* A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology.
* International list of contributors including the leading workers in the field.
* Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.
This volume’s primary goal is to provide a comprehensive understanding of recent developments and advancements in the study of ataxic disorders. Beginning with an examination of the cerebellar region, and then progressing to a fresh perspective on the clinical aspects of the various forms of ataxia, this handbook gives clinicians a state-of-the-art reference for the management of the many etiologies and neurological manifestations of ataxic disorders.
Clinicians will gain a broader understanding of generative ataxias and the genetic disorders associated with them. In addition, new neurophysiological and imaging techniques are discussed, along with an in-depth examination of the treatment and management protocols of ataxic diseases.
Neuroscience research workers
Ataxic Disorders, 1st Edition
The cerebellum - structure and connections; Physiology of clinical dysfunction of the cerebellum; Oculomotor aspects of the hereditary cerebellar ataxias; Magnetic resonance and nuclear medicine imaging studies in ataxic disease; Neuropathology of degenerative ataxias; Approach to ataxic diseases
Acquired ataxias, infectious and para-infectious; Ataxia in patients with brain infarcts and hemorrhages; Ataxia resulting from posterior fossa tumors of childhood and other mass lesions; Nutritional cerebellar degeneration, with comments on its relationship to Wernicke disease and alcoholism; Immune-mediated acquired ataxias; Toxic agents causing cerebellar ataxias; Paraneoplastic cerebellar degeneration
Epidemiology and population genetics of degenerative ataxias; Sporadic adult onset ataxia of unknown aetiology
DEGENERATIVE ATAXIAS – MITOCHONDRIAL, AUTOSOMAL RECESSIVE AND X-LINKED
Overview of autosomal recessive ataxias; Friedrich’s ataxia; Ataxia with vitamin E deficiency and abetalipoproteinemia; Ataxia-telangiectasia; Autosomal recessive cerebellar ataxias with oculomotor apraxia; Other autosomal recessive and childhood ataxias; Ataxia in mitochondrial disorders; Fragile X-associated tremor/ataxia syndrome
DEGENERATIVE ATAXIAS – AUTOSOMAL DOMINANT
Overview of autosomal dominant ataxias; Spinocerebellar ataxia type 1, 2; Machado-Joseph disease/spinocerebellar ataxia type 3; Spinocerebellar ataxia type 5, 6, 7; Clinical and genetic features of spinocerebellar ataxia type 8; Spinocerebellar ataxia type 10, 11, 12, 13, 14, 15, 20, 25, 28; Other spinocerebellar ataxias; Dentatorubral-pallidoluysian atrophy; Episodic ataxias 1 and 2
Ataxias related to sensory neuropathies; Frontal lobe ataxia; Balance and gait problems in the elderly; Treatment and management issues in ataxic disease