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Anti-Angiogenesis Drug Discovery and Development
Volume 2
1st Edition - June 2, 2015
Editors: Atta-ur Rahman, Muhammad Iqbal Choudhary
Language: English
Paperback ISBN:9780128039632
9 7 8 - 0 - 1 2 - 8 0 3 9 6 3 - 2
eBook ISBN:9780128039649
9 7 8 - 0 - 1 2 - 8 0 3 9 6 4 - 9
The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the tr…Read more
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The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results.
Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews have been contributed by leading practitioners in drug discovery science and highlight the major developments in this exciting field in the last two decades. These reader-friendly chapters cover topics of great scientific importance, many of which are considered significant medical breakthroughs, making this book excellent reading both for the novice as well as for expert medicinal chemists and clinicians.
Edited and written by leading experts in angiogenesis drug development
Reviews recent advances in the field, such as coverage of anti-angiogenetic drugs in ovarian cancer
Reports current strategies and future outlook for anti-angiogenic therapy and cardiovascular diseases
Medicinal Chemistry and Pharmaceutical researchers
Preface
List of Contributors
Chapter 1: Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis
Abstract
Introduction
An Historical Overview of Angiogenesis
Types of Angiogenesis
The Mechanism of Normal Angiogenesis
Tumor Induced Angiogenesis
Assays for Angiogenesis
Mechanism of Angiogenesis Inhibition
Inhibitors of Growth Factors and Receptors
An Overview of Anti-Angiogenic Therapy
Conclusion
Acknowledgements
Conflict of Interest
Chapter 2: Development of In Vitro Method for Assaying Anti-Angiogenic Effect of Drugs
Abstract
Introduction
Collagen Gel Culture of Aortic Explant
Capillary Tube Formation
Immunohistochemistry of Angiogenic Factors
Adhesive Molecules (Integrins)
CD133 (Hematopoietic Stem/Progenitor Cell Marker)
Gene Array Analysis
Anti-Angiogenic Drugs
Collagen Gel Culture as an in Vitro Model for Studying Vascular Injury
Collagen Gel Culture of Various Organs
Conclusion
Acknowledgements
Conflict of Interest
Disclosures
Chapter 3: Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis: Which Actors to Target for Treatment?
Abstract
Introduction
Targeted Therapies in Use
Emergent Molecules in Phase III Clinical Trials
Emergent Molecules in Phase II Clinical Trials
Identification of Predictive Biomarkers of the Efficiency of Anti-Angiogenesis Treatments
Discussions
Acknowledgements
Conflict of Interest
Disclosure
Chapter 4: Inhibition of Angiogenesis in Cancer Management by Antioxidants: Ascorbate and P. leucotomos
Abstract
Introduction
Conclusion
Acknowledgements
Conflict of Interest
Disclosure
Chapter 5: Development of Novel Anti-Cancer Strategies Based on Angiogenesis Inhibition
Abstract
Introduction
Physiological Angiogenesis
Pathological Angiogenesis
Factors Responsible for Angiogenesis
Molecules Involved in Angiogenesis
Signal Transduction Pathways Involved in Angiogenesis
Strategies for Targeting Angiogenesis
Naturally Occurring Inhibitors
Mimics for Angiogenesis
Synthetic Inhibitors
Concluding Remarks
Acknowledgements
Conflict of Interest
Chapter 6: Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer
Abstract
Introduction
Mechanisms of Action
Resistance
General Toxicities
Agents Bevacizumab
Aflibercept (VEGF Trap)
Additional Antiangiogenics
Novel Delivery of Antiangiogenics
Limitations and Future Clinical Use
Registration Strategies
Combination Antivascular Therapies
Conclusion
Acknowledgements
Conflict of Interest
Competing Interests
Chapter 7: STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy?
Abstract
Introduction: Angiogenesis, VEGF and STAT3
Summary
Acknowledgements
Conflict of Interest
Chapter 8: Anti-Angiogenic Therapy and Cardiovascular Diseases: Current Strategies and Future Perspectives
Abstract
Introduction
Angiogenesis
Association of Angiogenesis with Atherosclerosis
Angiogenesis and Neointimal Growth
Hypoxia and Intraplaque Neovascularization
Inflammatory Cells and Neovascularization
Antioxidants in Angiogenesis and Atherosclerosis
Therapeutic Approaches for Treating Angiogenesis
Placental Growth Factor
Fibroblast Growth Factor Inhibition
Vascular Endothelial Growth Factor Receptor
Vascular Endothelial Growth Factor -C,-D
Interleukin Therapy
Statins for Treating Pathological Angiogenesis
Redox Control of Angiogenesis
Natural Polyphenols as Anti-Angiogenic Drugs
Gene Therapy
Nanomedicinal Approaches for Treating Pathological Angiogenesis in Cardiovascular Diseases
Anti-Angiogenesis Drug Toxicity
Exciting Future Prospects
Acknowledgements
Conflict of Interest
Abbreviations
Subject Index
No. of pages: 326
Language: English
Edition: 1
Published: June 2, 2015
Imprint: Bentham Science Publishers
Paperback ISBN: 9780128039632
eBook ISBN: 9780128039649
AR
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan
MC
Muhammad Iqbal Choudhary
Muhammad Choudhary, PhD, is a Professor of the International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan. He is a member of the Royal Society of Chemistry, London; American Chemical Society; International Union of Pure and Applied Chemistry (IUPAC); American Society of Pharmacology; New York Academy of Sciences; Federation of Asian Chemical Societies (FACS); and he serves on the executive board of the Asian Network of Research on Anti Diabetic Plants (ANRAP). He is a recipient of the National Book Foundation's Prize for Chemistry and the Economic Cooperation Organization (ECO) Award in Education, 2006, given by the President of Azerbaijan. He has published 24 books, more than 570 papers, and 20 patents.
Affiliations and expertise
Professor, International Center for Chemical and Biological Sciences, (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Karachi, Pakistan
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