Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease, 1st Edition

Part II: Translational and Clinical Research

Recent Advances in Parkinsons Disease, 1st Edition,Anders Bjorklund,Angela Cenci-Nilsson,ISBN9780444537508

Progress in Brain Research

Bjorklund   &   Cenci-Nilsson   

Elsevier Science




235 X 191

Presents Parkinson’s disease as a topic for basic, translational, and clinical investigation

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Key Features

  • Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist


This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.


Neuroscientists, psychologists, neurologists

Anders Bjorklund

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients

Affiliations and Expertise

Lund University, Lund, Sweden

View additional works by Anders Bjorklund
Information about this author is currently not available.

Recent Advances in Parkinsons Disease, 1st Edition

Section I: Animal models of PD

  1. What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
  2. Neurotoxic in vivo models of Parkinson’s disease: recent advances - Timothy Greenamyre & Jason R. Cannon
  3. Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson’s disease - Stephen B. Dunnett & Mariah Lelos
  4. Genetic mouse models of Parkinson’s disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
  5. Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson’s disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
  6. Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
  7. The MPTP-lesioned non-human primate models of Parkinson’s disease. Past, present and future - Susan Fox & Jonathan Brotchie
  8. Section II: Exploring PD with brain imaging

  9. Abnormal Metabolic Brain Networks in Parkinson’s Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
  10. Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
  11. Brain imaging after neural transplantation - Paola Piccini & Marios Politis
  12. Imaging non-motor aspects of Parkinson’s disease - David Brooks & Nicola Pavese
  13. Section III: Frontiers in PD treatment

  14. Gene therapy for dopamine replacement - Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll
  15. Neurotrophic Factor Therapy for Parkinson’s disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
  16. Neural grafting in Parkinson’s disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar
  17. Neural grafting in Parkinson´s disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Björklund, Stephen B Dunnett, Christian Winkler
  18. Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce
  19. The challenge of Non-Motor Symptoms in Parkinson´s Disease - Ray Chaudhuri & Per Odin

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