Spinal Cord Injury

Spinal Cord Injury, 1st Edition

Handbook of Clinical Neurology Series

Spinal Cord Injury, 1st Edition,Joost Verhaagen,John McDonald,ISBN9780444521378

Verhaagen   &   McDonald   





262 X 192

A comprehensive and detailed overview of the latest science of spinal cord injury, diagnosis and treatment

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Key Features

*Comprehensive coverage of the latest scientific understanding of spinal cord injuries
*Detailed coverage of current treatment best practices and potential future treatments
*Connects leading edge research programs to future treatment opportunities 


Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists.


Neuroscience and Clinical Neurology research specialists and practicing neurologists.

Joost Verhaagen

Affiliations and Expertise

Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

John McDonald

Affiliations and Expertise

Executive Vice President and Director, The International Center for Spinal Cord Injury, Baltimore, MD, USA

Spinal Cord Injury, 1st Edition



List of contributors

Section 1 Developmental and anatomical perspectives

1. Development and maturation of the spinal cord: implications of molecular and genetic defects

2. Anatomy and biomechanics of the spinal column and cord

Section 2 Diagnosis and prognosis

3. Clinical diagnosis and prognosis following spinal cord injury

4. Clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury

5. Concepts of aging with paralysis: implications for recovery and treatment

6. Advanced MRI strategies for assessing spinal cord injury

Section 3 Acute spinal cord injury: medical, surgical, and rehabilitative management

7. Advances in the management of spinal cord and spinal column injuries

8. Spinal cord injuries in children and adolescents

9. The changing landscape of spinal cord injury

10. Surgical treatments to restore function control in spinal cord injury

11. Advances in the rehabilitation management of acute spinal cord injury

12. Spasticity

13. Disordered cardiovascular control after spinal cord injury

14. New concepts in the prevention of pressure sores

15. Functional electrical stimulation for bladder, bowel, and sexual function

16. Evidence-based therapy for recovery of function after spinal cord injury

17. Functional electrical stimulation: restoration of respiratory function

18. Spinal cord stimulation: therapeutic benefits and movement generation after spinal cord injury

19. Promoting optimal functioning in spinal cord injury: the role of rehabilitation psychology

Section 4 Chronic spinal cord injury - the changing perspective of neurorestorative rehabilitation, activity-based and surgical restoration therapies

20. The changing field of rehabilitation: optimizing spontaneous regeneration and functional recovery

21. The longitudinal spinal cord injury: lessons from intraspinal plexus, cauda equina and medullary conus lesions

22. Post-traumatic syringomyelia: CSF hydrodynamic changes following spinal cord injury are the driving force in the development of PTSM

23. Post-traumatic deformity: prevention and management

Section 5 Preclinical research - bridging the gap between bench and bedside

24. Spinal cord injury clinical trials: translational process, review of past and proposed acute trials with reference to recommended trial guidelines

25. Translating preclinical approaches into human application

26. Translational spinal cord injury research: preclinical guidelines and challenges

27. Brain-machine interfaces and transcranial stimulation: future implications for directing functional movement and improving function after spinal injury in humans

28. Approaches to repairing the damaged spinal cord: overview

29. Limiting spinal cord injury by pharmacological intervention

30. Harmful and beneficial effects of inflammation after spinal cord injury: potential therapeutic implications

31. Defeating inhibition of regeneration by scar and myelin components

32. Realizing the maximum potential of Schwann cells to promote recovery from spinal cord injury

33. Repair of central nervous system lesions by transplantation of olfactory ensheathing cells

34. Cell transplantation: stem cells and precursor cells

35. Gene therapy, neurotrophic factors and spinal cord regeneration

36. Scaffolds to promote spinal cord regeneration

37. Molecular target discovery for neural repair in the functional genomics era

38. Combination therapies


Quotes and reviews

"Providing the latest information on all aspects of spinal cord injury, this volume supplants a 1992 work published in the Handbook of Clinical Neurology series titled Spinal Cord Trauma. Bridging the gap between bench and bedside, coverage encompasses diagnosis and prognosis; medical, surgical, and rehabilitative management of acute spinal cord injury; therapies for chronic spinal cord injury; and preclinical research."--Reference & Research Book News, October 2013

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