Brain Stimulation

Brain Stimulation, 1st Edition

Handbook of Clinical Neurology (Series editors: Aminoff, Boller, Swaab)

Brain Stimulation, 1st Edition,Andres Lozano,Mark Hallett,ISBN9780444534972






262 X 192

A comprehensive tutorial-reference focused on brain stimulation, including deep brain stimulation and other noninvasive methods for clinical application

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Key Features

  • A comprehensive introduction and overview of deep brain stimulation (DBS)
  • Coverage of DBS, transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS)
  • Details the basic science and research utility of DBS and clinical application


The field of brain stimulation is expanding rapidly, with techniques such as DBS, TMS, and tDCS moving from the research community into clinical diagnosis and treatment. Clinical applications include treating disorders such as Parkinson's disease, dystonia, and even depression.

The chapters of Brain Stimulation are written by leading international researchers and clinical specialists include coverage of techniques, modes of action and applications in physiology and therapeutics. The combination of research and clinical coverage will be of interest to neurologists, neurosurgeons, psychiatrists, neuroscientists, and health care workers.


Neurologists, Neuroscience research workers

Andres Lozano

Affiliations and Expertise

Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Canada

Mark Hallett

Affiliations and Expertise

School of Medicine and Health Sciences, George Washington University, Washington, DC, USA

Brain Stimulation, 1st Edition

SECTION 1  Deep brain stimulation

Basic science

1. Principles of electrical stimulation of neural tissue
    David T. Brocker and Warren M. Grill (Durham, USA)

2. Deep brain stimulation in animal models
    Yasin Temel (Maastricht, the Netherlands)

3. Deep brain stimulation surgical techniques
     Fahd R. Khan and Jaimie Henderson (Stanford, USA)

4. Deep brain stimulation: how does it work ?
     Filippo Agnesi, Matthew D. Johnson and Jerrold L. Vitek (Minneapolis, USA)

5. Computational modelling of deep brain stimulation
     Cameron C. McIntyre and Thomas J. Foutz (Cleveland, USA)

6. Therapeutic stimulation versus ablation
     Marwan I. Hariz and Gun-Marie Hariz (London, UK and Umeå, Sweden)

7. Magnetic resonance imaging safety of deep brain stimulator devices
     Chima O. Oluigbo and Ali R. Rezai (Columbus, USA)

8. Brain stimulation and functional imaging with fMRI and PET
     Ji Hyun Ko, Christopher C. Tang and David Eidelberg
    (Manhasset, USA)

Clinical applications of deep brain stimulation

9. Deep brain stimulation for Parkinson disease: patient selection
     Pierre Pollak (Geneva, Switzerland)

10. Deep brain stimulation for Parkinson disease: clinical outcome
       Guenther Deuschl (Kiel, Germany)

11. Postoperative management of deep brain stimulation in Parkinson disease
       Anna Castrioto, Jens Volkmann and Paul Krack (Grenoble, France and Würzburg,

12. Psychiatric considerations in deep brain stimulation for Parkinson disease
       Valerie Voon, Nicholas Araki Howell and Paul Krack (Cambridge, UK and Grenoble,

13. Deep brain stimulation for essential tremor
       Jules M. Nazzaro, Kelly E. Lyons and Rajesh Pahwa (Kansas City, USA)

14. Deep brain stimulation for dystonia
       Marie Vidailhet, Marie-France Jutras, Emmanuel Roze and David Grabli (Paris,

15. The role of deep brain stimulation in the treatment of secondary dystono-dyskinesia
       Christian Saleh, Victoria Gonzalez and Philippe Coubes (Montpellier, France)

16. Deep brain stimulation for other tremors, myoclonus and chorea
       Philip Starr, (San Francisco, USA)

17. Deep brain stimulation for epilepsy
       Robert S. Fisher (Stanford, USA)

18. Deep brain stimulation for major depression
       Thomas E. Schlaepfer and Bettina H. Bewernick (Bonn, Germany and Baltimore, USA)

19. Deep brain stimulation in obsessive-compulsive disorder: neurocircuitry and clinical
      Nir Lipsman, Peter Giacobbe and Andres M. Lozano (Toronto, Canada)

20. Deep brain stimulation in Tourette syndrome
       Veerle  Visser-Vandewalle and Jens Kuhn (Maastricht, the Netherlands and Cologne,

21. Deep brain stimulation in addiction due to psychoactive substance use
       Jens Kuhn, Christian P. Bührle, Doris Lenartz and Volker Sturm (Cologne, Germany)

22. Evaluating the potential of deep brain stimulation for treatment-resistant anorexia nervosa
       Nir Lipsman, Blake Woodside and Andres M. Lozano (Toronto, Canada)

23. Deep brain stimulation for pain
       Erlick A.C. Pereira, Alexander L. Green and Tipu Z Aziz (Oxford, UK)

24. Central thalamic deep brain stimulation for support of forebrain arousal regulation in the
      minimally conscious state
       Nicholas D. Schiff (New York, USA)

25. Deep brain stimulation for cognitive disorders
       Adrian W. Laxton, Nir Lipsman and Andres M. Lozano (Toronto, Canada and Winston-
       Salem, USA)

26. Ethics guidance for neurological and psychiatric deep brain stimulation
       Emily Bell and Eric Racine (Montréal, Canada)

SECTION 2  Superficial brain stimulation

Basic principles

27. Transcranial electric and magnetic stimulation: technique and paradigms
       Walter Paulus, Angel V. Peterchev and Michael Ridding (Gottingen, Germany; Durham,
       USA and Adelaide, Australia)

28. Epidural and subdural stimulation
       Volker Tronnier and Dirk Rasche (Lübeck, Germany)

29. Physics of effects
       Pedro Cavaleiro Miranda (Lisbon, Portugal)

30. Biology of effects
       Vincenzo Di Lazzaro (Rome, Italy)

Clinical utility in diagnosis

31. Central motor conduction time
       Kaviraja Udupa and Robert Chen (Toronto, Canada)

32. Pharmaco-TMS studies of motor excitability
       Ulf Ziemann (Frankfurt am Main, Germany)

Therapeutic uses

33. Treating the depressions with superficial brain stimulation methods
       Mark S. George, Joseph J. Taylor and Baron Short (Charleston, USA)

34. Other therapeutic psychiatric uses of superficial brain stimulation
       Mario A. Cristancho, Pilar Cristancho and John P. O’Reardon (Philadelphia, St Louis
       and Stratford, USA)

35. Pain
       Jean-Pascal Lefaucheur (Créteil, France)

36. Tinnitus
       Berthold Langguth and Dirk De Ridder (Regensburg, Germany and Antwerp, Belgium)

37. Parkinson disease
       David H. Benninger (Lausanne, Switzerland)

38. Dystonia
       Ryuji Kaji (Tokushima, Japan)

39. Epilepsy
       Alexander Rotenberg (Boston, USA)

40. Non-invasive brain stimulation in neurorehabilitation
       Marco Sandrini and Leonardo G. Cohen (Bethesda, USA)

Research applications

41. Plasticity
       Joseph Classen (Leipzig, Germany)

42. Research applications of non-invasive superficial brain stimulation in Parkinson disease
       John C. Rothwell and Mark J. Edwards (London, UK)

43. Transcranial magnetic stimulation in dystonia
       Angelo Quartarone (Messina, Italy and New York, USA)

44. Non-invasive brain stimulation in Huntington disease
       Alfredo Berardelli and Antonio Suppa (Rome, Italy)

45. Utility of transcranial magnetic stimulation in delineating ALS pathophysiology
       Steven Vucic and Matthew C. Kiernan (Sydney, Australia)

46. Superficial brain stimulation in multiple sclerosis
       Regina Schlaeger (Basel, Switzerland)

47. Brain stimulation in migraine
       Filippo Brighina, Giuseppe Cosentino and Brigida Fierro (Palermo, Italy)

48. Dementia
       Raffaele Nardone, Stefan Golaszewski and Eugen Trinka (Salzburg, Austria and
       Merano, Italy)

49. Addiction
       Jodie Feil and Abraham Zangen (Clayton, Australia and Beer-Sheva, Israel)

50. Tourette syndrome
       Shahana Nasrin and Donald L. Gilbert (Cincinnati USA)

51. Cerebellum
       Stefan Jun Groiss and Yoshikazu Ugawa (Fukushima, Japan)

52. Transcranial magnetic stimulation and vision
       Juha Silvanto (Espoo and Helsinki, Finland)

53. Transcranial magnetic stimulation techniques to study the somatosensory system: 
      research applications
       W. Richard Staines and David A.E. Bolton (Waterloo, Canada)

54. Language
      Luigi Cattaneo (Mattarello, Italy)

55. Research applications of noninvasive brain stimulation: learning and memory
       Anna-Katharine Brem, Kathy Ran and Alvaro Pascual-Leone (Boston, USA and
       Barcelona, Spain)

56. Cognition
       Carlo Miniussi and Manuela Ruzzoli (Brescia, Italy and Barcelona, Spain)

Quotes and reviews

"This outstanding and comprehensive new book covers the rapidly growing use of deep brain stimulation (DBS) as well as superficial brain stimulation (SBS) for the treatment of neurological and psychiatric disorders…This is a first-rate book covering the emerging treatment technology of DBS and SBS. Any clinician who wants to keep abreast of these important treatment modalities should read this book. I highly recommend it." Rating: 3 Stars--Doody.com, March 21, 2014
"This volume is focused on brain stimulation, considering both deep and superficial versions. Among the topics are postoperative management of deep brain stimulation in Parkinson's disease, evaluating the potential of deep brain stimulation for treatment-resistant anorexia nervosa, treating depression with superficial brain stimulation methods, noninvasive brain stimulation in neuro-rehabilitation…"--ProtoView.com, January 2014

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