»
Basic Biology and Clinical Impact of Immunosenescence
 
 

Basic Biology and Clinical Impact of Immunosenescence, 1st Edition

 
Basic Biology and Clinical Impact of Immunosenescence, 1st Edition,G. Pawelec,ISBN9780444513168
 
 
 

  

Elsevier Science

9780444513168

9780080546483

322

Print Book + eBook

USD 183.00
USD 305.00

Buy both together and save 40%

Print Book

Hardcover

In Stock

Estimated Delivery Time
USD 150.00

eBook
eBook Overview

DRM Free included formats: PDF

USD 155.00
Add to Cart
 
 

Description

Ageing is of perennial interest as a universal feature in all human societies. The genetic background and biochemical bases of ageing processes are currently being revealed in unprecedented detail. It is emerging that one of the main hurdles to be overcome in achieving a long and healthy lifespan is the maintenance of a properly functioning immune system. The main cause of death in people who have achieved "successful ageing" (which mostly means not having succumbed to cancer or cardiovascular disease) is infectious disease, caused by immunosenescence. This book contains chapters by many of the leaders in the field of immune-related issues in ageing and remediation.


G. Pawelec

Affiliations and Expertise

Professor of Experimental Immunology, University of Tübingen, Center for Medical Research (ZMF), Waldhörnlestr. 22, D-72072, Germany

Basic Biology and Clinical Impact of Immunosenescence, 1st Edition

Preface. 1. The OCTO and NONA immune longitudinal studies: a review of 11 years' studies of Swedish very old humans (A. Wikby, B. Johansson, F. Ferguson). 2. Immune measures which predict nine-year survival in an elderly population sample (F. Huppert, E. Pinto et al.). 3. Immunological and immunogenetic markers of successful and unsuccessful ageing (G. Candore, G. Colonna-Romano et al.). 4. Developmental aspects of the thymus in ageing (A. Globerson). 5. Effective immunity during late life: a possible role for the thymus (J. Pindo-Lopez, R. Aspinall). 6. Alterations in signal transduction in T lymphocytes and neutrophils with ageing (T. Fulop, K. Hirokawa et al.). 7. CD28 downregulation and expression of NK-associated receptors on T cells in ageing and situations of chronic activation of the immune system (J. Casado, O. DelaRosa et al.). 8. Characterization of NK cells in the elderly
(E. Mariani, A. Facchini). 9. T cell ageing and immune surveillance (J. McLeod). 10. A road to ruins: an insight into immunosenescence (S. Gupta). 11. Genetic damage and ageing T cells (O. Ross, M. Curran et al.). 12. Role of DNA-dependent protein kinase (DNA-PK), a protein with multiple intracellular functions, in cells of the ageing immune system
(D. Frasca, L. Guidi, G. Doria). 13. Linker histone H1o gene expression during ageing and after the effect of histone deacetylase inhibitors in human diploid fibroblasts and T lymphocytes (T.G. Sourlingas, K.E. Sekeri-Pataryas). 14.
Zinc and the immune system of elderly (K.-H. Ibs, P. Gabriel, L. Rink). 15. Altered zinc binding by metallothioneins in immune-neuroendocrine senescence: a vicious circle between metallothioneins and chaperones? (E. Mocchegiani, R. Giacconi et al.). 16. T cell exhaustion and ageing: Is replicative senescence relevant? (R.B. Effros). 17.
Cultured T cell clones as models for immunosenescence (G. Pawelec).
 
 
Cyber Monday SALE Upto 50 Percent OFF | Use Code CYBER14
Shop with Confidence

Free Shipping around the world
▪ Broad range of products
▪ 30 days return policy
FAQ

Contact Us