Cardiovascular Development

Cardiovascular Development, 1st Edition

Cardiovascular Development, 1st Edition,Paul Wassarman,Rolf Bodmer,ISBN9780444530141

Wassarman   &   Bodmer   

Elsevier Science




229 X 152

The latest technological advancements in understanding the development of cardiovascular systems

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Key Features

* Ties together the development of heart morphology and conduction system
* The latest developments in vertebrate and invertebrate genetic model systems
* Technological advancements in cardiovascular science


In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms.

Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.


Developmental biologists, cardiologists

Paul Wassarman

Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.

Affiliations and Expertise

Icahn School of Medicine at Mount Sinai, USA

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Cardiovascular Development, 1st Edition

1. Heart Development in Drosophila
Li Qian, Jiandong Liu and Rolf Bodmer

2. Morphogenesis of the Vertebrate Heart
W.M.H. Hoogaars, V.M. Christoffels, and A.F.M. Moorman

3. Heart Development and T-box Transcription Factors: Lessons from Avian Embryos
Elaine L. Shelton and Katherine E. Yutzey

4. Transcriptional Control of Cardiac Boundary Formation
Anabel Rojas and Brian L. Black

5. Signaling Pathways in Embryonic Heart Induction
Rosa M. Guzzo, Ann C. Foley, Yessenia M. Ibarra and Mark Mercola

6. Islet1 Progenitors in Developing and Postnatal Heart
Sylvia Evans

7. Role of MicroRNAs in Cardiovascular Biology
Eva Sama and Deepak Srivastava

8. Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in Left-Right Development
Judith M. Neugebauer and H. Joseph Yost

9. Development of the conduction system: Picking up the pace
Dina Myers Stroud and Gregory E. Morley

10. Transcriptional Control of the Cardiac Conduction System
Shan-shan Zhang and Benoit G. Bruneau

11. Genetic dissection of hematopoiesis using Drosophila as a model system
Cory J. Evans, Sergey A. Sinenko, Lolitika Mandal, Julian A. Martinez-Agosto, Volker Hartenstein and Utpal Banerjee

12. Vascular Development in the Zebrafish
Josette Ungos and Brant M. Weinstein

13. Development and function of the epicardium
Jörg Manner and Pilar Ruiz-Lozano

14. Genetics of transcription factor mutations
Vijaya Ramachandran and Woodrow Benson

15. Human genetics of congenital heart disease
Jeff Towbin
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