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Sexually Transmitted Diseases
 
 

Sexually Transmitted Diseases, 2nd Edition

Vaccines, Prevention, and Control

 
Sexually Transmitted Diseases, 2nd Edition,Lawrence Stanberry,Susan Rosenthal,ISBN9780123910592
 
 
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Stanberry   &   Rosenthal   

Academic Press

9780123910592

9780124157569

528

229 X 152

Fully updated, Sexually Transmitted Diseases: Vaccines, Prevention and Control, 2e, brings researchers, clinicians and students the most up-to-date findings and thought on physiology and pathogenesis of infection as well as current advances in STD/STI prevention and control methods.

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Key Features

  • Provides comprehensive coverage of epidemiology, physiology and immunology, featuring general preventive strategies such as behavioural modification, barrier methods and topical microbicides
  • Presents individual chapters on Herpes Simplex Virus, Papillomavirus, Hepatitis B, Chlamydia, Gonorrhea, Syphilis, and Bacterial Vaginosis
  • Includes pathogenesis, microbiology and clinical manifestations of each STD, along with current advances in vaccine development

Description

The last decade has seen a huge amount of change in the area of sexually transmitted infection control and prevention, including the development of high-profile vaccines for preventing the spread of cervical cancer-causing human papillomavirus (HPV), novel control methods for HIV and AIDS, and even the discussion of more widespread use of controversial abstinence-only sex education programs. Fully revised and updated to reflect the changes of the past ten years, Sexually Transmitted Diseases: Vaccines, Control and Prevention 2nd Edition brings researchers, clinical investigators, clinicians, and students the most up-to-date research, findings and thought on sexual infection prevention, control and therapy available and serves as an essential reference for anyone working in the field.

Readership

Researchers in virology, microbiology, infectious disease, and immunology; research clinicians and medical microbiologists, vaccine technolgists, molecular biologists, biochemists, and biotechnologists working on vaccine development; centers for disease control, public and world health organizations, pharmaceutical, and biotechnology companies.

Lawrence Stanberry

Dr. Stanberry is a highly respected authority in vaccine development. Dr. Stanberry focuses on sexually transmitted diseases research and has made important contributions in the area of tropical microbicides an in herpes simplex virus pathogenesis, immunobiology, and antiviral therapy. He has played major roles in the pre-clinical and clinical assessment of many of the herpes vaccines currently in development.

Affiliations and Expertise

College of Physicians and Surgeons, Columbia University, New York, USA

Susan Rosenthal

Affiliations and Expertise

Department of Pediatrics, Columbia University Medical Center - College of Physicians and Surgeons New York-Presbyterian Morgan Stanley Children's Hospital, New York City, New York, USA

Sexually Transmitted Diseases, 2nd Edition

Contributors

Foreword

Part I: Epidemiology, Physiology, and Immunology

Chapter 1. Global Epidemiology of Sexually Transmitted Diseases

Introduction

Human Immunodeficiency Viruses

Genital Herpes

Cytomegalovirus

Epstein–Barr Virus

Human Herpesvirus 8 (Hhv8)

Hepatitis B

Hepatitis Delta

Hepatitis C

Hepatitis A

Human PapillomaVirus Infection

Chlamydia

Syphilis

Gonorrhea

The Tropical Sexually Transmitted Diseases

Trichomoniasis

References

Chapter 2. The Genital Tract: Anatomical, Developmental, and Microbiological Factors Affecting Sexually Transmitted Disease Acquisition

Introduction

Anatomy of the Female Genital Tract

Blood Supply to and Lymphatic Drainage of the Female Reproductive Tract

Anatomy of the Male Genital Tract: Genitalia

Genital Tract Infections

References

Chapter 3. Mucosal Immunity in the Human Reproductive Tract: Balancing Reproductive Potential with Protection against Sexually Transmitted Pathogens

Introduction

Biology of the Female Reproductive Tract

Innate Immunity in the Female Reproductive Tract

Adaptive Immunity in the Female Reproductive Tract

Mucosal Immunity to Sexually Transmitted Pathogens

Neisseria gonorrhoeae

Chlamydia trachomatis

Candida albicans

Immunology of the Male Reproductive Tract

Summary

Acknowledgements

References

Part II: Strategies for Prevention and Control

Chapter 4. Contextual Factors Associated with Sexually Transmitted Infections

Introduction

Sexually Transmitted Infection Risk

Prevention and Treatment Strategies

Psychosocial Impact

Conclusions

References

Chapter 5. Abstinence and Curricular Approaches to Sexually Transmitted Infection Prevention for Adolescents

Introduction

Abstinence, Sex, and Adolescent Development

Abstinence as a Strategy to Prevent Sexually Transmitted Infections

Abstinence-Only Sex Education

Comprehensive Sex Education

Support for Abstinence in the Context of Comprehensive Programs

Conclusions

References

Chapter 6. Male Circumcision: A Tool for Prevention of Sexually Transmitted Diseases

Introduction

Prevalence of Male Circumcision

Male Circumcision Reduces Urinary Tract Infections

Male Circumcision Reduces Penile Inflammatory Disorders

Male Circumcision for HIV Prevention Among Heterosexual Men

Male Circumcision for Herpes Simplex Virus Type 2 Prevention

Male Circumcision for HPV Prevention

Male Circumcision and Bacterial Sexually Transmitted Diseases

Male Circumcision for Sexually Transmitted Disease Prevention Among Men Who have Sex with Men

Male Circumcision and HIV Transmission to Female Partners

Male Circumcision and Human Papillomavirus Among Female Partners

Male Circumcision Prevents Bacterial Vaginosis and Trichomoniasis Among Female Partners

The Biological Plausibility of Male Circumcision for Reduction of Viral Sexually Transmitted Diseases

The Risks of Male Circumcision

Cost-Effectiveness and Policy Implications

Conclusions

References

Chapter 7. Issues in Men’s Reproductive Health

Introduction

Epidemiology of Common Sexually Transmitted Infections Among Men

Reproductive Health Issues Among Special Subgroups of Men

Historical Perspective of Men’s Reproductive Healthcare

Barriers and Facilitators of Access to Reproductive Healthcare for Men

Prevention Strategies for Men

Conclusion

References

Chapter 8. Physical Barrier Methods: Acceptance, Use, and Effectiveness

Introduction

The Turbulent Social History of the Male Condom

Manufacture of Male Condoms, Sizes, and International Standards

Condom Breakage and Slippage

Biological MaRkers of Condom Failure

Condoms for Reducing the Risk of Specific Sexually Transmitted Infections

Female Condoms

Diaphragms

Conclusions

References

Chapter 9. Topical Microbicides for Human Immunodeficiency Virus and Sexually Transmitted Disease Prevention

Introduction

Non-Antiretroviral Microbicides

Antiretroviral Microbicides: Tenofovir Gel

Rectal Microbicides

Antiretroviral Microbicides: Rings and Other Formulations

Future Directions – Topical Microbicides in Context

References

Chapter 10. Topical Microbicide Acceptability

What are Microbicides?

What is Acceptability and Why is it Important?

How Does Adherence Differ from Acceptability?

A Review of the Acceptability Literature

Future Directions

Conclusions

References

Chapter 11. STD Vaccine Acceptability in Sexually Transmitted Diseases

Introduction

Acceptability of Sexually Transmitted Infection Vaccines

Acceptance/Uptake of Sexually Transmitted Infection Vaccines

International Perspectives

Strategies for Improving Human Papillomavirus Vaccination Rates in the USA

Risk Compensation

Future Directions

Conclusion

References

Part III: Pathogens and Vaccines

Chapter 12. Genital and Perinatal Herpes Simplex Virus Infections

Disease Manifestations of Genital and Perinatal Herpes

Epidemiology of Genital and Perinatal Herpes

Expected Impact of an Effective Vaccine

Microbiology

Immunology/Immunobiology of Infection

Strategies for Control of Genital and Perinatal HSV Infections

HSV Vaccine Development: An Overview

Future Prospects

References

Chapter 13. The Epidemiology and Control of Human Papillomavirus Infection and Clinical Disease

Introduction

Virology and Pathogenesis of HPV Infection

Epidemiology of HPV Infection

Serological Responses to HPV

Epidemiology of HPV-Associated Disease

Prophylactic Vaccination Against HPV Infection

Summary

References

Chapter 14. Hepatitis B Virus Infection

Introduction

Structure of Hepatitis B Virus

Immune Responses and Serological Diagnosis

Epidemiology

The Carrier State

Diagnosis

Protection Against Hepatitis B

Prevention by Immunization

Non-Response to Hepatitis B Vaccines

Hepatitis B Antibody Escape Mutants

The Immune Response and Some Unresolved Issues

HBV Precore and Other Mutants

Treatment of Hepatitis B

References

Chapter 15. Chlamydia

Clinical Characteristics

Trachoma

Sexually Transmitted Infections

Microbiology

Chlamydial Genomics

Immunobiology

Vaccine Development

Summary and Future Directions

References

Chapter 16. Gonorrhea: Epidemiology, Control, and Prevention

Microbiology of Neisseria Gonorrhoeae

Clinical Disease Caused by Neisseria Gonorrhoeae

Diagnosis and Treatment of Gonorrhea

Epidemiology and Expected Impact of an Effective Vaccine

Vaccine Research and other Strategies for Control

Clinical Studies for Vaccine

References

Chapter 17. Syphilis

Introduction and Historical Background

Epidemiology

Microbiology

Immunology/Immunobiology of Infection

Definitions

Congenital Syphilis

Syphilis and HIV Infection

Diagnosis

Management of Syphilis

Public Health Initiatives

Conclusions

References

Chapter 18. Bacterial Vaginosis

Introduction

Definition

Epidemiology

Other Risks for Bv

Microbiology of Bv

Pathogenesis

Clinical Manifestations

Diagnosis

Treatment

Complications of Bv

Conclusions and Future Directions

References

Color Plates

Index

Quotes and reviews

Praise for the previous edition:

"...presents an abundance of information that provides a clear understanding of sexually transmitted pathogens, factors that must be addressed in efforts to control the spread of disease, and the state of research on barrier methods of prevention and vaccines. ...it will be important reading for students, scientists, and public health practitioners, providing guidance on how best to use the tools we have today while clearly describing the tools needed to complete the armamentarium and the road toward their development."
@source:--David L. Heymann, World Health Organization, in THE NEW ENGLAND JOURNAL OF MEDICINE (April 2001)
@qu:"...the book comprehensively presents the important pathogens of sexually transmitted infections and the research aimed at developing vaccines against them. Past and recent vaccine strategies, current state of vaccine development and their future prospects are discussed in different chapters with great care and sincerity...This book is useful and important reading for those interested in infectious diseases and their prevention, control and vaccine development."
@source:--S. Das in THE JOURNAL OF MEDICAL MICROBIOLOGY (April 2001)
@qu:"very useful and comprehensive information for clinicians, microbiologists and virologists interested in pathogenesis and prevention of STD."
@source:--ACTA VIROLOGICA

 
 
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