Sertoli Cell Biology

Sertoli Cell Biology, 2nd Edition

Sertoli Cell Biology, 2nd Edition,Michael Griswold,ISBN9780124170476

M Griswold   





229 X 152

Update on Sertoli/germ cell research over the past 10 years.

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Key Features

  • Fully revised
  • Written by experts in the field
  • Summarizes 10 years of research
  • Contains clear explanations and summaries  
  • Provides a summary of references over the last 10 years


Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro.


Research scientists in the field of reproductive biology, urologists, andrologists, and endocrinologists

Michael Griswold

Excerpt from Hartman Award from Society for the Study of Reproduction Carl G. Hartman Award (Supported by a grant from Cook Medical) This award is the most prestigious award conferred by the Society for the Study of Reproduction. Each year, this award recognizes an exemplary research career in reproductive biology. The 2013 recipient of the Carl G. Hartman Award is Michael D. Griswold, Ph.D. Dr. Michael D. Griswold, Regents Professor of Molecular Biosciences at Washington State University (WSU), is world-renowned for his contributions to our understanding of Sertoli cell structure and functions and the crucial role of Vitamin A in spermatogenesis and a loyal member of SSR. Mike received a B.S. in Chemistry and Ph.D. in Biochemistry from the University of Wyoming. He conducted postdoctoral studies with Dr. Philip Cohen at the University of Wisconsin, funded by an NIH Postdoctoral Fellowship, working on amphibian metampophosis, and with Dr. Flauco P. Tocchini-Valentini in Rome, funded by an EMBO Fellowship, on Xenopus RNA. Mike spent a year as an Assistant Professor of Pharmacology at Baylor College of Medicine in Houston. He then spent two years as a Research Associate in the laboratory of Dr. Irving Fritz at the University of Toronto, where he acquired what would become a life-long interest in Sertoli cells. Mike joined the faculty of WSU in 1976 as an Assistant Professor of Biochemistry and Basic Medical Sciences, was promoted to Associate and then full Professor, appointed Chair of the Department of Biochemistry and Biophysics in 1994, Director of the School of Molecular Biosciences in 1999, and Dean of the College of Sciences, a position he held from 2003-2010. Mike became a Regents Professor of Molecular Biosciences in 2008, and in 2011, received the WSU Eminent Faculty Award, the highest faculty honor at WSU. Mike’s research has been continuously funded by the NIH since 1977 (with the same grant “Hormonal Control of the Maturation of Sertoli Cells”), including a Research Career Develop Award (1979-1984) and MERIT Award (1997-2007). He has published more than 230 original scientific articles, book chapters, and review articles. His recognition in the field of Sertoli cell function and spermatogenesis is evidenced by his many keynote addresses that include the SSR President’s Symposium (1994 and 2007), Larry Ewing Lecture at Johns Hopkins University (2001), Andrew Nalbandov Lecture at the University of Illinois (1993), Asdell Lecture at Cornell University (2008), the Bailly Lecture at Southern Illinois University (2010), the Serono Lecturer at the Andrology Society (1994), and the Distinguished Faculty Address at WSU (1994). Mike received the WSU Sahlin Excellence in Research Award (1999) and the SSR Research Award (2006), and became an AAAS Fellow in 2009. Mike is an exemplary mentor. He trained 7 MS students, 24 graduate students that include Mike Skinner, Ken Roberts and Leslie Heckert, and 26 postdoctoral fellows and research associates that include Carlos Morales, Kwan Hee Kim, Carol Linder, Dereck McLean, and Cathryn Hogarth. Mike received the Frontiers in Reproduction Beacon Award in 2008 for his outstanding mentoring. One of his former students, Leslie Heckert wrote: “His high expectations returned dedication, creativity and independence from the members of his laboratory, which in turn produced a vibrant and exciting research environment. He led by example, support and occasionally by providing unsolicited words of encouragement...”. Mike has unselfishly served his profession, SSR, the Andrology Society, and the Testis Workshop. He was a member of the SSR Board of Directors (1989-1992), SSR Annual Meeting Program Chair (1998), SSR President-Elect and President (1997-1999), Andrology Society Board of Directors (2000-2003), and Program Committee Chair for Testis Workshop (1993 and 2007) and Andrology Soc

Affiliations and Expertise

School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, U.S.A.

Sertoli Cell Biology, 2nd Edition

Sertoli cell anatomy and cytoskeleton
Fetal Sertoli cells
Early postnatal interactions between Sertoli and germ cells
Stem cell Niche
Role of DMRT1
Hormonal regulation of spermatogenesis through Sertoli cells- Testosterone
Activins and inhibins
Initiation of spermatogenesis and the cycle of the seminiferous epithelium
Retinoic acid metabolism and the cycle of the seminiferous epithelium
Sertoli cell specific transcription and the Sertoli cell cycle
Micro-RNA and spermatogenesis
Large noncoding RNAs (lncRNAs) and lncRNA-mediated epigenetic regulation
Biochemistry of Sertoli-Germ cell junctions, spermiation and movement of germ cells across the barrier
Immunology of the Testis
Diversity and similarities in Sertoli cells from different species
Human Sertoli cells and the SCO syndrome
Gene Knockouts that affect Sertoli cell function

Quotes and reviews

"...a must-have reference for anyone interested in testis development and function. It is one of a kind, offering important and valuable information about the biology of Sertoli cells. Score: 100 - 5 Stars"--Doody's, Sertoli Cell Biology, 2nd Edition
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