Histopathology of Preclinical Toxicity Studies

Histopathology of Preclinical Toxicity Studies, 4th Edition

Interpretation and Relevance in Drug Safety Evaluation

Histopathology of Preclinical Toxicity Studies, 4th Edition,Peter Greaves,ISBN9780444538567


Academic Press




235 X 191

Filling an important gap in the pathology literature related to the preclinical safety assessment of new drugs, this book describes the pathology found in drug safety studies in laboratory animals and the relevance of these pathological findings to humans

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Key Features

  • This edition is in full color and features nearly 200 high-quality images
  • Provides extended commentary on the relevance of pathological findings and features a fully updated bibliography containing sources for further reading
  • Includes new content coverage on the commonly used transgenic animal models that are used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions


The new 4th edition of Histopathology of Preclinical Toxicity Studies is now completely in full color and continues to describe the pathology found in drug safety studies in laboratory animals with an evidence-based discussion of the relevance of these findings to the clinical investigation of new drugs for humans. Organized according to organ systems, this revision features a thoroughly updated bibliography and discusses new drug-induced pathologies and applicable species comparisons to aid in the preclinical safety assessment of new medicines. This updated reference is essential for those involved in drug safety evaluation, including pathologists, toxicologists and pharmacologists working in corporate, government, academic and research settings.


Clinical toxicologists, pathologists, and pharmacologists involved professionally in drug safety evaluation and especially those researchers working in pharmaceutical companies, contract laboratories and in government agencies

Peter Greaves

MBChB, FRCPath, Consulting Pathologist and Honorary Senior Lecturer, Department of Cancer Studies and Molecular Medicine, University of Leicester, UK

Histopathology of Preclinical Toxicity Studies, 4th Edition

Chapter 1. Introduction


Chapter 2. Integumentary System

Skin and subcutaneous tissue


Chapter 3. Mammary Gland


Chapter 4. Hemopoietic and Lymphatic Systems

Blood and bone marrow

Lymphoid system

Lymph nodes



Lymphoreticular neoplasms


Chapter 5. Musculoskeletal System



Skeletal muscle


Chapter 6. Respiratory Tract

Nose, nasal sinuses, nasopharynx and pharynx

Larynx and trachea

Bronchi and lungs


Chapter 7. Cardiovascular System

Heart and pericardium

Systemic blood vessels

Pulmonary blood vessels


Chapter 8. Digestive System

Mouth and oropharynx

Salivary glands



Stomach (glandular)

Small intestine

Large intestine


Chapter 9. Liver and Pancreas


Bile ducts, biliary system


Exocrine pancreas

Endocrine Pancreas


Chapter 10. Urinary Tract


Urinary bladder



Chapter 11. Male Genital Tract

Prostate gland

Preputial (and clitoral) glands




Chapter 12. Female Genital Tract

Clitoral glands






Chapter 13. Endocrine Glands

Pituitary gland

Adrenal gland

Thyroid gland

Parathyroid gland


Chapter 14. Nervous System and Special Sense Organs


Spinal cord, spinal nerve roots and peripheral nerves





Quotes and reviews

"There are several books on the subjects of rodent pathology, toxicologic pathology, and toxicology and several veterinary and toxicologic pathology journals but nothing like this fourth edition of Peter Greaves’s treatise. It reads like a Greaves Tox Path Wiki or perhaps a Greavipedia on preclinical histopathology and toxicology. His progressive editions since 1991 have increased in thickness and weight, adding more information and thousands of references. A Kindle edition is available with links to references in the reference lists. His experience as a physician pathologist working on drug research and development, animal toxicity, and carcinogenicity studies is clearly demonstrated in this comprehensive text…. this fourth edition can be extremely helpful if you are a veterinary or medical pathologist working with research and development and safety assessment of chemicals, particularly drugs. I highly recommend it for that audience and for toxicologists, other scientists, and regulators working with drug and other chemical safety. It is a must-have reference book in this field." --Veterinary Pathology Online

"This is an excellent and very relevant textbook for all new and practicing toxicologists and indeed, anyone involved in generating, interpreting, or reviewing toxicology data. I would thoroughly recommend having a copy." --British Toxicology Society Newsletter

"Greaves (cancer studies and molecular medicine, U. of Leicester, UK) supplies pathologists, toxicologists, and pharmacologists involved in drug- safety evaluation in corporate, government, academic, and research settings with a text on drug-induced pathology in laboratory animals and the relevance of animal findings for human patients,including comparative anatomy and pathology and drug-induced reactions in patients. Chapters are organized by body system and describe specific pathologies in them. This edition is in full color and contains updated content on the commonly used transgenic animal models used in safety assessment, specific tumor types induced by drugs in rodents, and new drug-induced pathologies and lesions. Academic Press is an imprint of Elsevier." --Reference and Research Book News, October 2012

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