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Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs, 1st Edition

Medicinal Chemistry of Anticancer Drugs, 1st Edition,Carmen Avendano,J. Carlos Menendez,ISBN9780444528247


Elsevier Science




240 X 165

A concise book that bridges the gap between elementary sources and primary literature

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Key Features

* Explains the biological basis of cancer treatment and the role of chemists in improving anticancer drugs
* Provides the historical background and serves as a comprehensive and practical guide on cancer research and anticancer drug development
* Includes coverage of different approaches to treating cancer, drug resistance, and a chapter on cancer prevention


Antitumor chemotherapy is nowadays a very active field of research, and a huge amount of information on the topic is generated every year. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book addresses the need for an updated treatment from the point of view of medicinal chemistry and drug design. The focus of Medicinal Chemistry of Anticancer Drugs is on the mechanism of action of antitumor drugs from the molecular point of view and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents, aiming at the rationalization of the action of this type of drug, which would allow the design of new active structures.


Researchers involved in oncology and pharmaceutical, medicinal and organic chemistry; Practitioners; Advanced undergraduate and graduate students in medicinal chemistry and pharmacology.

Carmen Avendano

Affiliations and Expertise

Department of Organic Chemistry, Farmaceutica, Facultad de Farmacia, Madrid, Spain

J. Carlos Menendez

Affiliations and Expertise

Department of Organic Chemistry, Farmaceutica, Facultad de Farmacia, Madrid, Spain

Medicinal Chemistry of Anticancer Drugs, 1st Edition

1. Introduction to anticancer chemotherapy

2. Antimetabolites

3. Anticancer drugs that inhibit hormone action

4. Anticancer drugs acting via radical species. Photosensitizers and photodynamic therapy of cancer.

5. DNA alkylating agents

6. Alkylating and non-alkylating compounds interacting with the DNA minor groove.

7. DNA intercalation and inhibition of topoisomerases

8. Anticancer drugs targeting tubulin and microtubules

9. Drugs targeting signaling pathways for tumour cell growth and proliferation

10.Other approaches to targeted therapy

11.Drug targeting in anticancer chemotherapy

12.Resistance to antitumour agents and drugs that modulate it

13.Cancer chemoprevention
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