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Sertoli Cell Biology
 
 

Sertoli Cell Biology, 2nd Edition

 
Sertoli Cell Biology, 2nd Edition,Michael Griswold,ISBN9780124170476
 
 
 

M Griswold   

Elsevier

9780124170476

9780124170483

488

229 X 152

Update on Sertoli/germ cell research over the past 10 years.

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Key Features

  • Fully revised
  • Written by experts in the field
  • Summarizes 10 years of research
  • Contains clear explanations and summaries  
  • Provides a summary of references over the last 10 years

Description

Sertoli Cell Biology, Second Edition summarizes the progress since the last edition and emphasizes the new information available on Sertoli/germ cell interactions. This information is especially timely since the progress in the past few years has been exceptional and it relates to control of sperm production in vivo and in vitro.

Readership

Research scientists in the field of reproductive biology, urologists, andrologists, and endocrinologists

Michael Griswold

Excerpt from Hartman Award from Society for the Study of Reproduction Carl G. Hartman Award (Supported by a grant from Cook Medical) This award is the most prestigious award conferred by the Society for the Study of Reproduction. Each year, this award recognizes an exemplary research career in reproductive biology. The 2013 recipient of the Carl G. Hartman Award is Michael D. Griswold, Ph.D. Dr. Michael D. Griswold, Regents Professor of Molecular Biosciences at Washington State University (WSU), is world-renowned for his contributions to our understanding of Sertoli cell structure and functions and the crucial role of Vitamin A in spermatogenesis and a loyal member of SSR. Mike received a B.S. in Chemistry and Ph.D. in Biochemistry from the University of Wyoming. He conducted postdoctoral studies with Dr. Philip Cohen at the University of Wisconsin, funded by an NIH Postdoctoral Fellowship, working on amphibian metampophosis, and with Dr. Flauco P. Tocchini-Valentini in Rome, funded by an EMBO Fellowship, on Xenopus RNA. Mike spent a year as an Assistant Professor of Pharmacology at Baylor College of Medicine in Houston. He then spent two years as a Research Associate in the laboratory of Dr. Irving Fritz at the University of Toronto, where he acquired what would become a life-long interest in Sertoli cells. Mike joined the faculty of WSU in 1976 as an Assistant Professor of Biochemistry and Basic Medical Sciences, was promoted to Associate and then full Professor, appointed Chair of the Department of Biochemistry and Biophysics in 1994, Director of the School of Molecular Biosciences in 1999, and Dean of the College of Sciences, a position he held from 2003-2010. Mike became a Regents Professor of Molecular Biosciences in 2008, and in 2011, received the WSU Eminent Faculty Award, the highest faculty honor at WSU. Mike’s research has been continuously funded by the NIH since 1977 (with the same grant “Hormonal Control of the Maturation of Sertoli Cells”), including a Research Career Develop Award (1979-1984) and MERIT Award (1997-2007). He has published more than 230 original scientific articles, book chapters, and review articles. His recognition in the field of Sertoli cell function and spermatogenesis is evidenced by his many keynote addresses that include the SSR President’s Symposium (1994 and 2007), Larry Ewing Lecture at Johns Hopkins University (2001), Andrew Nalbandov Lecture at the University of Illinois (1993), Asdell Lecture at Cornell University (2008), the Bailly Lecture at Southern Illinois University (2010), the Serono Lecturer at the Andrology Society (1994), and the Distinguished Faculty Address at WSU (1994). Mike received the WSU Sahlin Excellence in Research Award (1999) and the SSR Research Award (2006), and became an AAAS Fellow in 2009. Mike is an exemplary mentor. He trained 7 MS students, 24 graduate students that include Mike Skinner, Ken Roberts and Leslie Heckert, and 26 postdoctoral fellows and research associates that include Carlos Morales, Kwan Hee Kim, Carol Linder, Dereck McLean, and Cathryn Hogarth. Mike received the Frontiers in Reproduction Beacon Award in 2008 for his outstanding mentoring. One of his former students, Leslie Heckert wrote: “His high expectations returned dedication, creativity and independence from the members of his laboratory, which in turn produced a vibrant and exciting research environment. He led by example, support and occasionally by providing unsolicited words of encouragement...”. Mike has unselfishly served his profession, SSR, the Andrology Society, and the Testis Workshop. He was a member of the SSR Board of Directors (1989-1992), SSR Annual Meeting Program Chair (1998), SSR President-Elect and President (1997-1999), Andrology Society Board of Directors (2000-2003), and Program Committee Chair for Testis Workshop (1993 and 2007) and Andrology Soc

Affiliations and Expertise

School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA, U.S.A.

Sertoli Cell Biology, 2nd Edition

  • List of contributors
  • Preface
    • References
  • 1. Sertoli cell anatomy and cytoskeleton
    • I Introduction
    • II Sertoli cell morphology
    • III Sertoli cell cytoskeleton
    • IV Concluding remarks
    • References
  • 2. Establishment of fetal Sertoli cells and their role in testis morphogenesis
    • I Introduction
    • II Establishment of the gonadal primordium
    • III Sertoli cell specification and diversion of molecular development toward the testis pathway
    • IV Organizational functions of fetal Sertoli cells
    • Summary
    • References
  • 3. Early postnatal interactions between Sertoli and germ cells
    • I Introduction
    • II Neonatal testis development
    • III Role of Sertoli cells in gonocyte proliferation and migration
    • IV Role of Sertoli cells in formation of primary undifferentiated and differentiating spermatogonial populations
    • V Concluding remarks
    • References
  • 4. The spermatogonial stem cell niche in mammals
    • I Research advances related to the mammalian SSC niche since 2003
    • II Principles of stem cell niches in mammalian tissues
    • III Spermatogonial stem cells
    • IV Location of the SSC
    • V Factors governing SSC self-renewal and differentiation
    • VI The environment inside and outside the niche
    • VII The role of cell migration in SSC self-renewal and differentiation
    • VIII Spermatogonial differentiation
    • IX Niche localization: what controls the controller?
    • X The SSC niche and the cycle of the seminiferous epithelium
    • XI The SSC niche during cell loss
    • XII Perspectives
    • Acknowledgments
    • References
  • 5. DMRT1 and the road to masculinity
    • I Introduction
    • II DMRT1 expression
    • III Regulation of DMRT1
    • IV DMRT1 locus and gene expression
    • V DMRT1 function
    • VI Conclusions
    • References
  • 6. Hormonal regulation of spermatogenesis through Sertoli cells by androgens and estrogens
    • I Introduction
    • II Androgen signaling
    • III Testosterone production and action
    • IV Androgen receptor
    • V The role of androgens in Sertoli cells
    • VI AR-dependent gene expression in Sertoli cells
    • VII Sertoli cell estrogen signaling (from androgens via aromatase)
    • VIII Conclusions and future perspectives
    • References
  • 7. Activins and inhibins in Sertoli cell biology: Implications for testis development and function
    • I Introduction: activin and inhibin link multiple cell types to determine male reproductive health
    • II General structure and signaling pathways
    • III Regulation of inhibin and activin production
    • IV Activin and inhibin function in the adult testis
    • V Activin and inhibin in the developing testis
    • VI The contribution of Smads to regulation of testis development and growth
    • VII Clinical relevance of activin and inhibin for male reproduction
    • VIII Concluding remarks: the need to understand signaling crosstalk in the testis
    • Acknowledgments
    • References
  • 8. The initiation of spermatogenesis and the cycle of the seminiferous epithelium
    • I Introduction and highlights since the last volume
    • II Differentiation of spermatogonia
    • III Evidence that RA is required for the initiation of meiosis
    • IV The initiation of asynchronous spermatogenesis by RA
    • V Regulation of RA synthesis and degradation in the developing testis
    • VI Extrinsic versus intrinsic factors
    • References
  • 9. Retinoic acid metabolism, signaling, and function in the adult testis
    • I Introduction
    • II RA synthesis, signaling, and degradation
    • III Components of the RA pathway within the adult testis
    • IV Maintenance of the spermatogenic cycle by RA
    • V Sertoli cell contributions to RA function within the adult testis
    • VI The effects of retinoids on Sertoli cell function
    • VII Conclusions and remaining questions
    • References
  • 10. Stage-specific gene expression by Sertoli cells
    • I Introduction
    • II Evidence that spermatogenic cells regulate biologically important, stage-specific functions of Sertoli cells
    • III CTSL, a model for the analysis of the function and regulation of stage-specific gene expression
    • IV Stage-specific gene expression as a fundamental characteristic of Sertoli cells
    • V Future directions
    • Acknowledgments
    • References
  • 11. MicroRNAs and Sertoli cells
    • I Noncoding RNAs
    • II miRNAs
    • III The role of miRNAs in spermatogenesis in vivo
    • IV SC-expressed miRNAs and their functions
    • V Regulation of SC-expressed miRNAs
    • VI Perspective
    • References
  • 12. Biochemistry of Sertoli cell/germ cell junctions, germ cell transport, and spermiation in the seminiferous epithelium
    • I Introduction
    • II Cell junctions and their restructuring during the epithelial cycle in the testis
    • III Ectoplasmic specialization
    • IV Spermatid transport and spermiation
    • V Transport of preleptotene spermatocytes at the BTB
    • VI Concluding remarks and future perspectives
    • Acknowledgments
    • References
  • 13. Sertoli cell structure and function in anamniote vertebrates
    • I Introduction
    • II Sertoli cell proliferation
    • III Sertoli cell functions
    • IV Concluding remarks
    • References
  • 14. Adult Sertoli cell differentiation status in humans
    • I Introduction and scope of the chapter
    • II Development of the adult Sertoli cell population
    • III Proliferation and differentiation around puberty
    • IV Differentiation in adult life
    • V Human Sertoli cell differentiation and pathology
    • VI Future perspectives
    • References
  • 15. Gene knockouts that affect Sertoli cell function
    • I Introduction
    • II Genes identified as essential for normal Sertoli cell development and function through KO studies
    • III Lessons learned from the gene KO studies
    • IV Approaches to gene ablation in Sertoli cells
    • V Conclusions and perspectives
    • Acknowledgments
    • References

Quotes and reviews

"While many articles have appeared in journals on the Sertoli cell, this book provides you a rare treat – an extensive and intensive study on it." --Biz India

"...a must-have reference for anyone interested in testis development and function. It is one of a kind, offering important and valuable information about the biology of Sertoli cells. Score: 100 - 5 Stars" --Doody's

 
 
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