Headache, 1st Edition

Handbook of Clinical Neurology Series (Editors: Aminoff, Boller and Swaab)

Headache, 1st Edition,Giuseppi Nappi,Michael Moskowitz,ISBN9780444521392





262 X 192

This volume is part of the Handbook of Clinical Neurology series, the world’s most comprehensive source of information in neurology. Now in its third generation, the series has an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology.

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Key Features

* A comprehensive guide to the advancements made in headache research and medicine, including the role of genetics and genomics
* An exhaustive accounting of cultural developments and scientific advances in headache medicine
* Critical information on primary and secondary headaches, including new therapies, prevention techniques, and management protocols


Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems. Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues. The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.

Giuseppi Nappi

Affiliations and Expertise

IRCSS Mondino, Pavia and Rome, Italy

Michael Moskowitz


Affiliations and Expertise

Professor of Neurology, Harvard-MIT Division of Health Science and Technology, Boston, MA, USA.

Headache, 1st Edition

Section 1: General aspects: 1. Epidemiology of headache. The social impact and burden of headache.

Section 2: Biological science of headache: Biological sciences related to headache. Pharmacology. Biological science of headache channels. Genetics of headaches. The neurobiology of migraine. Experimental models of migraine.

Section 3: Management of headache: Management of headache patients. Headache diaries and calendars. Implementing the International Classification of Headache Disorders, 2nd edn (ICHD-II). Triggers of migraine and tension-type headache. Acute headache in the emergency department. Therapeutic guidelines for headache. The role of prevention. Managing migraine associated with sensitization. Botulinum neurotoxin in the treatment of headache disorders. The approach to the difficult patient. Ethical issues in headache management. The role of lay associations.

Section 4: Primary headache: Migraine: Migraine: general aspects. Pathophysiology of migraine. Migraine – clinical neurophysiology. Migraine: clinical diagnostic criteria. Migraine and reproductive life. Acute treatment of migraine.

Migraine: preventive treatment.

Tension-type headache:

Tension-type headache: introduction and diagnostic criteria. Tension-type headache: mechanisms. The clinical neurophysiology of tension-type headache. Treatment of tension-type headache.

Cluster headache and trigeminal autonomic cephalalgias:

Cluster headache and trigeminal autonomic cephalalgias: general aspects. Pathophysiology of cluster headache and other trigeminal autonomic cephalalgias. Neuroimaging and clinical neurophysiology in cluster headache and trigeminal autonomic cephalalgias. Cluster headache and other trigeminal autonomic cephalalgias: diagnostic criteria. Preventive treatment of cluster headache and other trigeminal autonomic cephalalgias. Neurostimulation therapy in intractable headaches.

Other primary headache:

Other primary headache – general aspects. Primary stabbing headache. Primary cough headache, primary exertional headache, and primary headache associated with sexual activity. Hypnic headache. Primary thunderclap headache. Hemicrania continua. New daily persistent headache.

Section 5: Secondary headache:

Secondary headaches: introduction. Headache attributed to head or neck trauma. Headache attributed to stroke, TIA, intracerebral haemorrhage, or vascular malformation. Headache attributed to arteritis, cerebral venous thrombosis, and other vascular intracranial disturbances. Headache attributed to carotid or vertebral artery pain. Headache attributed to non-vascular intracranial disorder. Headache attributed to a substance or its withdrawal. Headache attributed to infections: nosography and differential diagnosis. Headache attributed to disorders of homeostasis. Headache or facial pain attributed to disorders of cranium, neck, eyes, ears, nose, sinuses, teeth, mouth, or other facial or cranial structures. Headache attributed to psychiatric disorders. Cranial neuralgias. Surgical treatment of cranial neuralgias. Central pain in the face and head.

Section 6: Special issues:

Chronobiological correlates of primary headaches. Headache: endocrinological aspects. Headache in children. Migraine vertigo (vestibular migraine). Pharmacological migraine provocation: a human model of migraine. Neuroimaging in headache. Current and emerging therapies for migraine prevention and treatment.

Quotes and reviews

"This book offers a complete overview and update of the scientific and cultural developments that, since the publication of the previous Handbook on headaches, have revolutionised understanding of migraine and other headaches. This process was made possible by the fact that many of the distinguished authors who contributed to the book have been protagonists in the advancement of headache science in recent decades. The aim of the publishers of this third edition of the Handbook was to provide basic researchers and clinicians with an updated bibliographical resource that would increase all-round knowledge of the various forms of headache and also provide pointers for new lines of research. On reading this book it is clear that Professors Nappi and Moskowitz have accomplished this arduous task. The broad range of different skills and backgrounds (not only geographical but also cultural) of the editors and co-authors of this book not only provide a guarantee of its undisputed scientific quality, but also give it an international dimension."--Functional Neurology 2012; 29(1): 67


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