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The Autoimmune Diseases
 
 

The Autoimmune Diseases, 4th Edition

 
The Autoimmune Diseases, 4th Edition,Ian Mackay,Noel R Rose,ISBN9780125959612
 
 
 

Mackay   &   Rose   

Academic Press

9780125959612 New edition

9780080454740

1160

279 X 216

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Key Features

New to This Edition:
* Tissue-specific interventions to arrest or "cure" autoimmune disease
* Bone marrow eradication and replacement
* Both basic science and clinical medicine is covered
* Boxed points to emphasize key features of each chapter

Description

Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.

Readership

Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases

Ian Mackay

Affiliations and Expertise

Monash University, Clayton, Victoria, Australia

View additional works by Ian R. Mackay

Noel R Rose

Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.

Affiliations and Expertise

Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA

View additional works by Noel R Rose

The Autoimmune Diseases, 4th Edition

IMMUNOLOGIC BASIS OF AUTOIMMUNITY
AUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITION
STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITY
GENERAL FEATURES OF THE AUTOIMMUNE DISEASES
ANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITY
MHC COMPLEX AND AUTOIMMUNITY
T CELLS AND AUTOIMMUNITY
ROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITY
TOLERANCE AND AUTOIMMUNITY – T CELLS
REGULATORY T CELLS
PEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLS
B CELLS AND AUTOIMMUNITY
MEMORY B CELL DEVELOPMENT
TOLERANCE AND AUTOIMMUNITY – B CELLS
GENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITION
APOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENS
EFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXES
FUNCTIONAL EFFECTS OF ANTIBODIES
ADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES
SIGNALING PATHWAYS IN T AND B LYMPHOCYTES
GENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASES
GENETICS AND AUTOIMMUNITY - NON-MHC
INFECTIONS, IMMUNITY AND AUTOIMMUNITY
NON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITY
VACCINES AND AUTOIMMUNE DISEASES
SEX, PREGNANCY AND AUTOIMMUNITY

MULTISYSTEM DISEASES
ANIMAL MODELS FOR AUTOIMMUNE DISEASE
SYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS,
AND MIXED CONNECTIVE TISSUE DISEASE
THE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS
SYSTEMIC SCLEROSIS- SCLERODERMA
ANTIPHOSPHOLIPID SYNDROME
SJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS)
RHEUM ATOID ARTHRITIS
SPONDYLOARTHRITIS AND CHRONIC IDIOPATHIC ARTHROPATHIES
POLYMYOSITIS AND DERMATOMYOSITIS*

ENDOCRINE AND RELATED DISEASES
THYROID DISEASE
TYPE 1 DIABETES
ADRENALITIS
POLYENDOCRINE SYNDROMES
AUTOIMMUNE GASTRITIS AND PERNICIOUS ANEMIA
AUTOIMMUNE HYPOPHYSITIS

BLOOD DISEASES
AUTOIMMUNE HEMOLYTIC ANEMIA
AUTOIMMUNE THROMBOCYTOPENIC PURPURA
AUTOIMMUNE NEUTROPENIA
ACQUIRED APLASTIC ANEMIA
CLOTTING DISORDERS

NEUROLOGIC DISEASES
MULTIPLE SCLEROSIS
PERIPHERAL NEUROPATHIES
MYASTHENIA GRAVIS AND ANTI-RECEPTOR DISEASES OF THE NERVOUS SYSTEM
UVEITIS
INNER EAR DISEASE

INTESTINAL, HEPATIC, AND PANCREATIC DISEASES
CELIAC DISEASE
INFLAMMATORY BOWEL DISEASES: ULCERATIVE COLITIS AND CROHN’S DISEASE
CHRONIC HEPATITIS
PRIMARY BILIARY CIRRHOSIS
PRIMARY SCLEROSING CHOLANGITIS
AUTOIMMUNE PANCREATITIS

CUTANEOUS DISEASES
BULLOUS SKIN DISEASES: PEMPHIGUS VULGARIS AND OTHER TYPES OF PEMPHIGUS
NON-BULLOUS SKIN DISEASES: ALOPECIA, PSORIASIS, VITILIGO, URTICARIA

UROGENITAL DISEASES
KIDNEY: GOODPASTURE’S DISEASE, LUPUS NEPHRITIS, ANCA-ASSOCIATED GLOMERULONEPHRITIS
AUTOIMMUNE ORCHITIS AND MALE INFERTILITY
OOPHORITIS

CARDIOVASCULAR AND PULMONARY DISEASES
RHEUMATIC HEART DISEASE
MYOCARDITIS AND DILATED CARDIOMYOPATHY
ATHEROSCLEROSIS: AUTOIMMUNITY TO HEAT-SHOCK PROTEINS
NECROTIZING ARTERITIS AND SMALL VESSEL VASCULITIS
VASCULITIS
IDIOPATHIC BRONCHIOLITIS OBLITERANS, IDIOPATHIC PULMONARY FIBROSIS, AND THE AUTOIMMUNE DISORDERS OF THE LUNG

NEOPLASIA AND AUTOIMMUNITY
PARANEOPLASTIC DISEASES – AUTOIMMUNE RESPONSES TO TUMOR ANTIGENS
LYMPHOMA AND AUTOIMMUNE DISEASE
APOPTOSIS AND AUTOIMMUNITY -
LYMPHOPROLIFERATIVE SYNDROMES

MISCELLANEOUS
CAMEOS

DIAGNOSIS, PREVENTION, AND THERAPY
AUTOANTIBODY ASSAYS, TESTING AND STANDARDIZATION
T-CELL ASSAYS
PREDICTION OF AUTOIMMUNE DISEASE
THE PREVENTION OF AUTOIMMUNE DISEASE: TYPE 1 DIABETES AS A PARADIGM
EMERGING THERAPIES IN AUTOIMMUNE DISEASES
EPILOGUE - ADVOCATUS DIABOLI

Quotes and reviews

"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects...This thoughtfully updated new edition takes into consideration important developments in basic and clinical science...This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition."
- Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE (Jan 2006)
 
 
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