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Sleep and Neurologic Disease
1st Edition - January 17, 2017
Editor: Mitchell G. Miglis
Language: English
Hardback ISBN:9780128040744
9 7 8 - 0 - 1 2 - 8 0 4 0 7 4 - 4
eBook ISBN:9780128041123
9 7 8 - 0 - 1 2 - 8 0 4 1 1 2 - 3
Sleep and Neurologic Disease reviews how common neurologic illnesses, such as Parkinson’s Disease and Alzheimer’s dementia impact sleep. In addition, the book discusses how commo…Read more
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Sleep and Neurologic Disease reviews how common neurologic illnesses, such as Parkinson’s Disease and Alzheimer’s dementia impact sleep. In addition, the book discusses how common primary sleep disorders influence neurologic diseases, such as the relationship between obstructive sleep apnea and stroke, as well as their association with various primary headache disorders and epilepsy syndromes.
The utilization of sleep technology, such as polysomnography, multiple sleep latency testing, actigraphy, laboratory and CSF testing is also covered. The book is written for the practicing neurologist, sleep physician, neuroscientist, and epidemiologist studying sleep.
Reviews how common neurological illnesses impact sleep and the impact sleep disorders have on neurologic disease
Up-to-date, comprehensive overview written for practicing neurologists, sleep physicians, neuroscientists, and epidemiologists
Includes informative discussions on sleep physiology, circadian rhythms, sleep and stroke, and treatment options for neurologists
For neurologists, sleep physicians, neuroscientists and epidemiologists studying sleep
List of Contributors
Foreword
Preface
Chapter 1: Anatomy and Physiology of Normal Sleep
Abstract
Introduction
Initial Discoveries of Sleep Circuitry
Neuroanatomy and Neurotransmitters
Sleep-wake Circuitry
Circadian and Homeostatic Regulation of Sleep
Conclusions
Chapter 2: Anatomy and Physiology of the Circadian System
Abstract
Biological Rhythms at the Origin of the Circadian Timing System
Endogenous Circadian Rhythms
The Circadian Timing System
Outputs of the Central Clock
Entrainment of the Circadian Timing System
Conclusions
Chapter 3: The Functions of Sleep and the Effects of Sleep Deprivation
Abstract
Introduction
Sleep and Stress
Regulation of Appetite
GH, PRL, TSH, GnRH, and Testosterone
Mood, Emotional Stability and Reward Circuits
Emotional Maturation
Dreaming
Regulation of Pain
Cognitive Performance and the Effects of Sleep Deprivation
Accidents and Safety in Acute and Chronic Sleep Deprivation
Memory
Insight and Creativity, Memory
Immune Function
Conclusions
Chapter 4: Sleep and Cognitive Impairment
Abstract
Sleep Changes in Normal Aging
Sleep in Dementia
Sleep Disorders as a Risk Factor for Cognitive Impairment
Treatment
Conclusions
Chapter 5: Sleep and Movement Disorders
Abstract
Introduction
Parkinson’s Disease
Multiple System Atrophy
Dementia with Lewy Bodies
REM Sleep Behavior Disorder
α-Synucleinopathies and REM Sleep Behavior Disorder
Narcolepsy and REM Sleep Behavior Disorder
Restless Leg Syndrome
Huntington’s Disease
Wilson’s Disease
Conclusions
Acknowledgments
Chapter 6: Sleep and Stroke
Abstract
Introduction
Sleep Apnea is a Risk Factor for Stroke
Pathophysiology
Stroke Increases the Risk of Sleep Apnea
Stroke and the Sleep–Wake Cycle
Stroke, Parasomnias, and Sleep-Related Movement Disorders
Diagnosis
Treatment
Conclusions
Chapter 7: Sleep and Epilepsy
Abstract
Introduction
Circadian Patterns
Sleep Deprivation
Sleep Related Disorders
Conclusions
Future Directions
Chapter 8: Central Nervous System Hypersomnias
Abstract
Classification of CNS Hypersomnia Disorders
Historical Perspectives and Pathophysiology
Clinical Features
Diagnostic Procedures
Individual Pathologies
Conclusions
Chapter 9: Sleep and Multiple Sclerosis
Abstract
Introduction
Fatigue and the Association of Sleep Disorders in MS
Conclusions
Chapter 10: Sleep and Neuromuscular Disease
Abstract
Introduction
The Physiology of Normal Breathing
Mechanisms of Sleep Disturbances in Neuromuscular Disease
Assessments of Hypoventilation and Sleep Disturbance in Neuromuscular Disease
Treatment of Neuromuscular Hypoventilation
Central Hypoventilation Syndrome Due to Chronic Hypercapnia
Central Sleep Dysfunction in Neuromuscular Disease
Upper Motor Neuron Dysfunction
Restless Legs Syndrome in Neuromuscular Disease
Pain Secondary to Neuromuscular Disease
Evidence for Treatment of Sleep Disturbances in Neuromuscular Disease
Conclusions
Acknowledgment
Chapter 11: Sleep and Headache
Abstract
Introduction
The Clinical Relationship between Sleep and Headache Disorders
The Shared Neurobiological Substrate of Sleep and Headache
Headache Itself can Result in Sleep Disturbances
Sleep Disorders can Cause or Exacerbate Headache
Conclusions
Chapter 12: Sleep and the Autonomic Nervous System
Abstract
Introduction
Anatomy of the Autonomic and Sleep/Wake Systems
Normal Autonomic Function During Sleep
Measuring Autonomic Tone During Sleep
Autonomic Disorders with Prominent Sleep Disruption
Conclusions
Index
No. of pages: 268
Language: English
Edition: 1
Published: January 17, 2017
Imprint: Academic Press
Hardback ISBN: 9780128040744
eBook ISBN: 9780128041123
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Mitchell G. Miglis
Dr. Miglis is Clinical Assistant Professor of Neurology and Neurological Sciences and Clinical Assistant Professor of Psychiatry and Behavioral Sciences at Stanford University. He completed fellowship training in autonomic disorders at Harvard Medical School and sleep medicine at Stanford University. He is board certified in neurology and sleep medicine and serves on the sleep medicine section committee for the American Academy of Neurology. His clinical interests include the overlap of sleep and neurological disease, and his research focuses on autonomic impairment in sleep. He is a firm believer that good health begins with good sleep, and that the complete treatment of any patient with a neurological illness should include a thorough understanding of how their illness impacts the quality of their sleep.
Affiliations and expertise
Neurology Department, Stanford University School of Medicine, Stanford, CA, USA