* Clinical data on groundbreaking advancements in the understanding of basic sleep science
* Invaluable information on new therapies and drug protocols for sleep disorders
* A state-of-the-art reference that includes the role of genetics in sleep medicine
Sleep Disorders Part 1 offers a glimpse of developments that focus on diagnostic techniques in the field of neurobiology of sleep. This part discusses the models of the rapid eye movement (REM) sleep mechanism; issues regarding sleep states, stages, and memory consolidation; and advances in the understanding of the sleep-wake genes, gene products, the circadian clock, and the role of sleep duration.
This book explains noninvasive neuroimaging studies, particularly positron emission tomographic and single photon emission computed tomographic scans. It further discusses advances in clinical science, including concepts about neurobiology of sleep, narcolepsy-cataplexy, therapy, and laboratory techniques. The significant advances in therapy have led to the addition of new drugs for the treatment of different sleeping disorders, as described in this book.
Sleep is essential to humans. Awareness of its true importance leads to the development and acceptance of sleep medicines in the market.
Neuroscience research workers
Sleep Disorders Part I, 1st Edition
SECTION 1: History of sleep medicine
History of sleep medicine.
SECTION 2: Basic science and methods
Normal sleep- recording and scoring techniques. Assessment of daytime sleepiness. Actigraphic monitoring of sleep and circadian rhythms. Video Recordings and Video Polysomnography. Functional neuroimaging in sleep, sleep deprivation and sleep disorders.
SECTION 3: Basic mechanisms of sleep
The Phylogeny of Sleep. Ontogeny of EEG-sleep from neonatal through infancy periods. Neurobiology of waking and sleeping. Neurobiology of REM sleep. Neurochemistry of sleep - an overview of animal experimental work. Molecular neurobiology of sleep. Manifestations and functional implications of sleep homeostasis. Thermoregulation in wakefulness and sleep in humans. Cytokines in immune function and sleep regulation. Endocrine and metabolic changes during sleep. Sleep, memory and molecular neurobiology.
SECTION 4: Clinical aspects of sleep disorders
Epidemiology of sleep disorders. Cardiovascular and cerebrovascular physiology in sleep. Cardiovascular diseases and sleep apnea. Alterations in gastrointestinal functioning during sleep. Sleep and genitourinary systems: physiology and disorders. Sleep enuresis. Respiratory physiology in sleep and wakefulness. Obstructive sleep apnea: diagnosis, risk factors and pathophysiology. Upper airway resistance syndrome. Central sleep apnea. Positive pressure treatment of obstructive sleep apnea syndrome. Medical and surgical treatment of obstructive sleep apnea syndrome, including dental appliances. Non-invasive positive ventilation in the treatment of sleep related breathing disorders. Sleep and pulmonary diseases. Sleep-associated respiratory disorders and their psycho-behavioral consequences in children. Sudden death in infants during sleep. Neurobiology and the neurological basis of dreaming. Abnormal dreams and nightmare disorders. Sleep and psychiatric diseases. Sleep-related eating disorder. Alcohol, toxins and medications as a cause of sleep dysfunction. Sleep, pain, fibromyalgia and chronic fatigue syndrome. Women and sleep. Normal and abnormal sleep in the elderly.