• Written in an elegant style by long-time practicing immunologist
• Discusses the changing theories and technologies that guided the field
• Tells of the exciting disputes among prominent scientists
• Lists all the important discoveries and books in the field
• Explains in detail the many Nobel prize-winning contributions of immunologists
Written by an immunologist, this book traces the concept of immunity from ancient times up to the present day, examining how changing concepts and technologies have affected the course of the science. It shows how the personalities of scientists and even political and social factors influenced both theory and practice in the field. With fascinating stories of scientific disputes and shifting scientific trends, each chapter examines an important facet of this discipline that has been so central to the development of modern biomedicine. With its biographical dictionary of important scientists and its lists of significant discoveries and books, this volume will provide the most complete historical reference in the field.
Immunologists, molecular biologists, hematologists, historians of medicine and of science, individuals working in infectious disease
A History of Immunology, 2nd Edition
List of Photos
Foreword: On History and Historians
Preface to the Second Edition
Preface to the First Edition
PART ONE: INTELLECTUAL HISTORY
1. Theories of Acquired Immunity
2. Cellular vs. Humoral Immunity
3. Theories of Antibody Formation
4. The Generation of Diversity: The Germline/Somatic Mutation Debate
5. The Clonal Selection Theory Challenged: The Immunological Self
6. The Concept of Immunologic Specificity
7. Specificity Continued
8. Horror Autotoxicus: The Concept of Autoimmunity
9. Allergy and Immunopathology: The "Price" of Immunity
10. Anti-Antibodies and Anti-Idiotypic Immunoregulation: 1899-1904
11. Transplantation and Immunogenetics
PART TWO: SOCIAL HISTORY
12. Magic Bullets and Poisoned Arrows: The Uses of Antibodies
13. The Royal Experiment: 1721-22
14. The Languages of Immunologic Dispute
15. The Search for Cell-Bound Antibodies. On the Influence of Dogma
16. Natural' Antibodies and 'Virgin' Lymphocytes: The Importance of Context
17. The Dynamics of Conceptual Change in Immunology
18. Immunology in Transition 1951-1972: The Role of International Meetings and Discipline Leaders
19. The Origin of Subdisciplines: (Ocular Immunology; Pediatric Immunology; Immunophysiology)
20. Immune Hemolysis: On the Heuristic Value of an Experimental System
21. Darwinism and Immunology: from Metchnikoff to Burnet
22. The End of Immunology?
Appendix A1. The Calendar of Immunologic Progress
Appendix A2. Seminal Discoveries
Appendix A3. Important Books in Immunology, 1892 – 1968
Appendix B. Nobel Prize Highlights in Immunology
Appendix C. Biographical Dictionary
Quotes and reviews
"Energetic and overwhelmingly successful... The book is presented in a consistent and captivating style which will surely find its reward in a wide readership consisting of students and professionals engaged in diverse disciplines."
"This is as delightful book."
"This work can be recommended with great enthusiasm. Its targeted audience is everyone."
"This History of Immunology is highly recommended to all immunologists; it also can be put to excellent use as an uncommonly lucid introductory Immunology text for medical students and graduate students in immunology."
--Carel J. Van Oss in IMMUNOLOGICAL INVESTIGATIONS
"[A] fascinating history. I recommend this volume highly to any physician or scientist with more than a casual interest in immunology and in the way our modern principles and applications evolved. It is described on the book jacket as a professional, intellectual history. I would go further to say that it is well crafted, and well written -- a pleasure to read."
--JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
"He has written this book with young research workers in mind, to inform them of all the research that has gone into the study of immunology since the introduction of inoculation as a prophylactic measure in the first decades of the 18th century. The book is particularly strong on the controversies that raged over the respective merits of cellular and humoral immunity."
--JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
"Arthur Silverstein's A History of Immunology is sure to be the standard in the field upon which future efforts will be based... A comprehensive overview of the development of the major concepts of the discipline that is both descriptive and analytical... It is a fine piece of scholarship for all to enjoy and will undoubtedly form an indispensable starting point for future scholars who wish to examine the development of knowledge about the phenomenon of the immune response."
--Dexter Howard in ACADEMIC MEDICINE
"He has written each chapter to be self-sufficient and truly succeeds in this attempt... The appendices are invaluable... This book provides a broad background of the discipline of immunology which the reader can easily supplement with recent textbooks."
--OHIO JOURNAL OF SCIENCE
"Silverstein managed to write a scientific book that is interesting, entertaining, and educating alike."
--EXPERIMENTAL AND CLINICAL IMMUNOGENETICS