Advances in Antiviral Drug Design

Advances in Antiviral Drug Design, 1st Edition

Advances in Antiviral Drug Design, 1st Edition,E. De Clercq,ISBN9780444521736

E De Clercq   

Elsevier Science




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Regularly reviewing the "state-of-the-art" developments in the antiviral drug research field, this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds. It discusses their structure-activity relationship, mechanism and targets of action, pharmacological behavior, antiviral activity spectrum, and therapeutic potential for clinical use.


Researchers, academics and postgraduates working in medical virology and infectious diseases, chemotherapy and drug discovery

E. De Clercq

Affiliations and Expertise

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium

View additional works by E. De Clercq

Advances in Antiviral Drug Design, 1st Edition

Status presens of antiviral drugs and strategies, Part I: DNA viruses and retroviruses
Status presens of antiviral drugs and strategies, Part II: RNA viruses (except retroviruses)
Methylenecyclopropane analogues of nucleosides as anti-herpes agents
Synthesis and antiviral evaluation of broad spectrum orally active analogs of cidofovir and other acyclic nucleoside phosphonates
CCR5 antagonists for the treatment of HIV infection and AIDS
The medicinal chemistry of the DATA and DAPY series of HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs)
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