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Omic Studies of Neurodegenerative Disease - Part B
1st Edition, Volume 122 - September 16, 2015
Editor: Michael J. Hurley
Language: English
Hardback ISBN:9780128047620
9 7 8 - 0 - 1 2 - 8 0 4 7 6 2 - 0
eBook ISBN:9780128047637
9 7 8 - 0 - 1 2 - 8 0 4 7 6 3 - 7
Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, alon…Read more
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Omic Studies of Neurodegenerative Disease: Part B is part of a well-established international series on neuroscience that examines major areas of basic and clinical research, along with emerging and promising subfields.
The book informs the reader on the current state of the studies used to evaluate the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research.
Provides the expertise of leading contributors in the field
Demonstrates how findings in the fields of genomics, proteomics, and metabolomic studies can combined for further insights
Informs the reader on the current state of the studies used to study the mechanisms, causes, and treatment of neurodegeneration through a combination of literature reviews and examples of current research
The volume will appeal to a wide audience including students and researchers from across the life science community, particularly those interested in neuroscience.
Preface
Chapter One: Utility of Autoantibodies as Biomarkers for Diagnosis and Staging of Neurodegenerative Diseases
Abstract
1 Introduction: A Brief History of Autoantibodies
2 A Causal Role for Autoantibodies Revealed in Well-Known Autoimmune Diseases
3 Autoantibodies in Cancer: Byproduct or Biomarker?
4 Escalating Involvement of Autoantibodies in Neurological and Neurocognitive Disorders
5 Autoantibodies: Abundant, Ubiquitous, and Clinically Useful
6 Methods of Autoantibody Detection in Biofluids
7 Utility of Autoantibodies as Biomarkers of Disease
8 Conclusions and Perspectives
Acknowledgments
Chapter Two: Metabolomics of Neurodegenerative Diseases
Abstract
1 Metabolomics in Medicine
2 Metabolomics Biomarkers of Disease
3 Metabolomics Biomarker Discovery in Neurodegenerative Disorders
4 Summary
Acknowledgments
Chapter Three: Parkinson's Disease: In Vivo Brain Metabolomics by MRS
Abstract
1 Proton MRS
2 1H MRS: Compounds Detectable In Vivo
3 Phosphorus MRS
4 Mitochondrial Dysfunction
5 Other Findings
6 High Magnetic Field
7 Parkinson's Disease and Solvent Exposure
8 Conclusions
Chapter Four: Recent Advances and Applications of Metabolomics to Investigate Neurodegenerative Diseases
Abstract
1 Introduction
2 Metabolomics and Neurodegenerative Disorders
3 Conclusions
Chapter Five: Lipidomics of Human Brain Aging and Alzheimer's Disease Pathology
Abstract
1 Introduction
2 Lipidomics of Human Brain
3 Lipidomics of Human Brain Aging
4 Lipidomics of Alzheimer's Disease Pathology
5 Summary and Future Prospects
Acknowledgments
Index
Contents of Recent Volumes
No. of pages: 250
Language: English
Edition: 1
Volume: 122
Published: September 16, 2015
Imprint: Academic Press
Hardback ISBN: 9780128047620
eBook ISBN: 9780128047637
MH
Michael J. Hurley
Michael Hurley has 20 years of experience conducting research in to the cause and consequence of neurodegeneration in brain. He currently works at Imperial College London.
Affiliations and expertise
Imperial College London, UK
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