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Essays on Developmental Biology Part A
1st Edition, Volume 116 - March 9, 2016
Editor: Paul Wassarman
Language: English
Hardback ISBN:9780128029565
9 7 8 - 0 - 1 2 - 8 0 2 9 5 6 - 5
eBook ISBN:9780128029763
9 7 8 - 0 - 1 2 - 8 0 2 9 7 6 - 3
In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden” anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto…Read more
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In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden” anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come.
Covers the area of developmental processes for a variety of model organisms
International board of authors
Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman
Researchers in cell, developmental, and molecular biology; genetics.
Preface
Essays on Developmental Biology-2016
Chapter One: Seeing is Believing, or How GFP Changed My Approach to Science
Abstract
1 From Fly Mutants to Developmental Control Genes
2 From Mutants to Cell Behavior
3 From Flies to Fish
4 From GFP to GFP Binders
5 The Crispr Revolution or Bringing It All Together
Acknowledgments
Chapter Two: The Notch-Mediated Proliferation Circuitry
Abstract
1 Notch Can Have Opposing Effects on Proliferation
2 Notch Affects Proliferation in Both Cell-Autonomous and Non-Cell-Autonomous Manners
3 Notch and Proliferation in Oncogenesis
4 Proliferative Effects of Notch in Stem Cells
5 Notch Synergies in Proliferation
6 A Notch–JNK Signaling Axis Couples Proliferation and Invasiveness
7 Notch Synergies in Oncogenesis: A Hypothesis
Chapter Three: Defining the Path from Stem Cells to Differentiated Tissue
Abstract
Chapter Four: Neuregulin/ErbB Signaling in Developmental Myelin Formation and Nerve Repair
Abstract
1 Introduction
2 Schwann Cell Precursors
3 Entry into the Myelination Program
4 Nrg1 and Other Extrinsic Signals that Control Myelination
5 Proteolytic Processing is Rate Limiting for Nrg1 Activity and Function
6 Rates of Protein Synthesis Control the End of Myelination and Myelin Thickness
7 Nrg1 and Remyelination After Injury
Acknowledgments
Chapter Five: Oocyte Meiotic Spindle Assembly and Function
Abstract
1 Introduction
2 Maintain Parity or Pare Down: Mitotic Versus Meiotic Cell Division
3 Centrosomes: The Stars of Mitotic Spindle Poles
4 The Curious Structure of (Some) Oocyte Meiotic Spindles: Acentriolar Poles
5 The Curious Structure of Oocyte Meiotic Spindles, Part 2: Tiled Microtubules
1 Genetic Analysis of Genes Required for Germ Plasm Assembly
2 Oocyte Specification and Dynein-Mediated RNA Transport
3 Oocyte Polarization and Kinesin-Mediated Transport of osk RNA Within the Oocyte
4 cis-Acting Sequences and RNA Transport Particles
5 Translational Control of osk RNA
6 A Noncoding RNA Function for osk
7 Oskar Protein Structure and Function
8 Assembly of Germ Plasm
9 Effector RNA Localization
10 Summary and Outlook
Acknowledgments
Chapter Forty: Emerging Modeling Concepts and Solutions in Stem Cell Research
Abstract
1 Predictive Stem Cell Biology and Quantitative Models
2 Network-Based and Cell-Based Models
3 Multiscale Models Involving Gene Networks and Cell Signaling
4 Deterministic Versus Stochastic Scenarios, Heterogeneity of Stem Cells
5 Modularity, Robustness, and Feedback Control in Pluripotency Gene Networks
6 Key Problems and Future Directions
Index
No. of pages: 770
Language: English
Edition: 1
Volume: 116
Published: March 9, 2016
Imprint: Academic Press
Hardback ISBN: 9780128029565
eBook ISBN: 9780128029763
PW
Paul Wassarman
Paul M. Wassarman, the Series Editor of CTDB since 2007, is Professor in the Dept. Developmental and Regenerative Biology at the Icahn School of Medicine at Mount Sinai in New York City. He received a Ph.D. in biochemistry from Brandeis University where he carried out thesis research in the Graduate Dept. Biochemistry with Professor Nathan O. Kaplan. In 1967 Wassarman joined the Division of Structural Studies at the MRC, Laboratory of Molecular Biology in Cambridge, England as a Helen Hay Whitney Foundation Fellow with Sir John C. Kendrew. In 1972 he joined the faculty of the Dept. Biological Chemistry at Harvard Medical School and in 1986 moved to the Roche Institute of Molecular Biology where he was Chair of the Dept. Cell and Developmental Biology and Adjunct Professor in the Dept. Cell Biology, New York University School of Medicine. In 1996 he moved to the Icahn School of Medicine at Mount Sinai where he was the Lillian and Henry M. Stratton Professorial Chair of the Dept. Molecular, Cell, and Developmental Biology. Wassarman has published more than 200 research papers and reviews, dealing primarily with mammalian oogenesis, fertilization, and early embryogenesis.
Affiliations and expertise
Icahn School of Medicine, Mount Sinai, USA
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