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The Neuronal Codes of the Cerebellum
1st Edition - October 7, 2015
Editor: Detlef Heck
Language: English
Paperback ISBN:9780128013861
9 7 8 - 0 - 1 2 - 8 0 1 3 8 6 - 1
eBook ISBN:9780128016756
9 7 8 - 0 - 1 2 - 8 0 1 6 7 5 - 6
The Neuronal Codes of the Cerebellum provides the most updated information on what is known on the topics of the cerebellum’s anatomy and single cell physiology, two areas whe…Read more
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provides the most updated information on what is known on the topics of the cerebellum’s anatomy and single cell physiology, two areas where there has been a gap in knowledge regarding the specific codes it uses to process information internally and convey commands to other brain regions. This has created difficulties for researchers and clinicians looking to develop an understanding of the mechanisms by which it contributes to behavior and how its dysfunction causes neurological symptoms.
Focused on findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes, this edited volume will aid scientists in overcoming that knowledge gap, also serving as the first resource to broadly address the different aspects of spike coding in the cerebellum that focuses on spike train analysis.
Compiles current knowledge about functioning of the cerebellum on a cellular basis and how information is encoded in the cerebellum
Highlights findings related to the neuronal code used by cerebellar neurons for the representation of behavioral and sensory processes
Contents include an introduction to the cerebellum and experimental/theoretical techniques, as well as the function of cerebral coding during disorder, learning, behavior generation, motor behavior, and more
Bridges the gap for cerebellar researchers between single cell biophysics/anatomic studies and behavioral studies
Incorporates various in vivo approaches with different behavioral paradigms in primates and rodents, modeling studies of coding, and in vitro approaches
Basic and clinical neuroscientists studying cerebellar disorders, systems neuroscientists, modelers and theoreticians
Foreword
Preface
Chapter 1. Signaling of Predictive and Feedback Information in Purkinje Cell Simple Spike Activity
Introduction
Purkinje Cell Discharge Signals Many Features of Movements
Purkinje Cell Discharge and Motor Errors
Computational Framework for Cerebellar Information Processing
Predictive and Feedback Signaling in Purkinje Cell Simple Spike Firing
Integration of Simple Spike Kinematic and Error Signals
Conclusions
Chapter 2. Deep Cerebellar Nuclei Rebound Firing In Vivo: Much Ado About Almost Nothing?
Introduction
The Computational Principles of the Cerebellum
The Deep Cerebellar Nuclei: The Cerebellum’s Gateway to the Brain
Rebound Depolarization: A Potential Feature of Spontaneously Active Neurons
Low-Threshold T-type Calcium Channels and Rebound Firing
Rebound Firing: An Intriguing and Effective Coding Mechanism that Converts Inhibitory Inputs to Excitatory Ones
Rebound Firing in the Deep Cerebellar Nuclei Neurons: A Prominent Biophysical Feature
Deep Cerebellar Nuclei Rebound Firing: The Devil is in the Details
Physiological Rebound Firing In Vivo
Conclusions
Chapter 3. Classical Conditioning of Timed Motor Responses: Neural Coding in Cerebellar Cortex and Cerebellar Nuclei
Behavioral Aspects of Eyeblink Conditioning
Neural Circuits Engaged during Eyeblink Conditioning
Neural Plasticity in the Cerebellar Cortex and Cerebellar Nuclei
Conclusions
Conflict of Interest
Chapter 4. How the Vestibulocerebellum Builds an Internal Model of Self-motion
Introduction
Basic Organization of the Peripheral Vestibular System
Framework of The Internal Model
Tilt- and Translation-Selective Neurons in the Cerebellum
Spatiotemporal Tuning
Revealing the Internal Model Computations
Discussion
List of Abbreviations
Mathematical Variables
Chapter 5. Modeling the Generation of Cerebellar Nuclear Spike Output
Introduction
Cerebellar Nucleus Neurons as Simple Inverters
Modeling Rebound Responses
Time-Locking, Synchrony Coding, and the Effect of Irregularity
Conclusions
Chapter 6. Cerebrocerebellar Loops in the Rodent Brain
Introduction
The Corticocerebellar Pathway
Mossy Fibers
Climbing Fibers
Parallel Fibers
Cerebellocerebral Connections
Functional Mapping of the Cerebellocerebral Connections
Conclusion
Chapter 7. Cerebellar Neuronal Codes—Perspectives from Intracellular Analysis In Vivo
Introduction
The Configuration of the Cerebellar Cortical Network
The Flow of Information Through the Cerebellar Neuronal Network
Spike Encoding in the Cerebellar Neurons
Distributed Neuronal Representations
Conclusions
Chapter 8. The Role of the Cerebellum in Optimizing Saccades
The Oculomotor Vermis: The Major Cerebellar Site of Saccades and Saccadic Adaptation
The Caudal Fastigial Nucleus: A Gateway for Saccade-Related Signals Originating from the Oculomotor Vermis
Summary
Chapter 9. Coordination of Reaching Movements: Cerebellar Interactions with Motor Cortex
Anatomical Connectivity Suggests Distinct Roles for the Dentate and Interpositus Nuclei in the Motor System Hierarchy
Deep Cerebellar Nuclei Neurons Have High Spontaneous Firing Rates about Which Movement-Related Modulation Occurs
Relative Timing of Dentate and Interpositus Activity with Respect to Movement Onset
Temporal Correlation with Sensory Cues or Motor Responses
Deep Cerebellar Nuclei Neurons Tend to Show Increased Activity During Movement
The Coding of Movement-Related Parameters in the Deep Cerebellar Nuclei
Does Specific Information about Movement Parameters Get Sent to Motor Cortex from the Deep Cerebellar Nuclei?
Future Directions and Concluding Thoughts
Chapter 10. A Spatiotemporal Hypothesis on the Role of 4- to 25-Hz Field Potential Oscillations in Cerebellar Cortex
Introduction
Synchronization and Oscillations in Cerebellar Circuits
Cerebellar Cortex 4- to 25-Hz Oscillations
Spatiotemporal Aspects of Granule Cell Layer Synchronization
Conditions Supporting A Predictive Sensorimotor Dialog
Granule Cell Layer Oscillations and Internal Models
Conclusion—and Back to the Hockey …
Chapter 11. Single-Neuron and Network Computation in Realistic Models of the Cerebellar Cortex
Introduction
Biophysically Detailed Models of the Cerebellar Neurons and Microcircuits
Large-Scale Spiking Models of the Olivocerebellar Network
Real-Time Models for Closed-Loop Robotic Simulations of Cerebellar Learning and Control
Conclusions
List of Abbreviations
Index
No. of pages: 280
Language: English
Edition: 1
Published: October 7, 2015
Imprint: Academic Press
Paperback ISBN: 9780128013861
eBook ISBN: 9780128016756
DH
Detlef Heck
Associate Professor for UTHSC’s Dept. of Anatomy and Neurobiology, as well as a Visiting Scientist at The Salk Institute for Biological Studies and the Howard Hughes Medical Institute. Dr. Heck's primary research foci are the neuronal foundations of motor/cognitive brain functions and their disorders and the role of coordinated dynamic brain activity in normal and pathological brain function. He serves as Associate Editor for Frontiers in Systems Neuroscience, Review Editor for Frontiers in Neurogenomics, and Editorial Board member for Neuroscience. He was Organizer/Chair for the 2013 SFN symposium on Neuronal Codes and has authored numerous journal articles and book chapters on topics directly related to the proposed.
Affiliations and expertise
Associate Professor, Dept. of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA
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