This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presen…Read more
Purchase options
LIMITED OFFER
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
This volume of The Enzymes summarizes the most important discoveries associated with a group of enzymes that play an important role in normal biological processes as presented and discussed by leaders authorities in the field.
Contributions from leading authorities
Informs and updates on all the latest developments in the field of enzymes
Scientists interested in learning more about recent developments in the field and physicians interested in understanding the mechanistic basis of diseases associated with deregulated PAF-AH functions.
Preface
Chapter One: Overview of PAF-Degrading Enzymes
Abstract
1 Introduction
2 Intracellular PAF-AH I
3 Intracellular PAF-AH II
4 Plasma PAF-AH
5 Conclusion
Chapter Two: Intracellular PAF-Acetylhydrolase Type I
Abstract
1 Introduction and History
2 Identification of Intracellular PAF-AH, Isoform Ib
3 Nomenclature of PAF-AH Ib Subunits
4 Structure of PAF-AH Ib
5 Physiological Roles of PAF-AH Ib
6 Remaining Questions and Future Prospects
Acknowledgments
Chapter Three: Platelet-Activating Factor Acetylhydrolase and Brain Development
Abstract
1 Introduction
2 Genetics of Human Lissencephaly and Recognition of the LIS1-Encoded Protein as PAFAH1B1
3 Role of Pafah1b and Platelet-Activating Factor in Brain Development
4 Coordination of Brain Platelet-Activating Factor Acetylhydrolase Signaling and Reelin Signaling in Mouse Brain
5 Roles of “Brain” Platelet-Activating Factor Acetylhydrolase in Testicular Development and Spermatogenesis
6 Conclusions
Chapter Four: Intracellular Platelet-Activating Factor Acetylhydrolase, Type II: A Unique Cellular Phospholipase A2 That Hydrolyzes Oxidatively Modified Phospholipids
Abstract
1 Introduction
2 Structure of PAF-AH (II)
3 Substrate Specificity of PAF-AH (II)
4 Biological Roles of PAF-AH (II)
5 Regulation of PAF-AH (II)
6 Future Prospects
Acknowledgments
Chapter Five: Trafficking and Oligomeric Regulation of Platelet-Activating Factor Acetylhydrolase Type II
Abstract
1 Introduction
2 Trafficking of PAFAH-II
3 Oligomeric Regulation of PAFAH-II
4 Conclusions and Future Work
Acknowledgment
Chapter Six: Plasma PAF-AH (PLA2G7): Biochemical Properties, Association with LDLs and HDLs, and Regulation of Expression
Abstract
1 Introduction and Perspectives
2 Biochemical Properties of Plasma PAF-AH
3 Association with Lipoproteins
4 Regulation of PAF-AH Expression
5 Conclusions
Acknowledgments
Chapter Seven: Crystal Structure and Atomic Level Analysis of Plasma PAF-AH
Abstract
1 Introduction
2 Plasma PAF-AH Structural Overview
3 Lipoprotein Particle and Membrane Interactions
4 Plasma PAF-AH Ligand Complexes at the Active Site
5 Conclusions
Acknowledgments
Chapter Eight: Naturally Occurring Missense Mutation in Plasma PAF-AH Among the Japanese Population
Abstract
1 Introduction
2 Effect of Plasma PAF-AH Mutation on Enzyme Substrates
2 Development of PAFAH-Specific Inhibitor and Preclinical Studies
3 Clinical Trials with PAFAH-Specific Inhibitor Darapladib
4 Genetic Variability of PAFAH/PLA2G7
5 Conclusions
Acknowledgments
Chapter Ten: Diverse Functions of Plasma PAF-AH in Tumorigenesis
Abstract
1 Introduction and Perspectives
2 Biological Consequences of Altered PAF-AH Expression/Function
3 Specific Examples
4 PAFAH Mutations in Cancer
5 PAF-AH as a Cancer Biomarker and Therapeutic Target
6 Conclusions
Acknowledgments
Author Index
No. of pages: 222
Language: English
Edition: 1
Volume: 38
Published: November 24, 2015
Imprint: Academic Press
Hardback ISBN: 9780128039083
eBook ISBN: 9780128039465
FT
Fuyuhiko Tamanoi
Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.
Affiliations and expertise
Biochemist, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA
DS
Diana Stafforini
Dr. Diana Stafforini works at the Huntsman Cancer Institute at the University of Utah School of Medicine.
Affiliations and expertise
University of Utah, Salt Lake City, UT, USA
KI
Keizo Inoue
Professor Inoue works at the Teikyo University, School of Pharmacy, Japan.
Affiliations and expertise
Teikyo University, Itabashi, Japan
Read Platelet-Activating Factor Acetylhydrolases (PAF-AH) on ScienceDirect