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Caveolae and Lipid Rafts : Roles in Signal Transduction & the Pathogenesis of Human Disease
 
 

Caveolae and Lipid Rafts : Roles in Signal Transduction & the Pathogenesis of Human Disease, 1st Edition

Advances in Molecular and Cell Biology

 
Caveolae and Lipid Rafts : Roles in Signal Transduction & the Pathogenesis of Human Disease, 1st Edition,Edward Bittar,ISBN9780444515001
 
 
 

E Bittar   

Elsevier Science

9780444515001

9780080458601

264

229 X 152

The first book available dedicated to caveolae in human diseases and cellular metabolism.

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Description

Caveolae (latin for little caves) are small structures found at the surface of cells. They are responsible for the regulation of important metabolic pathway. As a consequence, they may play a critical role in several human diseases such as atherosclerosis, cancer, diabetes, and muscular dystrophies. This book analyzes the role and function of caveolae in these aspects and serves as the first textbook currently available on caveolae/caveolin.

Readership

Cell biologists, pharmaceutical researchers, and graduate level and medical students.

Edward Bittar

Affiliations and Expertise

Department of Physiology, University of Wisconsin Medical School, Madison, USA

View additional works by Edward Bittar

Caveolae and Lipid Rafts : Roles in Signal Transduction & the Pathogenesis of Human Disease, 1st Edition

Section 1: Caveolae organization and role in lipid cholesterol metabolism.
Lipid rafts and caveolae organization.
Caveolae and the regulation of cellular cholesterol homeostasis.
Section 2: Caveolae and the regulation of endocytosis.
The Caveolae Internalization Machinery.
Lipid raft mediated entry of bacteria into host cells.
Section 3: Examples of the role of caveolins in cell signaling.
The caveolin interaction with the endothelial nitric oxide synthase (eNOS).
Caveolae and Estrogen Receptor Signaling.
eNOS regulation by sphingosine 1-phosphate and caveolin.
Insulin signaling and caveolae.
Section 4: Caveolae and pathologies.
Caveolin-3, Caveolae, and Hereditary Muscle Diseases.
Caveolae and Caveolins in the Vascular System.
Caveolin Proteins in Cardio-pulmonary Disease and Lung Cancers.
 
 
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