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Epilepsy, Part II: Treatment
 
 

Epilepsy, Part II: Treatment, 1st Edition

 
Epilepsy, Part II: Treatment, 1st Edition,Hermann Stefan,William Theodore,ISBN9780444528995
 
 
 

Stefan   &   Theodore   

Elsevier

9780444528995

9780444535061

608

262 X 192

A comprehensive and detailed overview of the treatment for epilepsy.

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Key Features

*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Description

Epilepsy, Part II, Treatment, Volume 108, provides a full description of epilepsy pathology and etiology, antiepileptic drug treatment, the approach to surgical evaluation and alternative procedures to be considered, in both children and adults, as well as brain stimulation and diet treatment. Economic and psychosocial issues such as stigma are fully covered. The special problems of epilepsy treatment in the developing world are described. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, establishes the scientific and practical diagnosis of epilepsy. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

Readership

Clinical neurologists and research neuroscientists

Hermann Stefan

Affiliations and Expertise

Director of Epilepsy Centre, Neurological Clinic, University Hospital, Erlangen, Germany

William Theodore

Affiliations and Expertise

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, and Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Epilepsy, Part II: Treatment, 1st Edition

Series page

Handbook of Clinical Neurology 3RD Series

Foreword

Preface

Contributors

Chapter 30 Metabolic and degenerative disorders

Introduction

Epilepsy features in metabolic and degenerative disorders

Progressive myoclonic epilepsies

Metabolic diseases more frequently associated with epilepsy

Metabolic disease amenable to specific treatment

Conclusion

Chapter 31 Neurocutaneous syndromes

Introduction

Neurofibromatosis type 1

Neurofibromatosis type 2

Tuberous sclerosis

Sturge-weber syndrome

Incontinentia pigmenti (bloch-sulzberger disease)

Hypomelanosis of ito: incontinentia pigmenti achromians

Ataxia-telangiectasia

Rare neurocutaneous diseases

Conclusion

Chapter 32 Cortical malformations

Introduction

Principles of cortical development

Classification systems

Different types of malformations of cortical development

Conclusions

Chapter 33 Epilepsy-associated brain tumors

Introduction

Neuropathological classification of epilepsy-associated tumors

Tumors and epileptogenesis

Future research strategies

Chapter 34 Seizures after stroke

Introduction

Definitions and methodological issues

Epidemiology of seizures after stroke

Risk factors for poststroke seizures

Risk factors for poststroke epilepsy

Do seizures influence stroke outcome?

Mechanisms of seizures after stroke

Diagnostic procedures

Management

Conclusion

Chapter 35 Posttraumatic epilepsy

Introduction

Historical background

Etiology

Risk factors

Imaging

Latency

Natural history

Age and development of epilepsy

Pathology

Prevention, prophylaxis, and neuroprotection

Epileptogenesis

Chapter 36 Infection and inflammation

Introduction

Parasitic infections

Bacterial infections

Viral infections

Fungal infections

Noninfectious inflammatory disorders

Chapter 37 Hippocampal sclerosis

Historical background

Pathological diagnosis

Pathogenesis

Clinical diagnosis

Epidemiology

Clinical features

Natural course

Electroclinical features

Electrophysiological investigations

Functional studies

Outcome

Chapter 38 Natural course of epilepsies

Natural course of untreated epilepsies

Natural course of treated epilepsies

Concluding remarks

Chapter 39 Mechanisms of action of antiseizure drugs

Introduction

Classifying antiseizure drugs by mechanism of action

Drugs discovered and marketed before 1990

Drugs discovered and marketed after 1990

Chapter 40 Principles of drug treatment in adults

Introduction

Objectives of treatment

Indications for treatment and when to start

Selection of drugs in the general adult population

Strategies and drug selection in special populations

How to start

Individualization of dosage

Monitoring treatment

If the first treatment fails

Discontinuation of treatment

Chapter 41 Principles of drug treatment in children

Initial approach to the pediatric patient and workup

Deciding to treat or not to treat

Choice of antiepileptic drug for initial monotherapy

Initiation of antiepileptic drug therapy and of follow-up

Decisions about substitution and add-on therapy

Current indications and evidence on the effectiveness and tolerability of specific antiepileptic drugs

Approach to intractable patients and consideration of epilepsy surgery

Discontinuation of therapy

Conclusions, implications for practice, future research

Chapter 42 Antiepileptic drugs

Introduction

Advantages of current antiepileptic drug treatment

Limitations of current drug treatment

Efficacy concerns

Advantages and disadvantages of individual antiepileptic drugs

Advantages and disadvantages of antiepileptic drugs by age group

Conclusion

Chapter 43 Pharmacoresistance

Introduction

Clinical patterns of drug resistance

Comparative clinical trials

Antiepileptic drugs

Predictive factors

Mechanisms of pharmacoresistance

Target hypothesis

Transporter hypothesis

Strategies to determine resistance mechanisms in individual patients

Pharmacogenetic analysis

Brain imaging techniques

Strategies to overcome putative resistance mechanisms

Chapter 44 Gender issues

Introduction

Animal studies

Human studies

Treatment

Sexuality

Sexual function

The effects of antiepileptic drugs on sperm

Management of pregnancy and birth

Conclusion

Chapter 45 Ketogenic diet

Introduction

Mechanism of action

Patient selection

Diet initiation

Efficacy and side-effects

Other anticonvulsant diets

Prognosis

Future directions

Chapter 46 Status epilepticus in children

Introduction

Definition

Incidence

Seizure type

Etiology

Risk factors for status epilepticus

Evaluation

Management

Morbidity and mortality

Long-term sequelae of afebrile status epilepticus in childhood

Sequelae of febrile status epilepticus

Conclusion

Acknowledgments

Chapter 47 Status epilepticus in adults

Introduction

Definition

Classification

Epidemiology

Treatment

New options

Future options

Chapter 48 Who is a surgical candidate?

Introduction

Historical Review

The Concept of Surgically Remediable Epilepsy Syndromes

Selection of Surgical Candidates

The Patient’s Perspective about Surgical Candidacy

Who Should be Referred to an Epilepsy Surgery Center?

Chapter 49 Preoperative evaluation in children for epilepsy surgery

Introduction

Ictal semiology

Electroencephalography

Magnetoencephalography

Invasive recording

Functional cortical mapping

Neuroimaging

Single photon emission computed tomography

Positron emission tomography

Functional MRI

Optical imaging

Neuropsychology

Expectations

Chapter 50 Presurgical evaluation in adults: noninvasive

Introduction

Intensive video-eeg monitoring

Magnetic resonance imaging

Neuropsychological testing

Single photon emission computed tomography and positron emission tomography

Functional magnetic resonance imaging

Magnetoencephalography

Proton magnetic resonance spectroscopy

Wada test

Conclusions

Chapter 51 Invasive evaluation

Introduction

Historical overview

Invasive recordings: for whom?

Invasive recordings: how?

Invasive recordings: definition of the ictal onset zone

Conclusion

Chapter 52 Epilepsy neurosurgery in children

Introduction

What makes surgical treatment of epilepsy in children different?

Identification and prediction of treatment-resistant epilepsy in children

When to refer pharmacoresistant children for comprehensive epilepsy evaluation

The importance of early seizure control for the developing human brain

Epidemiology of pharmacoresistance and surgery in children

Clinical characteristics of pediatric epilepsy surgery patients

Presurgical evaluations for children with treatment-resistant epilepsy

Perioperative considerations and surgical approaches

Outcomes after epilepsy neurosurgery in children

Summary and future directions

Acknowledgment

Chapter 53 Surgery in adults

The role of temporal resections in the epilepsy surgery spectrum

Temporal resections: present practice and techniques

Outlook and conclusion

Conclusion

Chapter 54 Lateral extratemporal resections in adults

Screening and noninvasive analysis

Invasive analysis

Multiple subpial transections

Resective surgery

Outcome

Chapter 55 Surgical management of medial extratemporal epilepsy

Introduction

Evaluation

Invasive evaluation

Surgical techniques

Conclusion

Chapter 56 Epilepsy treatment in developing countries

Introduction

General considerations of generic drugs

Generic antiepileptic drugs in developing countries

Normative for the use of generic medication

Final remarks

Chapter 57 Epilepsy surgery in developing countries

Introduction

Epilepsy surgery: differences between developed and developing countries

Are surgical results different in developing countries and developed countries?

Solutions or alternative ways for developing countries

Conclusions

Chapter 58 Neurostimulation for epilepsy

Introduction

Vagus nerve stimulation

Deep brain stimulation

Conclusion

Chapter 59 Innovative treatments for epilepsy

Introduction

Radiosurgery

Local delivery for epilepsy

Conclusion

Chapter 60 Social aspects of epilepsy and rehabilitation

Introduction

Methodological approach

Assessment of seizure severity

Social participation and barriers

Examples of interventions

Rehabilitation

Conclusion

Chapter 61 Economic aspects of epilepsy

Introduction

Cost of illness studies

Cost-effectiveness of new treatments

Future research

Index

 
 
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