Hematopoiesis

1st Edition, Volume 118 - April 27, 2016
Editor: Emery Bresnick
Language: English
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 3 3 1 9 - 7
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 3 3 2 6 - 5

Hematopoiesis, the latest volume in the Current Topics in Developmental Biology, covers hematopoiesis, with contributions from an international board of authors. Its chapters pro… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code is needed.

Institutional subscription on ScienceDirect

Request a sales quote

Hematopoiesis, the latest volume in the Current Topics in Developmental Biology, covers hematopoiesis, with contributions from an international board of authors. Its chapters provide a comprehensive set of reviews covering such topics as the regulation of blood stem cell development, epigenetic mechanisms controlling erythropoiesis, and regulatory RNAs/HSCs.

Preface
Chapter One: Regulation of Blood Stem Cell Development
- Abstract
- 1 Introduction
Chapter Two: Hematopoietic Stem Cell and Its Bone Marrow Niche
- Abstract
- 1 Introduction
- 2 Evolution of the Stem Cell Niche Concept
- 3 Location Matters
- 4 Cellular Participants in the Bone Marrow Microenvironment
- 5 The Sympathetic Nervous System
- 6 HSC Mobilization from the BM Niche
- 7 Niche of Hematopoietic Malignancies
- 8 Perspectives
Chapter Three: The Hematopoietic Stem and Progenitor Cell Cistrome: GATA Factor-Dependent cis-Regulatory Mechanisms
- Abstract
- 1 cis-Regulatory Mechanisms
- 2 GATA Factor Interactions with DNA and Chromatin
- 3 Components of Scl/TAL1 and GATA Factor Complexes at E-box–GATA Elements
- 4 HSPC Cistrome
- 5 Perspective
Chapter Four: ETS Transcription Factor ETV2/ER71/Etsrp in Hematopoietic and Vascular Development
- Abstract
- 1 Introduction
- 2 Etv2 Is Transiently Expressed in the Hemangiogenic Progenitors
- 3 ETV2 Is Sufficient to Induce Hematopoietic and Endothelial Cell Formation
- 4 Nonredundant and Transient Role of ETV2 in Hematopoietic and Endothelial Cell Formation
- 5 ETV2, VEGF, and FLK1 in Hematopoietic and Endothelial Cell Formation
- 6 ETV2 Regulates Hemangiogenic versus Cardiac Mesoderm Outcome
- 7 ETS Hierarchy and ETS Switching Mechanisms in Hematopoietic and Vascular Development
- 8 ETV2 in Definitive Hematopoietic Program and Function
- 9 Regulation of Etv2 Expression
- 10 Closing Thoughts and Future Directions
- Acknowledgments
Chapter Five: Taking the Leap: Runx1 in the Formation of Blood from Endothelium
- Abstract
- 1 The Three Waves of Blood Cell Formation
- 2 The Role of Runx1 in the Formation of Embryonic Progenitors and HSCs
- 3 The Temporal Requirement for Runx1 in Hemogenic Endothelium
- 4 Downstream Runx1 Targets That Execute the Endothelial to Hematopoietic Cell Transition
- 5 Epigenetic Regulation by Runx1
- 6 Cis-Acting Sequences Regulating Runx1 Transcription
- 7 The Gene Regulatory Network Upstream of Runx1
- 8 Signaling Pathways Regulating Runx1 Expression in the Aorta
- 9 Conclusions and Future Directions
Chapter Six: SCL/TAL1 in Hematopoiesis and Cellular Reprogramming
- Abstract
- 1 Introduction
- 2 SCL Function During Development
- 3 The Long, the Intermediate, and the Short (Term): HSC Function and Scl
- 4 The SCL Complex
- 5 SCL and Cellular Reprogramming
- 6 Concluding Remarks
- Acknowledgments
Chapter Seven: Navigating Transcriptional Coregulator Ensembles to Establish Genetic Networks: A GATA Factor Perspective
- Abstract
- 1 Introduction
- 2 The GATA Factor Coregulator Repertoire
- 3 GATA Factor Posttranslational Modifications
- 4 Transcription Factor Cooperation
- 5 Assembling and Deciphering a Coregulator Matrix Governing GATA Factor Function
Chapter Eight: Noncoding Regulatory RNAs in Hematopoiesis
- Abstract
- 1 Introduction
- 2 Emerging Importance of Regulatory RNAs in Hematopoiesis
- 3 Regulatory RNAs in Normal Hematopoiesis
- 4 ncRNAs in Hematopoietic Malignancies
- 5 ncRNAs as Biomarkers
- 6 LncRNA Databases
- 7 Conclusions
- Acknowledgments
Index

Purchase options

Save 50% on book bundles

Institutional subscription on ScienceDirect

Emery Bresnick