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Exchangers
1st Edition, Volume 73 - April 15, 2014
Editor: Mark Bevensee
Language: English
Hardback ISBN:9780128002230
9 7 8 - 0 - 1 2 - 8 0 0 2 2 3 - 0
eBook ISBN:9780128002919
9 7 8 - 0 - 1 2 - 8 0 0 2 9 1 - 9
Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist th…Read more
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Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in understanding the current state and future prospects of a particular field.
This volume on exchangers, in conjunction with a previous volume on cotransporters (volume 70), represents an up-to-date, systematic, and comprehensive review of all the major secondary active carrier proteins responsible for the absorption, secretion, and general transport of ions and solutes in mammalian organ systems and additional species. Each chapter is devoted to a specific transporter or a grouping of related transporters based on the well-recognized nomenclature of the SoLute Carrier (SLC) gene family. This book provides readers with the latest mechanistic information on the function and structure of specific transporters, as well as their history and physiological significance.
Comprehensive review of all the major exchangers
Emphasis on protein mechanism with the most recent findings from functional and structural work
Authoritative work from experts in the field
Scientists and researchers in biochemistry and molecular and cellular biology
Dedication
Preface
Contents of Previous Volumes
Chapter One: Structure, Function, and Trafficking of SLC4 and SLC26 Anion Transporters
Abstract
1 Introduction
2 Anion Exchanger 1 Structure and Function
3 AE1 Biosynthesis and N-glycosylation
4 Erythroid AE1 Protein Interactions
5 Erythroid AE1-Associated Diseases
6 Retention and Rescue of AE1 Mutants
7 Kidney AE1 Biogenesis, Interactors, and Associated Pathologies
8 SLC4 Family of Anion Transporters
9 The SLC26 (SulP) Family of Anion Transporters
10 Conclusions and Future Prospects
Chapter Two: Structural Dynamics and Regulation of the Mammalian SLC9A Family of Na+/H+ Exchangers
Abstract
Acknowledgments
1 Introduction
2 Basic Functional Properties: Substrates, Driving Forces and Kinetics of SLC9As
3 Structural Organization and Dynamics of the TM Region of SLC9As
4 SLC9As Exist as Asymmetrical Homodimers in the Membrane
5 The SLC9A C-Terminal Tail: Structure/Disorder, Interaction Partners, and Phosphorylation