Key Features
* Ties together the development of heart morphology and conduction system
* The latest developments in vertebrate and invertebrate genetic model systems
* Technological advancements in cardiovascular science
Description
In 1993, Rolf Bodmer described a gene he named tinman that was required for the formation of the dorsal aorta of the fly. Flies without a functional tinman gene had no heart. Quickly, mammalian counterparts of the tinman gene were identified and found to be expressed by early cardiomyogenic precursors and by cardiomyocytes throughout heart development. Since then, significant progress has been made in the understanding of molecular and genetic determinants of heart formation. An ever growing number of genes have been identified that are required for cardiogenesis, as evidenced by severe abnormalities in cardiac development produced by inactivation in the mouse or inhibition of gene function in other model organisms.
Cardiovascular Development covers some of the latest research in the study of heart formation. Volume Editor Rolf Bodmer has assembled a world-class list of contributors whose research uses a variety of animal models and whose findings are certain to enhance our understanding of this exciting field.
Readership
Developmental biologists, cardiologists
Cardiovascular Development, 1st Edition
1. Heart Development in Drosophila
Li Qian, Jiandong Liu and Rolf Bodmer
2. Morphogenesis of the Vertebrate Heart
W.M.H. Hoogaars, V.M. Christoffels, and A.F.M. Moorman
3. Heart Development and T-box Transcription Factors: Lessons from Avian Embryos
Elaine L. Shelton and Katherine E. Yutzey
4. Transcriptional Control of Cardiac Boundary Formation
Anabel Rojas and Brian L. Black
5. Signaling Pathways in Embryonic Heart Induction
Rosa M. Guzzo, Ann C. Foley, Yessenia M. Ibarra and Mark Mercola
6. Islet1 Progenitors in Developing and Postnatal Heart
Sylvia Evans
7. Role of MicroRNAs in Cardiovascular Biology
Eva Sama and Deepak Srivastava
8. Divergent Roles of Hedgehog and Fibroblast Growth Factor Signaling in Left-Right Development
Judith M. Neugebauer and H. Joseph Yost
9. Development of the conduction system: Picking up the pace
Dina Myers Stroud and Gregory E. Morley
10. Transcriptional Control of the Cardiac Conduction System
Shan-shan Zhang and Benoit G. Bruneau
11. Genetic dissection of hematopoiesis using Drosophila as a model system
Cory J. Evans, Sergey A. Sinenko, Lolitika Mandal, Julian A. Martinez-Agosto, Volker Hartenstein and Utpal Banerjee
12. Vascular Development in the Zebrafish
Josette Ungos and Brant M. Weinstein
13. Development and function of the epicardium
Jörg Manner and Pilar Ruiz-Lozano
14. Genetics of transcription factor mutations
Vijaya Ramachandran and Woodrow Benson
15. Human genetics of congenital heart disease
Jeff Towbin
