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Epilepsy, Part I: Basic Principles and Diagnosis
 
 

Epilepsy, Part I: Basic Principles and Diagnosis, 1st Edition

 
Epilepsy, Part I: Basic Principles and Diagnosis, 1st Edition,Hermann Stefan,William Theodore,ISBN9780444528988
 
 
 

Stefan   &   Theodore   

Elsevier

9780444528988

9780444535054

548

262 X 192

A comprehensive and detailed overview of the basic principles and diagnosis of epilepsy.

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Key Features

*A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
*International list of contributors including the leading workers in the field.
*Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.

Description

Epilepsy, Part I, Basic Principles and Diagnosis, Volume 107, in the Handbook of Clinical Neurology series offers a comprehensive review of our knowledge of the field today, including epidemiology, basic mechanisms, animal models, and topics of increasing interest such as the role of inflammation in epilepsy. It provides a comprehensive approach to description of the clinical, electrographic and imaging aspects of the epilepsies, with a clear outline of contemporary classification and the role of modern diagnostic techniques, as well as neuropsychological and psychiatric aspects of epilepsy. Chapters are authored by internationally respected neurologists with varied perspectives insuring depth to the content. Epilepsy, Part II, Treatment, Volume 108, continues coverage of epilepsy with a focus on treatment. The volumes will be a very important resource for basic scientists, clinical investigators, and all health professionals treating patients with epilepsy.

Readership

Clinical neurologists and research neuroscientists

Hermann Stefan

Affiliations and Expertise

Director of Epilepsy Centre, Neurological Clinic, University Hospital, Erlangen, Germany

William Theodore

Affiliations and Expertise

Clinical Epilepsy Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, and Uniformed Services University of the Health Sciences, Bethesda, MD, USA

Epilepsy, Part I: Basic Principles and Diagnosis, 1st Edition

Series Page

Handbook of Clinical Neurology 3rd Series

Foreword

Preface

Contributors

Chapter 1 Molecular basis of acquired epileptogenesis

Introduction

Which genes are altered at different phases of epileptic process and what is their function?

Conclusion

Chapter 2 Cellular bases of focal and generalized epilepsies

Introduction

Intrinsic properties of neurons

Synaptic properties of neurons

Modulation of neuronal excitability

Pathological processes

Concluding comment

Chapter 3 Epilepsy as a dynamic disease of neuronal networks

Introduction

How may the stability of neuronal networks be maintained and disturbed in epilepsy?

How may transitions between normal and epileptic behavior occur in thalamocortical networks?

How may transitions between normal and epileptic behavior occur in neuronal networks of the hippocampal system?

How may neuronal networks involved in epileptic behavior be identified and analyzed in a clinical setting?

Conclusion: general concepts and models

Chapter 4 Animal models

Introduction

In vitro models

In vivo animal models

Determination of seizure susceptibility

Models

Syndromes or encephalopathies (not genetically induced)

Genetic models

Summary

Chapter 5 Classification of epilepsies and seizures: historical perspective and future directions

Introduction

Generalized versus focal: a nondichotomy?

Terms and concepts for grouping etiology

Abandoning the rigid structure of the 1989 classification

Chapter 6 The epidemiology of the epilepsies

Introduction

Definitions

Incidence studies

Prevalence

Risk factors for epilepsy

Prognosis

Mortality

Conclusion

Chapter 7 Maturation of the human brain and epilepsy

Introduction

Developmental changes in brain morphology

Developmental changes in myelination

Behavioral and electroencephalographic correlates of brain development

Developmental changes in the brain physiology

Alterations in brain development as a consequence of seizures

Summary

Chapter 8 Genetics of idiopathic epilepsies

The concept of idiopathic epilepsies

The predominant pathogenetic concept: ion channel dysfunction

Non-ion channel genes in idiopathic epilepsy

Chapter 9 The genetics of focal epilepsies

Introduction

Autosomal dominant nocturnal frontal lobe epilepsy

Familial temporal lobe epilepsy

Familial partial epilepsy with variable foci

Benign childhood epilepsies

Polygenic epilepsies

Neuronal migration disorders

Chapter 10 Inflammation and epilepsy

Clinical evidence

Experimental studies

Concluding remarks

Chapter 11 Age-related epileptic encephalopathies

Introduction

Infantile spasms and west syndrome

Lennox–gastaut syndrome

Landau–kleffner and continuous spike and waves during slow-wave sleep syndromes

Dravet syndrome (severe myoclonic epilepsy in infancy)

Myoclonic–astatic epilepsy

Encephalopathic childhood epilepsies associated with inherited metabolic disorders

Conclusion

Chapter 12 Epileptic syndromes with focal seizures of childhood and adolescence

Introduction

Benign focal epilepsy with centrotemporal spikes (BECTS)

Benign focal epilepsy with occipital spikes of gastaut

Benign focal epilepsy with occipital spikes of panayiotopoulos

BFEC with other lesions, BFEC variants and a typical presentations

Outlook for a unifying concept of benign focal epilepsy and benign epileptic encephalopathies of childhood: benign seizure susceptibility syndromes

Chapter 13 Idiopathic generalized epilepsies

Introduction

Epidemiology

General management of idiopathic generalized epilepsy

Genetics of idiopathic generalized epilepsy

Clinical syndromes

Conclusion

Chapter 14 Temporal lobe epilepsy

Introduction

Clinical features

Natural history

Functional anatomy of mesial temporal lobe epilepsy

Structural basis for mesial temporal lobe epilepsy: neuropathology

Summary

Chapter 15 Extratemporal epilepsies

Introduction

Frontal lobe epilepsies

Occipital lobe epilepsy

Parietal lobe epilepsy

Conclusion

Chapter 16 Reflex epilepsies

Definition and classification

Simple triggers

Complex triggers

Reflex seizures, human ictogenesis, and the nosology of the epilepsies

Widening of the concept: epilepsies with external modification of ictogenesis

Chapter 17 Psychogenic nonepileptic seizures

Definition and introduction

Epidemiology and relevance

Pathogenesis

Clinical features

Neuropsychological measures

Linguistic analysis

Diagnostic measures

Treatment

Prognosis

Conclusion

Chapter 18 Syncope

Introduction

Nomenclature, definition, and pathophysiology

Classification

Drug-induced (iatrogenic) syncope

Epidemiology

Clinical symptoms

Prognosis

Investigations

Establishing a diagnosis

Differential diagnoses

Treatment

Case examples

Discussion

Conclusion

Chapter 19 Sleep and epilepsy

Introduction

Seizure and spike propensity in relation to REM and NREM sleep stages in different epilepsies

Sleep activation in epileptic networks and syndromes

Sleep as a diagnostic tool

Chapter 20 Electroencephalography and video-electroencephalography

Introduction

Methodology of electroencephalography

Eeg in the diagnosis of epilepsy

Eeg in focal epilepsies

Eeg in generalized epilepsies

Eeg in the diagnosis of status epilepticus

Eeg in presurgical evaluation of epilepsy

Misdiagnosis of epilepsy

Quantification of epileptic seizures

Limitations of surface electroencephalography

Chapter 21 Magnetoencephalography

Introduction

Technical considerations

Applications of MEG/MSI in epilepsy

Chapter 22 Structural brain imaging

Introduction

Methodology

Major findings in MRI in patients with epilepsy

Recent improvements in imaging

Conclusion

Chapter 23 Functional magnetic resonance imaging

Introduction

EEG–fMRI

Applications in epilepsy

Brain connectivity

Conclusion

Chapter 24 Functional magnetic resonance imaging: functional mapping

Introduction

Motor and sensory mapping

Language mapping

Memory mapping

Ictal and interictal mapping

Conclusion

Chapter 25 Magnetic resonance spectroscopy in epilepsy

Introduction

Basics of magnetic resonance spectroscopy

Intracerebral metabolites detected by clinical 1h-mrs and their clinical significance

Clinical application of 1h-mrs in epilepsy

31P spectroscopy

Chapter 26 Epilepsy diagnosis

Introduction

Localization-related epilepsy

Secondary generalized epileptic syndromes

Pet in primary generalized epilepsy

Conclusion: the future of pet in epilepsy

Chapter 27 Peri-ictal single-photon emission computed tomography

Introduction

Unique role of perfusion SPECT in epilepsy

Prerequisites for conducting peri-ictal SPECT imaging

Clinical interpretation of SPECT images

SISCOM

Peri-ictal SPECT analysis with statistical parametric mapping

Peri-ictal SPECT: advantages, limitations, and precautions

Chapter 28 Clinical neuropsychology in epilepsy

Introduction

Etiology of cognitive impairments in epilepsy

Neuropsychological assessment

Neuropsychological findings in epilepsies

Differential diagnostics of neuropsychological impairment in epilepsy

Conclusion

Chapter 29 Neuropsychiatric complications of epilepsy

Introduction

Epidemiological aspects of psychiatric disorders in epilepsy

Psychiatric comorbidity as an expression of epilepsy-related activity

Why are psychiatric disorders so prevalent in epilepsy?

Clinical manifestations of common interictal psychiatric disorders: are they unique to epilepsy?

Impact of psychiatric comorbidities

Treatment of comorbid psychiatric disorders

Concluding remarks

Index

Quotes and reviews

"Stefan…and Theodore…present the first of two volumes for clinicians and neuroscientists on the clinical features and management of the neurological manifestations of epilepsy…neurologists, neuroscientists, epilepsy specialists, geneticists, and neurosurgeons from North America, Europe, Australia, and Japan address basic mechanisms;… the diagnosis of various types; …and various types of imaging. "--Reference & Research Book News, December 2013

 
 
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