Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease, 1st Edition

Part I: Basic Research

Recent Advances in Parkinsons Disease, 1st Edition,Anders Bjorklund,Angela Cenci-Nilsson,ISBN9780444536143

Progress in Brain Research

Bjorklund   &   Cenci-Nilsson   





235 X 191

Presents Parkinson’s disease as a topic for basic, translational, and clinical investigation

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Key Features

Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research.
All chapters include comprehensive background information and are written in a clear form that is accessible also to the non-specialist.


This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.


Neuroscientists, psychologists, neurologists

Anders Bjorklund

As a neuroanatomist and developmental neurobiologist, during the 1970s Björklund’s lab originated reliable methods for transplantation of embryonic tissues into brain that pioneered practical cell transplantation in the central nervous system, providing the basis for technologies that are now used by laboratories world-wide. In parallel, work in the field has progressed from basic anatomical and developmental studies in experimental animals, via applications for assessing cell replacement and repair using primary and stem cells in the damaged brain, and now underpinning the majority of methods in development for cell therapy in patients. His laboratory continues to analyse the fundamental neurobiology and principles of cell transplantation, regeneration and integration in the CNS, as well as originating the first trials of effective clinical cell transplantation (for Parkinson’s disease) in patients

Affiliations and Expertise

Lund University, Lund, Sweden

View additional works by Anders Bjorklund
Information about this author is currently not available.

Recent Advances in Parkinsons Disease, 1st Edition

Section I: Genetic and molecular mechanisms of neurodegeneration in PD


Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects

Thomas Gasser


The impact of genetic research on our understanding of Parkinson's Disease

Ted Dawson

Ian Martin, Valina L. Dawson


Unraveling the role of defective genes

Mark Cookson


What causes the death of dopaminergic neurons in Parkinson’s disease?

James Surmeier

Jaime N. Guzman, Javier Sanchez-Padilla and Joshua Goldberg


Intracellular Signaling Pathways In Dopamine Cell Death And Axonal Degeneration

Robert Burke


Control of mitochondrial integrity in Parkinson’s Disease

Serge Przedborski

Cristofol Vives-Bauza, Maja Tocilescu, Rosa L. A. deVries, Dana M. Alessi, Vernice Jackson-Lewis


Role of Post-Translational Modifications in Modulating the Structure, Function and Toxicity of a-synuclein: Implications for Parkinson’s Disease Pathogenesis and Therapies

Hilal Lashuel

Abid Oueslati, Margot Fournier

Section II: Cellular and system-level pathophysiology of the basal ganglia in PD


The role of dopamine in modulating the structure and function of striatal circuits

James Surmeier

Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian and Joshua L. Plotkin


Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson’s disease

Monica Di Luca

Paolo Calabresi


Adenosine-dopamine interactions

Micaela Morelli

Anna R Carta, Anil Kachroo, Michael A. Schwarzschild


Maladaptive plasticity in L-DOPA-induced dyskinesia

M. Angela Cenci

Christine Konradi


Effects of GPi and STN inactivation on physiological, motor, cognitive

and motivational processes in animal models of Parkinson's disease

Chistelle Baunez

Paolo Gubellini


Computational physiology of the basal ganglia in Parkinson’s disease

Hagai Bergman

Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer


Neurocomputational models of motor and cognitive

deficits in Parkinson's Disease

Michael J. Frank

Thomas V. Wiecki

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