Vitamins and Hormones, 1st Edition

Vitamins and Hormones, 1st Edition,Gerald Litwack,ISBN9780080458045

G Litwack   

Academic Press



The study of both vitamins and hormones is essential to our understanding of physiology.

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Key Features

* First published in 1943, Vitamins and Hormones is AP's longest running serial
* Each volume contains cutting edge reviews by leading contributors


First published in 1943, VITAMINS AND HORMONES is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, VITAMINS AND HORMONES continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.


Researchers, professors, and graduate students studying the molecular and cellular biology of vitamins, hormones, and related factors and co-factors

Gerald Litwack

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton, Pennsylvania, as Founding Chair of Basic Sciences and Acting Associate Dean for Research to start a new medical school, The Commonwealth Medical College. Having completing his mission in 2010, he moved to The Institute for Regenerative Medicine, Texas A & M Health Science Center, as Professor of Biochemistry and Associate Director. Currently, he is retired and lives in North Hollywood, California, where he continues as an author and as Series Editor of Vitamins and Hormones. He is involved in writing another textbook and has written a first novel, “One-Eighty”.

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA

View additional works by Gerald Litwack

Vitamins and Hormones, 1st Edition

  • Former Editors
    • Publisher Summary
  • Contributors
    • Publisher Summary
  • Preface
    • Publisher Summary
  • 1: Extrapituitary Effects of the Growth Hormone-Releasing Hormone
    • Abstract
    • I Introduction
    • II Endocrine Role of GHRH in Carcinogenesis
    • III Various Cancers and Normal Tissues That Produce and Respond to GHRH
    • IV Direct Effects of GHRH in Carcinogenesis
    • V Mechanism of Action for Locally Produced GHRH
    • VI Conclusions and Perspectives
    • Acknowledgements
  • 2: IRS-1 and Vascular Complications in Diabetes Mellitus
    • Abstract
    • I Introduction
    • II Insulin Receptor Superfamily
    • III Insulin Receptor Substrates
    • IV Signaling Pathways Regulated by IRS-1
    • V IRS-1 and Insulin Resistance
    • VI The Role of IRS-1 in Atherothrombotic Complications
    • VII Summary and Future Perspectives
    • Acknowledgements
    • Appendix List of Abbreviations
  • 3: Structural and Functional Properties of CCN Proteins
    • Abstract
    • I Discovery of the CCN Gene Family
    • II CCN Family Modular Structure
    • III CCN Family and Heparin Interactions
    • IV CCN Gene Family and Integrins
    • V CCN2 Binding to LRP
    • VI CCN Gene Family and Intracellular Signaling
    • VII The Link Between TGF-β and CCN2
    • VIII CCN Gene Family Action in Normal Biological Processes
    • IX CCN Protein Action in Pathological Disease Processes
    • X Summary
    • Acknowledgements
  • 4: Stanniocalcin: No Longer Just a Fish Tale
    • Abstract
    • I General Introduction
    • II Early Studies on the Discovery and Function of Stanniocalcin in Fish
    • III The Discovery of Mammalian Stanniocalcin
    • IV The Sequestering Hypothesis
    • V Future Directions
    • Acknowledgements
  • 5: Thyroid Hormone Transporters
    • Abstract
    • I Introduction
    • II Thyroid Hormone Transporters
    • III Conclusions
  • 6: Phytoestrogens and Colorectal Cancer Prevention
    • Abstract
    • I Introduction
    • II Phytoestrogens
    • III Experimental Studies
    • IV Concluding Remarks
    • Acknowledgements
  • 7: Transcriptional Activities of Retinoic Acid Receptors
    • Abstract
    • I Introduction
    • II Retinoid Physiology
    • III Retinoid-Binding Proteins
    • IV Transcriptional Regulation by Retinoic Acid Receptors: The Transactivation Process
    • V Transcriptional Regulation by Retinoic Acid Receptors: The Transrepression Process
    • VI Nongenomic Effects of Retinoids
    • VII Conclusion
  • 8: Biochemical and Ionic Signaling Mechanisms for ACTH-Stimulated Cortisol Production
    • Abstract
    • I Introduction
    • II ACTH Receptors: cAMP- and Ca2+-Dependent Signaling
    • III Ionic Mechanisms in ACTH-Stimulated Cortisol Secretion
    • IV Chronic Control of Ion Channel Expression by ACTH in AZF Cells
    • V Summary and Prospects
  • 9: ATP-Dependent Chromatin Remodeling Complexes and Their Role in Nuclear Receptor-Dependent Transcription In Vivo
    • Abstract
    • I Introduction
    • II ATP-Dependent Chromatin Remodeling Complexes
    • III ATP-Dependent Chromatin Remodeling Complexes and Their Role in Nuclear Receptor-Mediated Transcription
    • IV Conclusions
  • 10: Novel Roles for Acylation Stimulating Protein/C3adesArg: A Review of Recent In Vitro and In Vivo Evidence
    • Abstract
    • I Introduction
    • II ASP Production
    • III ASP Function and Role in Metabolism
    • IV ASP Effects on Insulin, Cytokine, and Pituitary Hormone Secretion
    • V Discussion
    • Acknowledgements
    • Appendix Abbreviations
  • 11: STAT3 and Transactivation of Steroid Hormone Receptors
    • Publisher Summary
    • I Introduction
    • II STAT Structure
    • III Mechanisms of STAT Activation and Regulation
    • IV The JAK/STAT Pathway In Nonmammalian Systems
    • V STATs in Human Malignancy
    • VI STAT3 and Steroid Hormone Receptor Activation
    • VII Conclusion
  • 12: Coactivators in Gene Regulation by STAT5
    • Abstract
    • I Signal Transduction by STAT5
    • II Physiological Role of STAT5
    • III Structure and DNA-Binding of STAT5
    • IV Transcriptional Activation by STAT5
    • V Interaction of STAT5 with Other Signaling Pathways
    • VI Regulation of STAT5 Transcriptional Activity by Secondary Modifications
    • VII Conclusions
  • 13: New Insights into the Regulation of Mammalian Sex Determination and Male Sex Differentiation
    • Abstract
    • I Introduction
    • II The Genetics of Male Sex Determination
    • III Hormonal Regulation of Male Sex Differentiation
    • IV Conclusion
  • 14: The Role of Alcohol and Steroid Hormones in Human Aggression
    • Abstract
    • I Introduction
    • II Alcohol
    • III The Endocrinology of Aggression
    • IV The Effect of Alcohol on Steroid Hormones
    • V Conclusions
  • Index
    • Publisher Summary
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