 Kalman filtering

5 Example

6 Conclusions

Validation of an absorber model of carbon dioxide capture in an aqueous amine solvent developed based on the SAFT-VR framework

1 Introduction

2 Proposed model of a CO_{2} absorber

3 Model Validation

4 Results

5 Conclusions

EM Algorithm for Parameter Estimation in Batch Process

1 Introduction

2 Maximum likelihood estimation

3 Implementation of EM algorithm for parameter estimation

4 Simulation

5 Conclusion

6 Acknowledgements

Continuous Discrete Unscented Kalman Filtering for Nonlinear Differential Algebraic Equations Systems

1 Introduction

2 Continuous Discrete Unscented Kalman Filter

3 Results and Discussions

4 Conclusion

Systematic identification of crystallization kinetics within a generic modelling framework

1 Introduction

2 Systematic identification of crystallization kinetics

3 Application of the systematic identification framework

4 Conclusions

Generation of first and higher order derivative information out of the documentation level

1 Introduction

2 Modeling in the documentation level with MOSAIC and derivatives

3 Some numerical results

Dynamic Model Identification with Uncertain Process Variables using Fuzzy Inference System

1 Introduction

2 Fuzzy Inference System (FIS) and dynamic uncertainty

3 Results

4 Conclusion

Coalescence Parameter Estimation in Liquid Extraction Column using OPOSPM

1 Introduction

2 Mathematical Model and Parameter Estimation

3 Results and Discussion

4 Conclusions

Constraint Programming based Input Signal Design for System Identification

1 Introduction

2 Constraint Programming

3 Input signal Design - Problem Formulation:

4 Results & Discussion

Industry Embedded Training in (Bio)Process Systems

1 Introduction

2 Programme Objectives

3 Programme Design

4 Programme Recruitment

5 Concluding Comments

Chemical Engineering Education and Industry Megatrends

1 Introduction to Paradigms and Megatrends in Chemical Engineering

2 Predicting the Future Megatrends and Paradigms

3 Profile of the Future Chemical Engineering Professional

4 Teaching Chemical Engineers to Face the Challenges of the Future

5 Conclusion and discussions

Use of Podcasts for Teaching Process Control

1 Introduction

2 Development of Podcasts

3 Classroom Implementation

4 Assessment

5 Conclusions

6 Acknowledgment

Synthesis of Heat-Integrated Resource Conservation Networks

1 Introduction

2 Problem Statement

3 Model Formulation

4 Case Study

5 Conclusion

Impacts of equipment off-design characteristics on the optimal design and operation of combined cooling, heating and power systems

1 Introduction

2 System configuration of a CCHP system

3 Mathematical formulation of the optimization models

4 Case study

5 Results and discussions

6 Conclusions

Storage of Renewable Energies via Chemical Conversion using CO2

1 Introduction

2 Methanation Process

3 Modeling

4 Optimization

5 Results

6 Outlook

Integrated Biomass Power Plant and Storage for Peak Load Management

1 Introduction

2 Distributed Energy System

3 Mathematical Model

4 Results and Discussions

5 Conclusion

An optimization procedure for retrofitting process energy systems in refineries

1 Introduction

2 The procedure of total site optimization

3 Example

4 Conclusions

Optimization of Performance of Phosphoric Acid Fuel Cell (PAFC) Stack using Reduced Order Model with Integrated Space Marching and Electrolyte Concentration Inferencing

1 Introduction

2 Pafc – Working Principle

3 Hierarchical Optimizer for Pafc Stack

4 Structural Blocks for Optimization

5 Optimization Results

Conclusions

Platform development for studying integrated energy conversion processes

1 Introduction

2 Methodology

3 Application: Power plant with CO_{2} capture

4 Conclusion

Robust Optimization of Microgrids - An Application to Taichung Industrial Park

1 Introduction

2 Proposed Microgrid Model

3 Taichung Industrial Park, Taiwan

4 Results and Conclusion

An optimization of the food quality products throughout the supply chain

1 Introduction

2 Mathematical Model

3 Sample Results

4 Conclusion

Single- & Multi-site Production & Distribution Planning in Food Processing Industries

1 Introduction

2 Mathematical Formulation

3 Case Study

4 Concluding Remarks

Hybrid Approach for Multi-stage Logistics Network Optimization under Disruption Risk

1 Introduction

2 Problem Formulation

3 Hybrid Approach for Solution

4 Numerical Experiment

5 Conclusion

Supply Chain Optimization of Biomass Production Improvement

1 Introduction

2 Model Development

3 Result Analysis

4 Conclusion

Modular Optimization Approach for Process Synthesis and Integration of an Integrated Biorefinery

1 Introduction

2 Problem Statement

3 Study Case

4.Result and Discussion

5.Conclusion

Integrated production and distribution management with cross docking in supply chains

1 Introduction

2 Problem Description

3 Problem Formulation

4 Computational Results

5 Conclusions

6 Acknowledgements

Semantically-enabled Formalisation to Support and Automate the Application of Industrial Symbiosis

1 Introduction

2 Use Case Validation

3 Conclusions and Future Work

Modeling and Optimization of Superstructure-based Stochastic Programs for Risk-aware Decision Support

1 Introduction

2 Modeling Approach

3 Case Study: Electric Grid Operation and Planning

4 Summary

Accessing Direct and Indirect Effects within a LCA Based Multiobjective Synthesis of Bioproducts Supply Chains

1 Introduction

2 Direct, Indirect and Total Effects

3 Industrial Case Study of Biogas Processes

4 Conclusion

Mitigating Supply Disruption for a Global Chemical Supply Chain-Application of Agent-based Modeling

1 Introduction

2 Simulation-based Risk Analysis Approach

Generating disruption scenarios:

Defining possible mitigation actions:

Evaluating SC performance with Agent-based Model:

Analysing the simulation results:

3 An Illustrative Case

4 Concluding Remarks

A Novel Multi-Grid Formulation for Scheduling Semi-Continuous Plants

1 Introduction

2 Problem Statement

3 MILP Formulation

4 Numerical Evaluation

5 Conclusion

A Continuous-Time Approach for Scheduling Bidirectional Pipeline Operations

1 Introduction

2 Mathematical Formulation

3 Case study

4 Conclusions

An iterative MILP-based approach to automated multi-product multi-stage manufacturing systems

1 Introduction

2 Flow shop MILP-based model

3 Two-Stage MILP-based solution approach

4 Application example

5 Conclusions

6 Acknowledgments

Integrated Scheduling and Control of Continuous-Time Blending Processes

1 Introduction

2 Problem class

3 Problem formulation

4 Case Study

5 Conclusions

De-risking Scale-up of a High Shear Wet Granulation Process Using Latent Variable Modeling and Near Infrared Spectroscopy

1 Introduction

2 Modeling methodology

3 Experimental

4 Results

5 Conclusion

Performance Assessment and Benchmarking of Desalination Plants

1 Introduction

2 Energy Assessment and Benchmarking - Methodology

3 MSF Desalination Plant

4 Case Study Results

5 Conclusions

Process Modeling of Bio-Based Production on Interdisciplinary Analysis across Agriculture and Engineering

1 Introduction

2 Specification of modeling requirement

3 Case study: Sugarcane-derived ethanol production

4 Discussion and conclusion

Planning and Scheduling as a Part of a Control System - Implementation Aspects

1 Introduction

2 Production environment

3 Example cases

4 Conclusions

Advances in Procedural Automation in the Chemical Industry

The Chemical Industry- The tale of two business drivers and production systems.

1 Advances in Procedural Operations in Specialty and Fine Chemicals

2 Safety, Operational efficiency, and aging workforce - Bulk Chemicals emerging focus on procedural operations

3 The emergence of a procedural automation standard for the continuous process industries

4 Application of Procedural Automation & Case Example

5 Conclusion

Retrofit design of a pharmaceutical batch process improving green process chemistry & engineering principles

1 Introduction

2 Methodology

3 Case study

4 Results

Parallel design of pharmacodynamic experiments for the identification of antimicrobial-resistant bacterial population models

1 Introduction

2 The methodology

3 Case study

4 Final remarks

Integral Formulation of the Smoluchowski Coagulation Equation using the Cumulative Quadrature Method of Moments (CQMOM)

1 Introduction

2 The Cumulative Quadrature Method Of Moments (CQMOM)

3 Integral formulation of the Continuous Smoluchowski Equation

4 Numerical Results and Discussion

5 Conclusions

Capacity Planning for Continuous Pharmaceutical Manufacturing Facilities

1 Introduction

2 Problem Description

3 Mathematical Formulation

4 Solution Method

5 Results and Discussion

6 Conclusion

Multivariate Analysis of API Particle Size Distribution Variation in a Manufacturing Environment

1 Introduction

2 PSD Baseline Study

3 Principal Component Analysis

4 Conclusions

Long-term Scheduling of a Multi-stage Multi-product Bio-pharmaceutical Process

1 Introduction

2 Problem Statement

3 Mathematical Model

4 Example

5 Conclusion

An advanced model for controlled oral drug delivery

1 Introduction

2 ACAT Model

3 Dissolution Model

4 Results and Discussions

5 Conclusions

Model and analysis of pharmaceutical manufacturing system with government intervention and emergency supply

1 Introduction

2 System model

3 Risk measure

4 Simulation results and analysis

5 Conclusions

Optimization and Control of Crystal Shape and Size in Protein Crystallisation Process

1 Introduction

2 Morphological PB model and the optimisation problem

3 Results and discussion

4 Concluding remarks

Intelligent Decision-Support Tools for Effective and Integrated Operational Planning in Pharmaceutical Plants

1 Introduction

2 Motivation and Challenges

3 Decision Support Framework

4 Principal Features: PlanPerfect

5 Performance Demonstration: PlanPerfect

6 Conclusion

Embedding Methane Steam Reformer and Methanol Reactor into a Single Reactor

1 Introduction

2 Hybrid Reactor Concept

3 Model Development

4 Results And Discussions

5 Conclusion

Characterization and design of a new crystallization process using a model-based approach

1 Introduction

2 Crystallization Modeling and Experiments

3 Parameter Fitting and Model Validation

4 Process Simulations and Simple Optimization

5 Combining hydrodynamics and crystallization kinetics for scale-up

6 Concluding Remarks

A new graphical representation of exergy applied to low temperature process design

1 Introduction

2 Exergy of material streams

3 Exergetic Temperatures

4 New graphical representation of exergy

5 Illustrative example of using the new diagram

6 Remarks

Model based optimal reactor design applied to a free radical polymerization process

1 Indroduction

2 Model Formulation

3 Reaction mechanism

4 Results and Discussion

5 Conclusions

Optimization of carbon dioxide-assisted nanoparticle deposition process with uncertain design space

1 Introduction

2 Materials and methods

3 Results

4 Discussion

5 Conclusion

Modeling and Simulation of Multi-stream Heat Exchanger Using Artificial Neural Network

Introduction

1 First Principal MSHE Model

2 Artificial Neural Network Model Development

3 Results & Discussion

4 Conclusions

Modeling and Analysis of Novel Reactive HiGee Distillation

1 Introduction

2 Design and Simulation of Novel RHD Process

3 Results and Discussion

4.Conclusions

Simulation and Analysis of Carbon-in-Leach (CIL) Circuits

1 Introduction

2 Kinetics of leaching and adsorption

3 CIL model and kinetics

4 Results and Discussion

5 Conclusion

The Numerical Simulation of Pneumatic Drying of Polycarbonate in Vertical Tube

1 Introduction

2 Experimental Setup

3 Description of Model

4 Results and discussion

5 Conclusions

The OPOSPM as a Nonlinear Autocorrelation Population Balance Model for Dynamic Simulation of Liquid Extraction Columns

1 Introduction

2 The OPOSPM as a nonlinear autocorrelation PBM

3 Experimental setup and particle image processing

4 Results and Discussion

5 Conclusions

The Simulation and Analysis of Coal to Liquids Processes

1 Introduction

2 Process configurations

3 Process simulation

4 Process analysis

5 Conclusions

Agent-Based Simulation Framework for Public Bus Fleet Electrification Investment Analysis

1 Introduction

2 Background

3 Methodology

4 Applications

5 Conclusion

Modeling and Control Challenges in the development of Discrete Microfluidic Devices

1 Introduction

2 Modeling opportunities

3 Control opportunities

4 Conclusions

Simulation of Hydrodynamics and Heat Transfer in Confined Jet Reactors of Different Size Scales for Nanomaterial Production

1 Introduction

2 Mathematical formulation

3 Experimental study

4 Simulation of confined jet reactors

5 Results and discussion

6 Concluding remarks

Modeling, Simulation and Experimental Investigation of a Reactive Hybrid Process for the Production of Dimethyl Carbonate

1 Introduction

2 Process analysis tool for the design of reactive hybrid systems

3 Case-Study

4 Conclusion and Outlook

Estimation of Predictive Accuracy of Soft Sensor Models Based on One-Class Support Vector Machine

1 Introduction

2 Method

3 Case Study

4 Conclusion

Methodology for Emergency Shut-Down of Multi-Megawatt Wind Turbine Generators

1 Introduction

2 Low-Order Model for Wind Turbine Generators

3 Emergency Shut-Down Optimization formulation

4 Optimal EST Procedures: Case Study

5 Conclusions and Future Directions

Data-driven causal inference based on a modified transfer entropy

1 Introduction

2.Introduction to transfer entropy and proposed midification

3 Causal inference based on the modified transfer entropy

4 Case study

Conclusion

Data-based Method for Diagnosing Multiple Blockage Locations in a Microreactor with Parallelized Microchannels

1 Introduction

2 Microreactor

3 Identification method of blockage locations

4 Case study

5 Conclusion

Conceptual Framework for Security Hazard Management in Critical Infrastructures

1 Introduction

2 Characteristics of ICS security problem

3 Fault Tree Analysis for threats of cyber terrorism

4 Effects of manipulation and concealment in a zone

5 Conclusion

A simulation based engineering method to support HAZOP studies

1 Introduction

2 Dynamic simulations based Methodology for HAZOP studies

3 Results and discussions Case study of gas re-injection process

4 Conclusion and perspectives

Optimal layout of chemical process using risk index approach to minimize risk to human

1 Introduction

2 Individual Risk

3 Process Layout Optimization based on Risk Analysis

4 Case Study

5 Conclusion

Optimal channel design and sensor placement in flow distributors for detecting blockage of parallelized microreactors

1 Introduction

2 Flow Distribution in Parallelized Microreactors

3 Blockage Detection in Parallelized Microreactors

4 Conclusions

Batch process analysis and monitoring based on an automatic phase identification method utilizing process dynamic information

1 Introduction

2 Methodology

3 Application results

4 Conclusions

Data driven fault detection using multi-block PLS based path modeling approach

1 Introduction

2 Methodology

3 Case studies

4 Results and discussions

5 Conclusions

Optimisation of a Power Plant Utility System Using Process Integration

1 Introduction

2 Mathematical model formulation

3 Results and Discussion

4 Conclusion

Simplified MFE with power-change adaption strategy for the dynamic optimization of HTR-PM *

1 Introduction

2 Opportunity: Observation of element meshes for the optimization of HTR-PM load transition

3 Simplified MFE with power change adaption strategy

4 Numerical results

5 Conclusion

A methodology to forecast the price of commodities

1 Introduction

2 The Methodology

Conclusions

Numerical study of mixed-feedstock pyrolysis

1 Introduction

2 Problem Statement

3 Methodology

4 Result & discussion

5 Conclusion

Generating operating procedures using a micro genetic algorithm

1 Introduction

2 Problem definition

3 Methodology

4 Numeric experiments

5 Conclusions

Optimal Operation of a Membrane Reactor Network

1 Motivation and Problem Statement

2 Model for the CPBMR

3 Stand-alone Operation of the CPBMR

4 Simulation of the Membrane Reactor Network

5 Conclusions and Outlook

Dynamic Optimization of Solution Polymerization Process of Methyl Methacrylate in Batch Reactors

1 Introduction

2 Reaction Kinetics and Dynamic Model

3 Dynamic Optimization Problem Formulation

4 Results and Discussions

5 Conclusions

Optimization of multi-refinery hydrogen networks

1 Introduction

2 Problem statement

3 Model Formulation

4 Case Study

5 Conclusion

Optimizing the PSA process of propylene/propane using Neuro-Fuzzy modeling

1 Introduction

2 PSA Modeling and Simulation

3 PSA Optimization Using Neuro-Fuzzy

4 Optimization Results

5 Conclusion

Rigorous Generation and Model-Based Selection of Future Biofuel Candidates

1 Introduction

2 Fuel requirements and proposed fuel design process

3 Application of the fuel design framework to the gasoline fuel range

4 Conclusions

Reducing drying energy consumption by adsorbent property optimization in multistage systems

1 Introduction

2 Process description, superstructure modeling and optimization

3 Results and Discussion

4 Conclusion

Optimizing Protein-Excipient Interactions for the Development of Aggregation-Reducing Lyophilized Formulations

1 Introduction

2 Methods

3 Results and Discussion

Signature Descriptors for Process and Molecular Design in Reactive Systems

1 Theoretical background

2 Signature descriptors for molecular design

3 Proof of Concept Example

4 Conclusions

5 Acknowledgements

Optimization of Product Formulation through Multivariate Statistical Analysis

1 Introduction

2 Methodology

3 Proof of Concept Example - Polymer Blending

4 Conclusions

Control strategies for flexible operation of power plant integrated with CO2 capture plant

1 Introduction

2 2 Process description

A framework for water footprint optimisation in the bioethanol supply chain

1 Introduction

2 Assumptions and methods

3 Mathematical features

4 Case study

5 Results and discussion

6 Final remarks

Steady-state multiplicity of a biogas production system based on anaerobic digestion

1 Introduction

2 Model based approach

3 Results

4 Conclusions

A Unified Approach for the Optimization of Energy and Water in Multipurpose Batch Plants

1 Introduction

2 Problem Statement

3 Mathematical Formulation

4 Case Study

5 Conclusions

Evaluation of coal-based dimethyl ether production system using life cycle assessment in South Korea

1 Introduction

2 LCA of DME production processes

3 Results of impact assessment and its interpretation

4 Conclusion

Analysis and Modeling of Information Required for Process Assessment on Environment, Health, and Safety by IDEF0 and UML

1 Introduction

2 Method

3 Results and discussion

4 Conclusion

Correlations among Footprints within Biomass Energy Supply-Chains

1 Introduction

2 Description of the Proposed Methodology

3 Case Study of Biomass Energy Supply-Chains

4 Conclusions

Energy Generation and Carbon Footprint of Waste to Energy

1 Introduction

2 Problem Description

3 Utilisation of the waste energy potential

4 Illustrative Example

5 Conclusions and Further Work

Assessing the environmental potential of carbon dioxide utilization

1 Introduction

2 Graphical Targeting Approach

3 Results

4 Conclusions

Simultaneous Water and Energy Minimization for Brown Stock Washing System

1 Introduction

2 Problem Statement

3 Mathematical Model for Brown Stock Washing System

4 Case Study

5 Conclusion

A heuristic approach to design batch water-using networks with multiple contaminants

1 Introduction

2 Problem Statement

3 Concentration Potentials

4 Allocation Principles

5 A Case study

6 Conclusions

7 Acknowledgement

Synthesis of Sustainable Property-Based Water Networks

1 Introduction

2 Model Formulation

3 Results and Discussion

4 Conclusions

Modeling and optimization of water-based polygeneration system

1 Introduction

2 Superstructure Representation

3 Model Formulation

4 Case Study: Water-based polygeneration system in ethylene glycol production

5 Conclusion

Multi-objective Optimization for Integrated Water Network Synthesis

1 Introduction

2 Integrated water network model

3 Multi-objective Genetic Algorithm

4 Case study

5 Conclusions

Synthesis of water networks for processes with mixed batch and continuous units

1 Introduction

2 Problem Statement

3 Solution Approach

4 Superstructure and Model

5 Illustrative Example

6 Concluding Remarks

Optimal operation of reverse osmosis plant driven by solar power without batteries

1 Introduction

2 RO membrane Model

3 Parameter estimation and validation

4 Optimization

5 Conclusion

Optimization of the scheduling and water integration in batch processes based on the Timed Petri net

1 Introduction

2 Optimization of the scheduling and water integration

3 Example

4 Conclusion

A method to find an optimal draw solute for cost-effective FO(forward osmosis) desalination process

1 Introduction

2 Screening method

3 Mathematical models

4 System optimization

5 Case study

6 Conclusions

Optimal water network synthesis with detailed membrane-based regenerator models

1 Introduction

2 Optimization-Based Model Formulation for Water Network Synthesis

3 Detailed Nonlinear First-Principles Model Formulation for Membrane Regenerators

4 Case Study: Water Network in a Petroleum Refinery

A Stochastic Programming Formulation for Disinfectant Booster Station Placement to Protect Large-Scale Water Distribution Systems

1 Introduction

2 Problem Formulation

3 Numerical Results

4 Summary and Conclusions

Incorporating Complex Fiscal Rules in Strategic Planning of Offshore Oil and Gas Fields

1 Introduction

2 Background

3 Model

4 Example

5 Conclusions

Optimization of Pure-Refrigerant Cycle Compressing Ratio on C3-MR Process

1 Introduction

2 Characteristics of C3-MR Process

3 Mathematical Model

4 Simulation results

5 Conclusion

6 Acknowledgement

Monitoring and fault diagnosis system for LNG fractionation process

1 Introduction

2 Backgrounds

3 Case study

4 Results

5 Conclusions

Simultaneous Optimal Placement of Injector and Producer Wells Using Mathematical Programming

1 Introduction

2 Previous works

3 Problem Definition

4 Model

5 Case Study

6 Discussion

7 Conclusion

8 Acknowledgements

Contract selection under uncertainty

1 Introduction

2 Problem Statement

3 Formulation

4 Example

5 Conclusion

A Novel Global Optimization Approach to the Multiperiod Blending Problem

1 Introduction

2 Multiperiod Blending Problem

3 Radix-based Discretization

4 Computational Results

5 Conclusion

Finding an optimized set of transformations for convexifying nonconvex MINLP problems

1 Introduction to the *a*SGO-algorithm

2 The optimization method for transformations

3 An example

4 Results and discussion

5 Acknowledgements

Structured regularization in barrier NLP for optimization models with dependent constraints

1 Introduction

2 Barrier Method Background

3 Constraint regularization and inertia correction

4 Numerical results

5 Conclusions

A Progressive Hedging Approach for Parameter Estimation via Stochastic Nonlinear Programming

1 Introduction

2 Model Formulation

3 Estimation Approach

4 Results & Conclusions

Performance Analysis of Shooting Algorithms in Chance-Constrained Optimization

1 Introduction

2 Chance Constraint Optimization

3 Result recycling for initial estimations

3.1 Nearest neighbour approach

3.2 Affine hull approach

3.3 Derivative approach

4 Enhanced root-finding using Halley's method

5 Numerical tests

6 Conclusion

Multiple Sensor Fault Isolation Using Contribution Plots without Smearing Effect to Non-Faulty Variables

1 Introduction

2 Proposed Approach

4 Conclusions

Integrated Sensor Network Design

1 Introduction

2 Problem Formulation

3 Case study: Evaporator system

4 Conclusion

Reallocation Index Based Sensor Network Designfor Efficient Fault Diagnosis

1 Introduction

2 Previous Related Work

3 Reallocation Index Based Sensor Network

4 Case Study: Tennessee Eastman Process

5 Conclusions

A Graphic Processing Unit (GPU) Algorithm for Improved Variable Selection in Multivariate Process Monitoring

1 Introduction

2 Graphics Processing Unit (GPU) Computing

3 GPU implementation of GA-PCA

4 Application to Tennessee Eastman Challenge Process

5 Conclusions

Proactive Alarms Monitoring using Predictive Technologies

1 Introduction

2 Proactive Alarms Monitoring Scheme

3 Case Study: A Depropanizer Unit

4 Conclusion

Synthesis of Large-scale Multi-stream Heat Exchanger Network Based on Pseudo-temperature Enthalpy Diagram Method Combined with Superstructure Method

1 Introduction

2 Method representation

3 Case Study

4 Conclusion

A New Tool For Simultaneous Targeting And Design Of Heat Exchanger Networks

1 Introduction

2 SePTA for simultaneous targeting and design

3.Conclusion

Heat Exchanger Network Synthesis Using a Hyperstructure of Stagewise Stream Superstructures

1 Introduction

2 MINLP Formulation

3 Examples

4 Conclusion

Improvement in Strategy for Design of Heat Exchanger Networks using Multiagent Framework

1 Introduction

2 Multiagent Framework

3 Simulations and Results

4 Conclusion

Process Heat Exchanger Network Integration and Decomposition via Clustering Approach

1 Introduction

2 Model formulation

3 Case study

4 Conclusions and Future Work

Controllability of three types of dividing wall columns

1 Introduction

2 Model development and column design

3 Results

4 Conclusions

A systematic procedure for synthesis of intensified simple column configurations for multicomponent distillations

1 Introduction

2 The systematic synthesis procedure

3 Synthesis of the ISCs for a five-component mixture

4 Discussion and Conclusion

Design and Control of a Reactive-Distillation Process for Esteriflcation of an Alcohol Mixture Containing Ethanol and n-Butanol

1 Introduction

2 Conceptual Design of the Process Flowsheet

3 Control Strategy Design

4 Conclusions

Design and Control of Reactive Divided Wall Column for Esterification with Mixed n-Amyl alcohol and n-Hexanol Feed

1 Introduction

2 Conceptual Design of the Process Flowsheet

Results and Discussion

3 Control Strategy Development

4 Conclusions

Aggregate models based on the wave propagation theory for high-purity distillation columns

1 Introduction

2 Aggregate model of distillation column

3 Modification of recovery factors in the group method

4 Results and discussion

5 Conclusion

An exergy grand composite curve based procedure for arranging side exchangers on distillation columns

1 Introduction

2 EGCC and AEDC

3 Criterion of modifying the column stage number

4 Calculation procedure

5 Conclusions

Optimization of Complex Column Networks with Hybrid Genetic Algorithm

1 Introduction

2 Methodology

3 Case Study

4 Conclusions

Using PSE to develop innovative cryogenic air separation processes

1 Introduction

2 An innovative vapor recompression air distillation scheme

3 Plant performance comparison

4 Conclusion

Heterogeneous batch distillation with variable decanter hold-up

1 Introduction

2 Model description

3 Operational policies

4 Rigorous simulation results

5 Conclusions

Economic NMPC for energy intensive applications with electricity price prediction

1 Introduction

2 Economically-oriented NMPC formulation

3 Volatile electricity pricing schemes

4 Simulation results

5 Conclusion

A Multivariable Nonlinear Model Predictive Control Framework for a PEM Fuel Cell System

1 Introduction

2 Experimental Unit Setup and Automation System

3 Nonlinear Model Predictive Control Framework

4 Results and Discussion

5 Conclusions

Online Model Predictive Control of Municipal Water Distribution Networks

1 Introduction

2 Modelling Water Distribution Networks

3 Control Problem Description

4 Demonstration

5 Conclusions

Multi-fidelity models for model predictive control

1 Introduction

2 Analysis of the effect of using multi-fidelity models in optimal control

3 Example

4 Conclusion

A Frequency Domain Approach for MPC Tuning

1 Introduction

2 Frequency Domain Interpretation of MPC Tuning

3 MPC Tuning Method

4 Conclusion

Control Strategy for Thermal Budget and Temperature Uniformity in Spike Rapid Thermal Processing Systems

1 Introduction

2 RTP System

3 Thermal Budget Control

4 Simulation Results

5 Conclusions

Systematic Formalization of Control Requirements using Hierarchical Cause-Effect Charts1

1 Introduction

2 The Formalization Procedure

3 Formal Specification

4 Conclusions

Self-optimizing control for hydrogen optimization in a diesel hydrodesulfurization plant

1 Introduction

2 Hydrodesulfurization plant description

3 Self-optimizing control structure

4 Discussion

Reconfigurable stabilizing control applied to a neutralization process

1 Introduction

2 Neutralization Process

3 Control Reconfiguration Procedure

4 Simulation Results

5 Conclusions

Robust IMC-PID Design for Optimal Closed-loop Response with Specified Gain and Phase Margins for SOPTD Systems

1 Introduction

2 System Frequency Analysis

3 IMC-PID Design Based on Gain and Phase Margins

4 Simulation Examples

5 Conclusion

A New Strategy of Locality Enhancement for Justin-Time Learning Method

1 Introduction

2 Conventional Just-in-Time Learning Techniques

3 Locality-enhanced Just-in-Time Learning

4 Case Study: van de Vusse CSTR

Hybrid Dynamic Modeling of 4-CBA Hydrogenation Fixed-Bed Catalytic Reactor of PTA Production Plant

1 Introduction

2 Hybrid Modeling of PTA Hydrogenation Reactor

3 Hybrid Model

4 Results and Discussions

5 Conclusion

Abbreviations

Integrated Model-Based Support for the Design of Complex Controlled Systems

1 Introduction

2 The Pipeless Plant

3 **The** *Design Framework*

4 Model-based Design of the Pipeless Plant

5 Conclusions and Future Work

Design and modeling of a new periodical-steady state process for the oxidation of sulfur dioxide in the context of an emission free sulfuric acid plant

1 Introduction

2 Emission free sulfuric acid process

3 Model and numerical methods

4 Experimental set up and process synthesis

5 Results and discussion

6 Acknowledgement

Thinking Ontologies

1 Structure is the Key

2 Ontologies are models

3 Discussion

The impact of radiation on gas combustion modeling for a Kraft recovery boiler

1 Introduction

2 Methods

3 Simulation

4 Results

5 Conclusions

Process development in a miniplant scale - A multilevel - multiscale PSE approach for developing an improved Oxidative Coupling of Methane process

1 Introduction

2 Catalyst selection - laboratory scale

3 Reactor concepts - mini-plant scale

4 Downstream concept - miniplant scale

5 Conclusion

6 Acknowledgment

Phenomena-based Process Synthesis and Design to achieve Process Intensification

1 Introduction

2 Methodology

3 Case study

Conclusions

Three-layer solution strategy for multi-objective process synthesis

1 Introduction

2 Three-layer Solution Strategy

3 Case Study

4 Conclusions

Conceptual process synthesis for isolation and purification of natural products from plants - A case study of artemisinin from Artemisia annua

1 Introduction

2 The methodology

3 Case study of artemisinin from *Artemisia annua*

4.Conclusion

Synthesis and Optimization of Distributed Energy Supply Systems using Automated Superstructure and Model Generation

1 Introduction

2 Automated superstructure and model generation

3 Case study: Retrofit extension of an industrial site

4 Summary and conclusions

Design of optimal disease and patient-specific chemotherapy protocols for the treatment of Acute Myeloid Leukaemia (AML)

1 Framework for the design of optimal disease and patient-specific chemotherapy protocols

2 Mathematical Modeling

3 Patient case study

4 Concluding Remark

A Control Engineering Perspective of Calcium Homeostasis

1 Introduction

2 Model Development

3 Results and Discussion

4 Conclusions

Hemodynamics of cerebral micro vasculature

1 Introduction

2 Methods

3 Results

4 Discussion and Conclusions

Medical Image-based Systematic Design of Human Gene Silencing Therapies

1 Introduction

2 Methodology

3 Results and Discussion

4 Conclusions

Author Index